Members of the G protein-coupled receptor family of integral membrane proteins, the LPL Receptor (Lysophospholipid Receptor) group are crucial for lipid signaling. There are eight LPL receptors in humans, and different genes each encode one of them. Other names for these LPL receptor genes include "Edg." In the cell membrane, LPL receptor ligands bind to and activate their corresponding receptors. The activated receptor can have a variety of effects on the cell, depending on the ligand, receptor, and type of cell involved. These include primary effects such as adenylyl cyclase inhibition and calcium release from the endoplasmic reticulum, as well as secondary effects such as cell proliferation and apoptosis prevention. Type: S1PR1, S1PR2, S1PR3, S1PR4, S1PR5, LPAR1, LPAR2, LPAR3, LPAR4, LPAR5, and LPAR6.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V75443 | (S)-FTY720-phosphonate | 1142015-10-8 | FTY720 (S)-Phosphate is an S1P receptor 1 (S1PR1) agonist that may be utilized to study acute inflammation such as acute lung injury. |
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V75439 | 1-Oleoyl lysophosphatidic acid (1-Oleoyl-sn-glycero-3-phosphate; 1-Oleoyl-LPA) | 65528-98-5 | 1-Oleoyl lysophosphatidic acid (1-Oleoyl-sn-glycero-3-phosphate) is an abundant lysophosphatidic acid species with high bioactivity due to its strong affinity for LPA receptors. |
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V75444 | A6770 | 1331754-16-5 | A6770 is an orally bioactive sphingosine-1-phosphate (S1P) lyase (S1PL) inhibitor. |
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V33497 | AM095 free acid | 1228690-36-5 | AM095 free acid is a novel, potent and selective LPA1 receptor antagonist that inhibited GTPγS binding to Chinese hamster ovary (CHO) cell membranes overexpressing recombinant human or mouse LPA1 with IC50 of 0.98 and 0.73 μM, respectively. |
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V7134 | AM095 sodium | 1345614-59-6 | AM095 sodium is a novel, potent and selective LPA1 receptor antagonist that inhibited GTPγS binding to Chinese hamster ovary (CHO) cell membranes overexpressing recombinant human or mouse LPA1 with IC50 of 0.98 and 0.73 μM, respectively. |
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V4697 | Amiselimod HCl | 942398-84-7 | Amiselimod HCl (formerly also known as MT-1303) is a novel, potent and selective immunosuppressant and sphingosine 1 phosphate receptor (S1P1) modulator. |
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V75440 | Amiselimod hydrochloride (MT-1303 hydrochloride) | 942398-84-7 | Amiselimod HCl is a novel modulator of the S1P1 receptor. |
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V3470 | BMS-986020 | 1257213-50-5 | BMS-986020 (also known as AM152 and AP-3152 free acid) is a novel, potent and selective LPA1 (lysophosphatidic acid) antagonist. |
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V17881 | Cenerimod | 1262414-04-9 | Cenerimod (ACT-334441) is a potent and orally bioavailable immunomodulator, which exhibited an EC50 of 2.7 nM. |
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V3771 | Ceralifimod | 891859-12-4 | Ceralifimod (also known asONO-4641) is a novel sphingosine-1-phosphate (S1P) receptor agonist selective for S1P1 and S1P5. |
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V18990 | CYM-50308 | 1345858-76-5 | CYM50308 (ML248) is a potent, selective and high-affinity sphingosine-1-phosphate receptor 4 (S1P4-R) agonist with EC50 of 56 nM. |
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V7018 | CYM-5442 | 1094042-01-9 | CYM-5442 is anovel, potent and highly-selective S1P1 (Spingosine 1-Phosphate Receptor 1) agonist which reduces the severity of acute GVHD by inhibiting macrophage recruitment. |
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V3237 | CYM-5541 (ML249) | 945128-26-7 | CYM-5541 (also known as ML249) is a potent, selective, full, and allosteric agonist of the S1P3(Sphingosine 1-phosphate) receptor with EC50in the range of 72 to 132 nM. |
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V75461 | CYM50358 | 1314212-39-9 | CYM50358 is a potent and specific S1PR4 antagonist (inhibitor) with IC50 of 25 nM. |
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V20842 | Etrasimod | 1206123-37-6 | Etrasimod (formerly APD334; APD3-34) is a potent, centrally bioavailable, functional antagonists of the S1P1 receptor for use as next generation therapeutics for treating multiple sclerosis (MS) and other autoimmune diseases. |
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V2475 | GLPG2938 | 2130996-00-6 | GLPG2938 is a potent and specific S1P2 antagonist. |
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V3553 | GSK2018682 | 1034688-30-6 | GSK2018682 is a novel and potent agonist for S1P1 and S1P5 receptor (sphingosine 1 phosphate receptor) with pEC50s of 7.7 and 7.2, respectively, and it has no agonist activity towards human S1P2, S1P3, or S1P4. S1P4. |
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V75454 | H2L 5765834 | 420841-84-5 | H2L 5765834 is an antagonist of lysophosphatidic acid receptors LPA1, LPA3 and LPA5, with IC50s of 94, 752 and 463 nM respectively. |
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V18417 | YUN88562 | 1514888-56-2 | YUN88562, formerly known as S1p receptor agonist 1, is an S1P receptor agonist found in patent WO 2015039587 A1, compound example 2. |
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V75460 | L-threo Lysosphingomyelin (d18:1) (L-threo-Sphingosylphosphorylcholine) | 105615-55-2 | L-threo Lysosphingomyelin (d18:1) (L-threo-Sphingosylphosphorylcholine) is an endogenous bioactive sphingolipid. |
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