COX

Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD
GPCR & G Protein

5-HT Receptor Adenosine Receptor Adenylate Cyclase Adrenergic Receptor Angiotensin Receptor APJ Bombesin Receptor Bradykinin Receptor cAMP Cannabinoid Receptor CaSR CCK receptor CCR CGRP Receptor CRFR CXCR Dopamine Receptor EBI2 Endothelin Receptor Formyl Peptide Receptor Free Fatty Acid Receptor G protein-coupled Bile Acid Receptor GCGR GHSR GLP Receptor Glucagon Receptor GnRH Receptor GPCR19 GPR GPR109A Guanylate Cyclase Hedgehog(Smoothened) ROCK Histamine Receptor ICMT Leukotriene Receptor LPA Receptor LPL Receptor LTR mAChR Melanocortin Receptor Melatonin Receptor mGluR Motilin Receptor MRGPR MT Receptor Neurokinin Receptor Neuropeptide Y Receptor Neurotensin Receptor NPY receptor Opioid Receptor OX Receptor Oxytocin Receptor P2Y Receptor PAFR PAR PKD PKG Prostaglandin Receptor Ras RGS Protein S1P Receptor SGLT Sigma Receptor Somatostatin Receptor TAAR TSH Receptor Urotensin Receptor Vasopressin Receptor

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COX

The enzyme cyclooxygenase (COX), also referred to as prostaglandin-endoperoxide synthase (PTGS), is in charge of producing the vital biological mediators known as prostanoids, such as prostaglandins, prostacyclin, and thromboxane. Pain and inflammation symptoms can be reduced by pharmacologically inhibiting COX. The general public has had access to cyclooxygenase activity-inhibiting medications for about 100 years, including aspirin. The two cyclooxygenase isoforms, COX-1 and COX-2, have been identified. The COX-1 enzyme is frequently produced constitutively (i.e., in the gastric mucosa), whereas the COX-2 enzyme is induced (i.e., at sites of inflammation). Aspirin and ibuprofen are examples of NSAIDs that work by inhibiting COX to produce their desired effects. The non-steroidal anti-inflammatory drugs (NSAIDs) are the primary COX inhibitors.

COX related products

Cat No.	Product Name	CAS No.	Product Description
V77404	(+/-)-Catechin Gallate-13C3 (Catechin Gallate 13C3)		(+/-)-Catechin Gallate-13C3 is a 13C (carbon 13)-labeled (-)-Catechin gallate.
V77593	2-O-Sinapoyl makisterone A		2-O-Sinapoyl makisterone A (compound 2) is a sinapic acid-ecdysterone hybrid and is a selective inhibitor of COX-2.
V33020	Anemarsaponin B	139051-27-7	Anemarsaponin B is a naturally occuring steroidal saponin extracted from the rhizomes of A.
V78015	Anti-inflammatory agent 52		Anti-inflammatory agent 52 (compound 7j) is an orally bioavailable, potent and specific COX-2 inhibitor.
V78016	Anti-inflammatory agent 53		Anti-inflammatory agent 53 (compound 7c) is an orally bioavailable, potent and specific COX-2 inhibitor.
V2894	ATB-346	1226895-20-0	ATB-346, a structural analog of naproxen (one of the NSAIDs-Nonsteroidal anti-inflammatory drugs), is anti-inflammatory agent.
V31157	Byakangelicol	26091-79-2	Byakangelicol, a leukotriol extracted from Angelica dahurica, inhibits interleukin-1β (IL-1β)-induced prostate cancer in A549 cells by inhibiting the expression and activity of cyclooxygenase-2 (COX-2).
V2102	CAY10404	340267-36-9	CAY10404 is novel, and highly selective inhibitor of COX-2 which has been reported to date, with a selectivity index (SI; SI = IC50COX-1/IC50COX-2) of >500,000.
V31341	Chebulagic acid	23094-71-5	Chebulagic acid is a naturally occurring COX-LOX dual inhibitorisolated from the Terminalia chebula Retz.
V78861	COX-1/2-IN-4		COX-1/2-IN-4 is a COX inhibitor (antagonist) with IC50s of 0.239 μM and 0.191 μM for COX-1 enzyme and COX-2 enzyme, respectively.
V79761	COX-1/2-IN-5		COX-1/2-IN-5 (compound 2a) is a dual (bifunctional) inhibitor of COX1/2 (IC50=2.650 μM, 0.958 μM) with anti-cancer activity.
V80073	COX-2-IN-31		COX-2-IN-31 (compound 7b) is an orally bioactive COX/5-LOX dual (bifunctional) inhibitor (antagonist) with IC50 of 60 nM (COX-2) and 0.9 μM (5-LOX).
V78864	COX-2-IN-33		COX-2-IN-33 (compound 5f) is a COX-2 inhibitor (IC50=45.5 nM) and a potential anti-inflammatory agent.
V79472	COX-2-IN-35		COX-2-IN-35 (compound 7) is a selective COX-2 inhibitor (antagonist) with IC50 of 4.37 nM.
V78603	COX-2/15-LOX-IN-2		COX-2/15-LOX-IN-2 is a potent dual COX-2 and 15-LOX inhibitor (antagonist) with IC50s of 0.065 μM and 1.86 μM, respectively.
V78897	COX-2/15-LOX-IN-3		COX-2/15-LOX-IN-3 (compound 5k) is a dual (bifunctional) inhibitor of COX-2/15-LOX with IC50s of 0.075 μM and 1.97 μM respectively.
V79276	COX-2/15-LOX-IN-4		COX-2/15-LOX-IN-4 (compound 5i) is a dual (bifunctional) inhibitor of COX-2/15-LOX with IC50s of 0.075 μM and 1.97 μM, respectively.
V8259	Deracoxib (SC 046; SC 46; SC 59046)	169590-41-4	Deracoxib (SC-046; SC-46; SC-59046) is a novel and potent NSAID and COX-2 inhibitor used to treat osteoarthritis.
V40446	Desmethyl Celecoxib	170569-87-6	Desmethyl Celecoxib (PTPBS) is an demethylated metabolite of Celecoxib (SC58635; YM-177;SC-58635; YM 177; Celebrex; Xilebao) which is cyclooxygenase-2 (COX-2) inhibitor approved asananti-inflammatory agent of the NSAID class.
V19799	Diclofenac	15307-86-5	Diclofenac (formerly GP-45840; Voltarol; Voltaren) is a potent nonsteroidal anti-inflammatory drug (NSAID), acting as a non-selective COX inhibitor with IC50 of 0.5 μg/ml and 0.5 μg/ml for COX-1 and -2 in intact cells, respectively, used to relieve pain and reduce swelling in flammation.