Monoamine oxidases (MAO) are a family of enzymes that catalyze the oxidation of monoamines.In the majority of the body's cell types, they are discovered bound to the mitochondria's outer membrane. They are a member of the flavin-containing amine oxidoreductase protein family. The oxidative deamination of monoamines is catalyzed by monoamine oxidases. By using oxygen to remove an amine group from a molecule, the resulting aldehyde and ammonia are produced. Flavoproteins are monoamine oxidases because they have the cofactor FAD covalently bound to them. MAO dysfunction is thought to be the cause of a number of psychiatric and neurological disorders due to the critical part MAOs play in the inactivation of neurotransmitters. While MAO-B inhibitors are used alone or in combination to treat Alzheimer's and Parkinson's diseases, MAO-A inhibitors have antidepressant and antianxiety properties.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V4650 | Eprobemide | 87940-60-1 | Eprobemide is a potent non-competitive reversible inhibitor ofmonoamine oxidase A, which was used as an antidepressant in Russia (under the trade name Befol). |
|
V2630 | Isatin (Indoline-2,3-dione) | 91-56-5 | Isatin (also named 2,3-Indolinedione)is an endogenous MAO inhibitor. |
|
V10246 | Pargyline Hydrochloride | 306-07-0 | Pargyline HCl is an irreversible MAO (monoamine oxidase) inhibitor (antagonist) with Ki of 13 μM for MAO-A and 0.5 μM for MAO-B. |
|
V30322 | Phenelzine | 51-71-8 | Phenelzine is a novel and potent monoamine oxidase inhibitor (MAOI), antidepressant agent and anxiolytic agent |
|
V16566 | Toloxatone(MD 69276) | 29218-27-7 | Toloxatone, aslo known as MD 69276, is an antidepressant launched in 1984 in France for the treatment of depression. |
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