HIV protease, a homodimeric aspartyl protease, is essential for the viral life cycle because it breaks down proviral polyproteins to produce mature protein components needed to create an infectious virus. In order to create the mature protein components of an infectious HIV virion, HIV protease cleaves newly synthesized polyproteins at the proper locations. When developing anti-retroviral medications to treat HIV/AIDS (acquired immune deficiency syndrome), HIV protease is a crucial drug target.
HIV-1 protease breaks down the polyproteins Gag and Gag-Pro-Pol to allow viral maturation. More than 12 different substrates are recognized and broken down, which causes viral maturation. Similar to HIV-1, HIV-2 protease is a homodimeric aspartyl enzyme that plays a crucial part in the HIV life cycle by processing the precursor polyproteins Gag and Gag-Pro-Pol, which results in viral maturation.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V73172 | 2α,19α-Dihydroxy-3-oxo-urs-12-en-28-oic acid | 176983-21-4 | 2α,19α-Dihydroxy-3-oxo-urs-12-en-28-oic acid is a natural ursane-type triterpene and an effective HIV protease (HIV Protease) inhibitor. |
|
V73171 | HIV-1 protease-IN-6 | 2892016-32-7 | HIV-1 protease-IN-6 (compound 17d) is a potent HIV-1 protease inhibitor (antagonist) with IC50 of 21 pM and a Ki of 4.7 pM. |
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V73170 | HIV-1 protease-IN-7 | 2916441-36-4 | HIV-1 protease-IN-7 (compound 16) is an orally bioactive HIV-1 protease inhibitor (IC50=3.52 nM, EC50=37 nM). |
|
V33345 | Saquinavir (Ro-31-8959; Invirase; Fortovase) | 127779-20-8 | Saquinavir (Ro-31-8959; Invirase; Fortovase),an HIV Protease Inhibitor,is an antiretroviral drug used together with other medications to treat or prevent HIV/AIDS. |
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