Dihydrofolate reductase (DHFR), which is found in both prokaryotic and eukaryotic cells, catalyzes the conversion of dihydrofolate to tetrahydrofolate using NADPH. In addition to treating bacterial, fungal, and mycobacterial infections, DHFR inhibitors are frequently used to treat malaria and other protozoal infections.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V71989 | 4′-DTMP | 21253-58-7 | 4′-DTMP is a DHFR inhibitor (antagonist) with Ki of 5.1 nM (DHFRWT) and 34.3 nM (DHFRL28R). |
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V5235 | Aminopterin (4-Aminofolic acid) | 54-62-6 | Aminopterin (4-Aminofolic acid; APGA) is a novel and synthetic folic acid derivative used as a rodenticide that has been shown to be teratogenic, but whose metabolite is a competitive inhibitor of dihydrofolate reductase, which is a cofactor for nucleic acid synthesis. |
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V80014 | DHFR-IN-11 | DHFR-IN-11 (compound 6b) is a DHFR inhibitor that can suppress Mycobacterium tuberculosis (TB) DHFR enzyme with IC50 of 5.70 μM. | |
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V78500 | DHFR-IN-12 | DHFR-IN-12 (Compound 5c) is a DHFR inhibitor (antagonist) with good anti-bacterial effect. | |
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V71990 | DHFR-IN-5 | 1142407-81-5 | DHFR-IN-5 is a potent and orally bioactive dihydrofolate reductase (DHFR) inhibitor (antagonist) with a Ki of 0.54 nM against Plasmodium falciparum mutants. |
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V2027 | Leucovorin Calcium | 1492-18-8 | Leucovorin calcium, a reduced folic acid andan active metabolite of folic acid, is a derivative of folic acid which can be used to increase levels of folic acid under conditions favoring folic acid inhibition. |
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V25456 | Leucovorin calcium hydrate | 6035-45-6 | Leucovorin calcium, a reduced folic acid andan active metabolite of folic acid(also known as folinic acid and citrovorum factor), is a derivative of folic acid which can be used to increase levels of folic acid under conditions favoring folic acid inhibition. |
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V0847 | Methotrexate | 59-05-2 | Methotrexate (MTX; alphamethopterin; amethopterin; methylaminopterin;CL-14377;NCIC04671;WR19039; NCI-C04671)is an FDA approvedantineoplastic and immunosuppressant drug that belongs to theantimetabolite and antifolate class of drugs. |
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V0851 | Pemetrexed Disodium Hydrate | 357166-30-4 | Pemetrexed Disodium Hydrate (LY-231514;HSDB-7316; trade name Alimta), the hydrated disodium salt of Pemetrexed which is a synthetic pyrimidine-based antifolate, is a novel antifolate and antimetabolite anticancer drug targeting TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively. |
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V0848 | Pralatrexate (racemic) | 146464-95-1 | Pralatrexate (PDX; trade name Folotyn), an antifolate which is structurally a folate analog, is a potent and selective inhibitor of dihydrofolate reductase (DHFR) exhibiting high affinity for reduced folate carrier-1 (RFC-1) with antineoplastic and immunosuppressive activities. |
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V0849 | Pyrimethamine | 58-14-0 | Pyrimethamine(Malocid;Khloridin;BW 50-63;NCI-C01683; BW50-63; Daraprim; NSC 3061; Tindurin; WR-297;RP-4753) is a potent dihydrofolate reductase (DHFR) inhibitor which isused as an antimalarialandantiprotozoaldrug. |
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V0850 | Sulfameter | 651-06-9 | Sulfameter (Bayrena; Sulfametoxydiazine; 5-Methoxysulfadiazine; NSC-683528;I-2586;SH-613) is a novel,long-acting sulfonamide antibacterial agent used as a leprostatic agent and also is used to treat UTIs/urinary tract infections. |
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