The positive-strand RNA virus known as hepatitis C virus (HCV) belongs to the family Flaviviridae's genus Hepacivirus. At least six genotypes (gt) of HCV exist, and the polymerase's error-prone nature results in more than 50 subtypes. The host and viral proteases break down the long open reading frame, which encodes the HCV polyprotein, into seven nonstructural (NS) proteins (p7, NS2, NS3, NS4A, NS4B, NS5A, and NS5B) and three structural proteins (the capsid protein core and envelope glycoproteins E1 and E2). While NS3 to NS5B are involved in a membrane-associated RNA replicase complex (RC), NS2 and p7 are required for virus assembly but not RNA replication.NS4A acts as a cofactor for the NS3 serine protease, NS5B is the RNA-dependent RNA polymerase, and NS5A is thought to play important roles in numerous stages of the HCV life cycle. The NS3 protein is made up of a serine protease and an RNA helicase/nucleoside triphosphatase (NTPase).After being administered to HCV-infected cells, NS5A inhibitors quickly reduce the virus' ability to infect cells.
By preventing Kv2.1 function and preventing apoptosis, the HCV protein NS5A prevents the loss of intracellular potassium that would otherwise occur in hepatocytes.
Alpha interferon, Telaprevir, the NS5A inhibitor BMS-790052, and PSI-7977, as well as the combination of lucidone and alpha interferon, all work synergistically to inhibit HCV RNA replication.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V54173 | (Tetrahydro-2H-pyran-4-yl)methanol | 14774-37-9 | (Tetrahydro-2H-pyran-4-yl)methanol is a biochemical compound that can be used as a biomaterial or organic/chemical reagent for biomedical research. |
|
V53271 | 2'-C-Methyladenosine | 15397-12-3 | 2'-C-Methyladenosine is an inhibitor (blocker/antagonist) of HCV (hepatitis C virus) replication. |
|
V53157 | 2'-O-Methylcytidine | 2140-72-9 | 2'-O-Methylcytidine is a 2'-generation nucleoside that can inhibit HCV (hepatitis C virus) replication. |
|
V76311 | 6-Chloro-7-deazapurine-2F-β-D-arabinofuranose | 169516-60-3 | 6-Chloro-7-deazapurine-2F-β-D-arabinofuranose is a nucleoside analogue. |
|
V4403 | ABT-072 | 1132936-00-5 | ABT-072 is a novel and potent nonnucleosideNS5B polymeraseinhibitor and a candidate drug evaluated for treatment of hepatitis C virus (HCV). |
|
V52456 | ABT-072 potassium trihydrate | 1132940-31-8 | ABT-072 (potassium trihydrate) is an orally bioactive and potent non-nucleoside HCV (hepatitis C virus) NS5B polymerase inhibitor (HCV (hepatitis C virus) GT1a EC50=1 nM; HCV (hepatitis C virus) GT1b EC50=0.3 nM). |
|
V54241 | Ac-D-DGla-LI-Cha-C | 208940-40-3 | Ac-D-DGla-LI-Cha-C is a potent HCV (hepatitis C virus) protease inhibitor peptide. |
|
V54240 | Ac-EEVVAC-pNA | 389868-12-6 | Ac-EEVVAC-pNA is a chromogenic substrate for the continuous spectrophotometric determination of HCV (hepatitis C virus) NS3 protease. |
|
V54238 | AL-611 | 2481279-61-0 | AL-611 is an HCV (hepatitis C virus) NS5B polymerase inhibitor (EC50 = 5 nM). |
|
V54233 | Antiviral agent 30 | 381731-49-3 | antiviral compound 30 (Example 118) is an antiviral compound. |
|
V76306 | Apigenin-4'-α-L-rhamnoside | 133538-77-9 | Apigenin-4'-α-L-rhamnoside is a potent HBV (hepatitis B virus) inhibitor. |
|
V5119 | Artemisinin (Qinghaosu; NSC 369397) | 63968-64-9 | Artemisinin (also known as qinghaosu in Chinese; NSC-369397), discovered by Tu Youyou (2015 Nobel Prize winner in Medicine) team, is a naturally occurring anti-malarial drug isolated from the aerial parts ofArtemisia annuaL. |
|
V54227 | ASP5286 | 935735-70-9 | ASP5286 is a novel non-immune cyclophilin inhibitor for the study of HCV (hepatitis C virus). |
|
V3153 | Asunaprevir | 630420-16-5 | Asunaprevir (formerly BMS-650032; BMS-650032; trade name in Japan and Russia: Sunvepra) is a potent and orally bioavailable small molecule inhibitor of thehepatitis C virus (HCV) NS3 (non-structural) protease that has been approved for use in Japan as part of a combination treatment for HCV infections. |
|
V2064 | Balapiravir (R1626, Ro 4588161) | 690270-29-2 | Balapiravir (also known as R1626 and Ro 4588161) is the tri-isobutyl ester prodrug of R1479 which is a nucleoside analogue inhibitor of the hepatitis C virus (HCV) RNA-dependent RNA polymerase. |
|
V3517 | Beclabuvir (BMS-791325) | 958002-36-3 | Beclabuvir (formerlyknown as BMS-791325) is a novel, potent and non-nucleoside inhibitor of the HCV NS5B RNA polymerase, with nanomolar activity against HCV genotypes 1, 3, 4, 5 and 6 in vitro. |
|
V52352 | Beclabuvir (BMS-791325) | 958002-33-0 | Beclabuvir is an HCV (hepatitis C virus) NS5B RNA-dependent RNA polymerase inhibitor that can also inhibit the activity of NS5B protein expressed by HCV (hepatitis C virus) genotypes 1, 2, 4, and 5, with IC50s < 28 nM. |
|
V76303 | Besifovir (LB80331) | 441785-25-7 | Besifovir (LB80331) is the parent active molecule of LB80380 and is further metabolized to its active form LB80317. |
|
V54219 | Cepeginterferon alfa-2b | 1192706-52-7 | Cepeginterferon alfa-2b is a pegylated interferon with a PEG base of 20 kDa molecular weight. |
|
V53237 | CpG ODN 10101 (ODN 10101) | 1234402-77-7 | CpG ODN 10101 is a synthetic oligodeoxynucleotide (ODN) that is a Toll-like receptor 9 (TLR9) agonist. |
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
