Phosphatases are enzymes that strip a protein of its phosphate group. PTPs (protein tyrosine phosphatases) are a large family of cytoplasmic and transmembrane enzymes. PTPs are crucial in maintaining the integrity of cell-cell and cell-matrix contacts as well as controlling the proliferative activity of cells. PTP1B, a non-receptor PTP, is frequently found in the endoplasmic reticulum and in vesicles that are close to the plasma membrane.PTP1B has been a popular therapeutic target for the management of type 2 diabetes mellitus and obesity due to its important role as a negative regulator of leptin receptor pathways. Animal cell cytoplasm contains four major serine/threonine-specific protein phosphatase catalytic subunits. While PP2C seems to be different from the other two, PP1, PP2A, and PP2B, all three of these enzymes are members of the same gene family. A diverse group of enzymes known as alkaline phosphatases is found in abundance in mammalian cells. Following the general equation, acid phosphatase enzymes catalyze the hydrolysis of phosphate monoesters.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V1929 | (-)-p-Bromotetramisole Oxalate | 62284-79-1 | p-Bromotetramisole Oxalate (also known as L-p-Bromotetramisole Oxalate)is a potent,cell-permeable and non-specific alkaline phosphatase inhibitor. |
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V32191 | (1S,2S,3R)-DT-061 | 1809427-20-0 | 1S,2S,3R)-DT-061 is an isomer/enantiomer of DT-061 (DT061), which is a novel and orally bioavailable activator of protein phosphatase 2A (PP2A) and may be used in the therapy of KRAS-mutant and MYC-driven tumorigenesis. |
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V73343 | (24E)-3,4-Secocucubita-4,24-diene-3,26,29-trioic acid | 329975-47-5 | (24E)-3,4-Secocucurbita-4,24-diene-3,26,29-trioic acid is a potent PTP1B inhibitor (antagonist) with IC50=0.4 μM. |
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V73349 | (3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane | 1180504-64-6 | (3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane is a homoisoflavone. |
|
V73318 | (R)-Azasetron besylate (SENS-401) | 2025360-91-0 | (R)-Azasetron besylate (SENS-401) is an orally bioactive calcineurin inhibitor. |
|
V73321 | (Rac)-RK-682 | 154639-24-4 | (Rac)-RK-682 is the racemate of RK-682 and is an inhibitor (blocker/antagonist) of protein tyrosine phosphatases (PTPases). |
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V73312 | 1-Naphthyl phosphate potassium salt | 100929-85-9 | 1-Naphthyl phosphate potassium salt is a non-specific phosphatase inhibitor. |
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V73304 | 2-Bromo-4'-hydroxyacetophenone | 2491-38-5 | 2-Bromo-4'-hydroxyacetophenone is a potent inhibitor of PTP1B with Ki of 42 μM. |
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V73333 | 2-Hydroxymethyl-3-hydroxyanthraquinone | 68243-30-1 | 2-Hydroxymethyl-3-hydroxyanthraquinone is an anti-osteoporotic compound that can inhibit osteoclast tartrate-resistant acid phosphatase (TRAP) activity. |
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V73342 | 3,5-Difluoro-L-tyrosine | 73246-30-7 | 3,5-Difluoro-L-tyrosine is a functional, tyrosinase-resistant mimetic of tyrosine that may be utilized to analyze the substrate specificity of protein tyrosine phosphatase (PTP). |
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V3941 | 3α-AMINOCHOLESTANE (3AC) | 2206-20-4 | 3α-Aminocholestane (also known as 3AC) is a potent and selectiveSH2 domain-containing inositol-5′-phosphatase 1(SHIP1) inhibitor with immunomodulatory and antitumor effects. |
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V73319 | 4-Methylumbelliferyl phosphate disodium (4-MUP disodium; MUP disodium) | 22919-26-2 | 4-Methylumbelliferyl phosphate (4-MUP) disodium is an anionic organophosphate and a fluorescent substrate for acidic and alkaline phosphatase (phosphatase). |
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V73311 | 5-FAM-Alkyne | 510758-19-7 | 5-FAM-Alkyne is a selective and sensitive fluorescent biomarker that may be utilized to label alkaline phosphatase (ALP). |
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V73286 | 5MPN | 47208-82-2 | 5MPN is a first-in-class, orally bioactive and selective inhibitor of fructose-6-phosphate 2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4). |
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V77488 | [pTyr5] EGFR (988-993) (TFA) | [pTyr5] EGFR (988-993) TFA is derived from the autophosphorylation site (Tyr992) of the epidermal growth factor receptor (EGFR 988-993). | |
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V73326 | ALP/Carbonic anhydrase-IN-1 | 2091887-74-8 | ALP/Carbonic anhydrase-IN-1 (Compound 1e) is a dual (bifunctional) inhibitor of carbonic anhydrase (CA) and alkaline phosphatase (ALP). |
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V73339 | Anticancer agent 142 | 2948338-60-9 | anti-cancer compound 142 (compound 235) is a PTPN inhibitor (antagonist) with potential for cancer research. |
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V73351 | Anticancer agent 143 | 2948339-38-4 | Anticancer agent 143 (compound 369) is a PTPN2/PTP1B dual (bifunctional) inhibitor (antagonist) with IC50s <2.5 nM. |
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V73320 | Anticancer agent 144 | 2948340-59-6 | Anticancer agent 144 (Compound 444) is a PTPN2/PTP1B dual (bifunctional) inhibitor (antagonist) with IC50s <2.5 nM. |
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V41671 | APS-5 | 193884-53-6 | APS-5 is a chemiluminescent substratebased on 9, 10-dihydroacridine, and is mainly used for ELISA detection of compounds with alkaline phosphatase AP conjugation. |
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