Nearly all mammalian tissues contain butyrylcholinesterase (BuChE; acylcholine acylhydrolase), a serine hydrolase also known as nonspecific cholinesterase or pseudocholinesterase and with the highest levels found in plasma and liver. Acetylcholine, as well as all substances containing ester bonds, including anesthetics like succinylcholine and procaine, as well as illicit drugs like cocaine and heroin, are hydrolyzed by BChE. BChE is connected to neurons in the brain's glia and white matter, especially in the hippocampus, amygdala, and thalamus. The discovery of BChE in amyloid plaques and neurofibrillary tangles (NFTs) raises the possibility that the protein plays a role in the pathogenesis of Alzheimer's disease.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V20252 | Drofenine hydrochloride | 548-66-3 | Drofenine hydrochloride is a potent anticholinergic drug acting as an inhibitor of BChE with a kiof 3 uM. |
|
V40091 | Vasicine HCl | 7174-27-8 | Vasicine HCl (peganine)is a naturally occuring alkaloid /quinazoline alkaloid isolated fromJusticia adhatoda. |
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