CXCRs (CXC chemokine receptors) are membrane-integral proteins that bind and react to particular members of the CXC chemokine family of cytokines. They belong to a large family of G protein-linked receptors known as seven transmembrane (7-TM) proteins because they span the cell membrane seven times. They are one subfamily of chemokine receptors. CXCR1 through CXCR7 are the seven CXC chemokine receptors that are currently recognized in mammals.The CXC chemokine receptors CXCR1 and CXCR2 recognize CXC chemokines that have an E-L-R amino acid motif right next to their CXC motif. The majority of CXCR3-expressing cells are T lymphocytes. Like CCR5, CXCR4 is the receptor for a chemokine called CXCL12 (also known as SDF-1), and it is used by HIV-1 to enter target cells.The B cell-specific chemokine receptor CXCR5 plays a role in lymphocyte homing and the maturation of healthy lymphoid tissue. Prior to being given the name CXCR6, CXCR6 was known by three different names (STRL33, BONZO, and TYMSTR) because of its chromosomal location and similarity to other chemokine receptors in its gene sequence. CXCR7 was previously known as RDC-1 (an orphan receptor), but after it was discovered that CXCL12 (the ligand for CXCR4) causes chemotaxis in T lymphocytes, this molecule was renamed to CXCR7.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V51664 | (R,R)-CXCR2-IN-2 | 1838123-22-0 | CXCR2 antagonist |
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V51648 | (±)-AMG-487 | 947536-03-0 | racemate of AMG-487; CXCR3 inhibitor |
|
V51677 | Ac-Pro-Gly-Pro-OH | 292171-04-1 | Ac-Pro-Gly-Pro-OH is an endogenous hydrolyzate of extracellular collagen and works as a CXCR2 agonist. |
|
V51673 | ACT-672125 | 1449367-94-5 | ACT-672125 is a potent CXCR3 antagonist (inhibitor) with IC50 of 239 nM in human blood. |
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V51030 | ACT-777991 | ACT-777991 is a selective, orally bioactive CXCR3 antagonist. | |
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V51649 | ACT-777991 | 1967811-46-6 | ACT-777991 is a selective CXCR3 antagonist. |
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V3827 | AMD 3465 | 185991-24-6 | AMD3465 (AMD-3465) is a novel monomacrocyclic antagonist of CXCR4 with potential anticancer and anti-HIV activity. |
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V2749 | AMD 3465 hexahydrobromide | 185991-07-5 | AMD3465 hexahydrobromide (AMD-3465; GENZ-644494 6-HBr) is a novel monomacrocyclic antagonist of CXCR4 that has potential anticancer and anti-HIV activity. |
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V2055 | AMG 487 | 473719-41-4 | AMG-487 (AMG487) is a novel, potent, selective and oral antagonist of chemokine receptor 3CXCR3 with potential immunomodulatory and antiinflammatory activities. |
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V51671 | Antileukinate | 138559-60-1 | Antilebumin is a hexapeptide that is a potent activator of the CXC chemokine receptor (CXCR). |
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V2585 | ATI-2341 | 1337878-62-2 | ATI-2341 (ATI2341), a pepducin targeting the C-X-C chemokine receptor type 4 (CXCR4), is a novel and selective allosteric agonist of CXCR4 with anti-inflammatory and anticancer activity. |
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V77233 | ATI-2341 TFA | ATI-2341 is a potent, functionally selective allosteric agonist of CXC chemokine receptor type 4 (CXCR4) that works as a biasing ligand, favoring Gα1 activation over Gα13. | |
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V3257 | AZD5069 | 878385-84-3 | AZD-5069 (AZD5069) is a novel and potent CXCR2 chemokine receptor antagonist with potential anticancer and antiinflammatory activities. |
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V3799 | AZD8797 | 911715-90-7 | AZD8797 (AZD-8797) is a novel, selective, orally bioavailable and allosteric non-competitive modulator of the human CX3CR1 receptor with potential anti-Inflammatory and immunomodulatory activity. |
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V7199 | Balixafortide (POL6326) | 1051366-32-5 | Balixafortide(POL-6326),a synthetic cyclopeptide derived from polyphemusin,is a novel, potent and orally bioavailable inhibitor of CXC chemokine receptor 4 (CXCR4,IC 50=10 nM) with anticancer activity. |
|
V5009 | Burixafor HBr | 1191450-19-7 | Burixafor HBr, the hydrobromide salt of Burixafor (TG-0054), is a novel, potent and orally bioavailable antagonist of CXCR4 (CXC chemokine receptor 4) with potential anti-inflammatory activity. |
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V78682 | CCR7 antagonist 1 | CCR7 antagonist 1 (30c) is a dual antagonist of CXCR2 (IC50 = 11.02 μM) and CCR7 (IC50 = 0.43 μM). | |
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V53953 | Corydalmine (L-Corydalmine; TLZ-16) | 30413-84-4 | Corydalmine (L-Corydalmine) inhibits spore germination of certain plant pathogens and saprophytic fungi. Corydalmine is orally active and has been studied for pain relief. |
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V51676 | CTCE-0214 | 577782-52-6 | CTCE-0214 is a CXCR4 (chemokine CXC receptor 4) agonist and SDF-1α peptide analog. |
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V51125 | CTCE-9908 | 1030384-98-5 | CXCR4 antagonist |
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