|
V1341
|
BMS-833923 (XL-139) |
1059734-66-5 |
BMS-833923 (also known as XL139; BMS833923; XL-139; BMS 833923) is a novel, potent, selective, andorally bioavailable inhibitor of SMO (Smoothened) with potential antineoplastic activity. |
|
V1332
|
Cyclopamine (11-Deoxojervine) |
4449-51-8 |
Cyclopamine (formerly HSDB3505; HSDB-3505; 11-deoxojervine),a naturally occuring steroid alkaloid found in Veratrum plant, is reported to be a potent and specific inhibitor of Hedgehog (Hh) signaling pathway with both anticancer and teratogenic activities. |
|
V1337
|
GANT61 |
500579-04-4 |
GANT61 (GANT 61; nsc 136476; GANT-61; nsc-136476) is a novel and potent small-molecule inhibitor for GLI1 (glioma-associated oncogene 1) and GLI2-induced transcription with potential anticancer activity. |
|
V1339
|
Glasdegib (PF-04449913) |
1095173-27-5 |
Glasdegib (formerly known as PF-04449913; PF4449913; PF04449913; PF-4449913; Daurismo) is a novel, potent, and orally bioavailable small-molecule inhibitor of Smoothened (Smo) in the Hedgehog (Hh) signaling pathway with potential antitumor activity. |
|
V69865
|
Hedgehog IN-2 |
1126365-74-9 |
Hedgehog IN-2 (Compound 20) is a Hedgehog pathway inhibitor (antagonist) with IC50 of less than 0.003 μM in C3H10T1/2 cells. |
|
V69864
|
Hedgehog IN-3 |
1128191-09-2 |
Hedgehog IN-3 (Compound 3) is a hedgehog pathway inhibitor (IC50 = 0.01 µM). |
|
V69860
|
Hedgehog IN-5 |
1544681-93-7 |
Hedgehog IN-5 is an orally bioactive small molecule inhibitor of the hedgehog pathway. |
|
V1333
|
LDE225 (NVP-LDE225, Erismodegib) |
956697-53-3 |
Erismodegib (formerly LDE-225; NVP LDE-225; LDE225; NVP-LDE22; Sonidegib; trade name of Odomzo) is an orally bioavailable small-molecule antagonist of the Smoothened (Smo) in Hedgehog signaling pathway with potential antitumor activity. |
|
V1336
|
PF-5274857 |
1373615-35-0 |
PF-5274857 (PF5274857; PF 5274857) is a novel, potent, orally bioavailable and selective Smoothened (Smo) antagonist with potential antineoplastic activity. |
|
V1335
|
Purmorphamine |
483367-10-8 |
Purmorphamine (also called Shh Signaling Antagonist VI) is a potentpurine-based agonist ofthe hedgehog signaling pathway-smoothened receptor with an EC50of 1 μM. |
|
V69135
|
RL-0070933 |
301326-41-0 |
RL-0070933 is an effective ciliary regulator. |
|
V69861
|
RU-SKI 43 hydrochloride (RU-SKI 43 (hydrochloride)) |
1782573-67-4 |
RU-SKI 43 HCl is a potent and specific inhibitor of hedgehog acyltransferase (Hhat) with IC50 of 850 nM. |
|
V69863
|
SANT 2 |
329196-48-7 |
SANT 2 is a potent antagonist of the Hh signaling pathway. |
|
V1340
|
SANT-1 |
304909-07-7 |
SANT-1 (SANT1; SANT 1) is a novel, potent and selective Sonic hedgehog (Shh) enzyme inhibitor/Smo antagonist with potential antineoplastic activity. |
|
V1338
|
Smoothened Agonist (SAG) |
912545-86-9 |
Smoothened Agonist (SAG), a benzothiophene analog, is a potent and cell-permeable Smoothened (Smo) agonist with EC50 of 3 nM in Shh-LIGHT2 cells. |
|
V1334
|
Taladegib (LY2940680) |
1258861-20-9 |
Taladegib (formerly LY2940680, LY 2940680, LY-2940680) is a potent and orally bioavailable Hedgehog pathway antagonist of the smoothened receptor being developed by Eli Lilly for the treatment of cancer. |
|
V1331
|
Vismodegib (GDC-0449) |
879085-55-9 |
Vismodegib (formerly known as GDC-0449; RG-3616; GDC0449; RG3616; trade name: Erivedge) is a potent, orally bioavailable, first-in-class and specific hedgehog pathway inhibitor with potential anticancer activity. |