Neurohypophysial hormone arginine vasopressin (AVP) regulates body fluid homeostasis, causes vasoconstriction, and releases adrenocorticotropic hormone, among other things. Three subtypes of vasopressin receptors—designated V1a, V1b (or V3), and V2—mediate these physiological effects. They are all members of the large family of G-protein-coupled receptors that resemble rhodopsin.
The V1a receptor stimulates hepatic glycogenolysis, platelet aggregation, coagulation factor release, and cell contraction and proliferation. It is expressed in both neuronal and non-neuronal tissues, including the heart. The pituitary gland is the primary site of the V1b receptor subtype, which is responsible for stimulating the release of adrenocorticotropic hormone. The G protein alpha-subunit of the Gαq family (αq, q11, q14, α15/16) is the mechanism by which the V1a and V1b AVP receptors activate phospholipase C-β, raising the levels of calcium and IP3 in cells. On the other hand, the V2 receptor subtype is primarily found in the kidney, where it activates adenylyl cyclase and mediates the anti-diuretic effects of AVP via the heterotrimeric G protein Gs.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V74547 | (d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin (SKF 100273) | 73168-24-8 | (d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin (SKF 100273) is a vasopressin V1 receptor selective antagonist. |
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V74535 | (d(CH2)51,Tyr(Me)2,Dab5,Arg8)-Vasopressin (d(CH2)5[Tyr(Me)2, Dab5]AVP) | 176714-12-8 | (d(CH2)51,Tyr(Me)2,Dab5,Arg8)-Vasopressin (d(CH2)5[Tyr(Me)2, Dab5]AVP) is a specific vasopressin receptor V1a antagonist agent, the pA2 value was 6.71. |
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V74540 | (D-Arg8)-Inotocin | 745816-74-4 | (D-Arg8)-Inotocin is a specific and competitive vasopressin receptor V1aR antagonist (inhibitor) with a Ki of 1.3 nM. |
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V77425 | (Phe2,Orn8)-Oxytocin acetate | (Phe2,Orn8)-Oxytocin acetate is a selective V1 vasopressin agonist. | |
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V74534 | (Phenylac1,D-Tyr(Et)2,Lys6,Arg8,des-Gly9)-Vasopressin | 129520-65-6 | (Phenylac1,D-Tyr(Et)2,Lys6,Arg8,des-Gly9)-Vasopressin is a potent vasopressin V1 receptor (VP V1R) antagonist. |
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V74542 | [Asu1,6-Arg8]Vasopressin | 40944-53-4 | [Asu1,6-Arg8]Vasopressin is a vasopressin agonist that enhances corticotropin-releasing factor (CRF)-induced cyclic AMP accumulation and ACTH release in cultured rat anterior pituitary cells. |
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V74538 | [Deamino-Pen1,Val4,D-Arg8]-vasopressin | 64158-84-5 | [Deamino-Pen1,Val4,D-Arg8]-vasopressin (AVP-A) is an arginine vasopressin (AVP) antagonist. |
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V77957 | Antagonist G TFA | Antagonist G TFA is a potent vasopressin antagonist. | |
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V12273 | Balovaptan | 1228088-30-9 | Balovaptan (RG7314; RG-7314; RO-5285119) is a novel potent andbrain-penetrant vasopressin 1a (hV1a) receptor antagonist with the potential to be used for autism. |
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V74531 | Big Endothelin-1 (1-38), human | 120796-97-6 | Big Endothelin-1 (1-38), human is the precursor of endothelin-1. |
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V74537 | Big Endothelin-1 (1-39), porcine | 120796-99-8 | Big Endothelin-1 (1-39), porcine is the precursor of endothelin-1. |
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V1484 | Conivaptan HCl (YM 087) | 168626-94-6 | Conivaptan HCl (formerly known as YM-087; YM087; YM 087, trade name Vaprisol), the hydrochloride salt of Conivaptan, is an orally bioavailable and non-peptide antagonist of vasopressin V1A and V2 receptors with anti-hypernatremic activity. |
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V74532 | d[Cha4]-AVP | 500170-27-4 | d[Cha4]-AVP is a potent and specific vasopressin (AVP) V1b receptor agonist/activator with a Ki of 1.2 nM for the human V1b receptor. |
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V78994 | d[Cha4]-AVP TFA | d[Cha4]-AVP TFA is a potent and specific vasopressin (AVP) V1b receptor agonist/activator with a Ki of 1.2 nM for the human V1b receptor. | |
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V74541 | D[LEU4,LYS8]-VP | 42061-33-6 | D[LEU4,LYS8]-VP is a selective agonist of vasopressin V1b receptor, with Kis of 0.16 nM, 0.52 nM and 1.38 nM for rat, human and mouse V1b receptor respectively. |
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V77111 | D[LEU4,LYS8]-VP TFA | D[LEU4,LYS8]-VP TFA is a selective agonist of vasopressin V1b receptor, with Kis of 0.16 nM, 0.52 nM and 1.38 nM for rat, human and mouse V1b receptor respectively. | |
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V74544 | Desamino(D-3-(3′-pyridyl)-Ala2,Arg8)-Vasopressin | 136105-89-0 | Desamino(D-3-(3′-pyridyl)-Ala2,Arg8)-Vasopressin is a synthetic analog of antidiuretic hormone (AVP) and a weak agonist of antidiuretic receptors. |
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V74536 | Dp[Tyr(methyl)2,Arg8]-Vasopressin | 67269-08-3 | Dp[Tyr(methyl)2,Arg8]-Vasopressin is a non-selective peptide arginine vasopressin Vlb receptor blocker (antagonist). |
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V74543 | Enuvaptan (BAY-2327949) | 2145062-48-0 | Enuvaptan (BAY-2327949) is a vasopressin receptor blocker (antagonist) with potential for studying renal and cardiovascular diseases. |
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V74549 | F992 | 162277-99-8 | F992 is an antidiuretic peptide and vasopressin (antidiuretic hormone) analog. |
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