STAT is a family of cytoplasmic protein that regulates many aspects of growth, survival and differentiation in cells. The Janus kinase family of transcription factors is activated, and dysregulation of this pathway, which promotes angiogenesis, tumor survival, and immunosuppression, is frequently seen in primary tumors. Gene knockout studies have shown that STAT proteins are important for immune system development and operation, immune tolerance maintenance, and tumor surveillance.Initially, STAT proteins were thought to be dormant cytoplasmic transcription factors that needed to be phosphorylated in order to be retained in the nucleus. While awaiting an activation signal, the unphosphorylated STAT proteins move back and forth between the cytosol and the nucleus. The transcription of cytokine-inducible genes is activated once the activated transcription factor enters the nucleus and binds to the consensus DNA-recognition motif known as gamma-activated sites (GAS) in the promoter region.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V69139 | (R)-Lisofylline ((R)-Lisophylline) | 100324-81-0 | (R)-Lisofylline ((R)-Lisophylline) is the (R)-enantiomer of the Pentoxifylline metabolite and has anti-inflammatory activities. |
|
V69136 | Angoline | 21080-31-9 | Angoline is a potent and specific inhibitor of the IL6/STAT3 signaling pathway with IC50 of 11.56 μM. |
|
V69143 | Angoline hydrochloride | 1071676-04-4 | Angoline HCl is a potent and specific inhibitor of the IL6/STAT3 signaling pathway with IC50 of 11.56 μM. |
|
V69156 | Antitumor agent-73 | 2812356-72-0 | Antitumor agent-73 is an analogue of Diosgenin, which can inhibit the STAT3 signaling pathway and exogenously activate Pdia3/ERp57. |
|
V69144 | APT STAT3 | 1345420-96-3 | APT STAT3 is a specific STAT3-binding peptide. |
|
V2003 | Artesunate | 88495-63-0 | Artesunate (Amivas; SM-804; WR-256283; HSDB-7458;Armax 200), an approved antimalaria agent, is a semisynthetic derivative of artemisinin with an IC50 of < 5 μM for small cell lung carcinoma cell line H69. |
|
V2981 | AS1517499 | 919486-40-1 | AS1517499 is a potent STAT6 inhibitor with IC50of 21 nM. |
|
V2547 | BP-1-102 | 1334493-07-0 | BP-1-102 is a potent, orally bioavailable and selective STAT3 inhibitor, which binds Stat3 with an affinity Kd of 504 nM. |
|
V4972 | Cucurbitacin I | 2222-07-3 | Cucurbitacin I, a naturally occurring triterpene analog, is a novel, potent and selective inhibitor of JAK2/STAT3 with potent anti-cancer activity on a variety of cancer cell types. |
|
V69157 | Eflepedocokin alfa | 2200269-84-5 | Eflepedocokin alfa is a recombinant fusion protein with potential cytoprotective activity. |
|
V18077 | Golotimod (SCV07) | 229305-39-9 | Golotimod (Orilotimod, SCV-07), is a potent and orally bioavailable synthetic peptide with an immunomodulating and antimicrobial activities. |
|
V22020 | GYY 4137 morpholine salt | 106740-09-4 | GYY 4137 morpholine salt (GYY-4137; GYY4137; ZYJ1122; ZYJ-1122) is a novel, water-soluble and slow releasing Hydrogen sulfide (H2S) donor. |
|
V9650 | Homoharringtonine (HHT) | 26833-87-4 | Homoharringtonine (Omacetaxine mepesuccinate and HHT; trade name Synribo) is a naturally occurring and cytotoxic pharmaceutical substance that is indicated for treatment of chronic myeloid leukemia (CML). |
|
V76918 | HP590 | HP590 is an orally bioactive, novel and potent STAT3 inhibitor (STAT3 luciferase activity: IC50=27.8 nM; ATP inhibition: IC50=24.7 nM). | |
|
V22577 | inS3-54-A18 | 328998-53-4 | inS3-54A18 is a potent STAT3 inhibitor (antagonist) with anti-cancer effects. |
|
V69138 | ML115 | 912798-42-6 | ML115 is a molecular probe for signaling transducers and transcriptional activators. |
|
V2259 | Narciclasine | 29477-83-6 | Narciclasine is a plant growth regulator. |
|
V69151 | Neocucurbitacin A | 352359-53-6 | Neocucurbitacin A (compound 7) is a STAT3 inhibitor found in agarwood peel. |
|
V7042 | RO8191 | 691868-88-9 | RO8191(RO-8191; CDM-3008) is a novel and potent activator of JAK/STAT pathway andinterferon α receptor type 2 (IFNAR2) with antiviral effects. |
|
V67544 | ROCK2-IN-7 | 3000541-95-4 | ROCK2-IN-7 is a kinase inhibitor targeting ROCK2. |
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