Proteasomes are enormous protein complexes found in all eukaryotes, archaea, and some bacteria. They are found in the cytoplasm and nucleus of eukaryotes. The proteasome's primary job is to break down unwanted or damaged proteins through the process of proteolysis, which is a peptide bond-breaking chemical reaction. Proteases are enzymes that carry out these types of reactions.A key mechanism by which cells control the concentration of specific proteins and destroy improperly folded proteins includes proteasomes. When a protein is degraded, it produces peptides that are seven to eight amino acids long. These peptides can then be further broken down into amino acids and used to create new proteins. A tiny protein called ubiquitin marks proteins for degradation. The tagging process is sped up by ubiquitin ligases, an enzyme family. Once a protein has one ubiquitin molecule attached to it, other ligases know to attach more ubiquitin molecules. As a result, a polyubiquitin chain forms, which the proteasome binds to and uses to break down the tagged protein.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V2424 | 26S proteasome inhibitor I | 858557-69-4 | 20S Proteasome-IN-1 is a 26S proteasome inhibitor. |
|
V73372 | 5-Amino-8-hydroxyquinoline (5A8HQ) | 13207-66-4 | 5-Amino-8-hydroxyquinoline (5A8HQ) is a potential anticancer candidate active molecule with good proteasome inhibitory activity |
|
V73376 | Ac-ANW-AMC | 2357123-49-8 | Ac-ANW-AMC is a fluorescent substrate for immunoproteasome. |
|
V73379 | Ac-Leu-Leu-Norleucinol | 148333-42-0 | Ac-Leu-Leu-Norleucinol is a calpain inhibitor that may be utilized to study acute liver injury caused by Acetaminophen and can reduce induced levels of aspartate aminotransferase (ALT) and alanine aminotransferase (AST). |
|
V73366 | Ac-Nle-Pro-Nle-Asp-AMC | 355140-49-7 | Ac-Nle-Pro-Nle-Asp-AMC is a specific substrate of the 26S proteasome. |
|
V77743 | Acetyl-Calpastatin(184-210)(human) TFA | Acetyl-Calpastatin(184-210)(human) TFA is a specific and reversible calpain inhibitor (antagonist) with Kis of 0.2 nM and 6 μM for μ-calpain and cathepsin L respectively. | |
|
V4408 | Alicapistat | 1254698-46-8 | Alicapistat (also known as ABT957; ABT-957) is a novel, potent,selective and orally bioactive inhibitor of humancalpains 1and2whose overactivation has been linked to Alzheimer disease (AD). |
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V77981 | Anticancer agent 114 | Anticancer agent 114 is an orally bioavailable dipeptide boronate proteasome inhibitor (antagonist) with IC50 of 2.2 nM. | |
|
V60269 | BC-05 | 2260717-73-3 | BC-05 is an orally bioactive and potent inhibitor of CD13 and proteasome. |
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V73371 | Calpain Inhibitor XI | 145731-49-3 | Calpain Inhibitor XI is a reversible covalent inhibitor of calpain-1. |
|
V73377 | Calpain Inhibitor-1 | 1448429-06-8 | Calpain Inhibitor-1 (compound 36) is a potent, selective inhibitor of the cysteine protease calpain 1 (Cal1) (IC50=100 nM; Ki=2.89 μM). |
|
V51375 | Calpain-2-IN-1 | 144231-85-6 | Calpain-2-IN-1 (Formula 1A) is a potential surrogate calpain-2 isoform with Ki of 181 nM and 7.8 nM for calpain-1 and calpain-2, respectively. |
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V73382 | Calpastatin subdomain B | 128578-18-7 | Calpastatin subdomain B is a biologically active peptide. |
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V73373 | Davelizomib | 2409841-51-4 | Davelizomib is a proteasome inhibitor (antagonist) with anti-tumor effects. |
|
V73367 | Dazcapistat (BLD-2660) | 2221010-42-8 | Dazcapistat is a potent calpain inhibitor (antagonist) with IC50 of <3 μM for calpain 1, calpain 2 and calpain 9 (see patent WO2018064119A1, compound 405 for details). |
|
V2294 | DD1 inhibitor | 187585-11-1 | DD1 is a proteasome inhibitor that activates/agonizes Bax and degrades P70S6K during the apoptosis process of acute myeloid leukemia (AML). |
|
V73368 | Enzyme-IN-1 | 868540-02-7 | Enzyme-IN-1 (compound 1) is a bioactive peptide-based N-terminal nucleophile (Ntn) hydrolase inhibitor. |
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V79360 | EWFW-ACC | EWFW-ACC is a tetrapeptide substrate of the immunoproteasome and is selective for the LMP7 subunit. | |
|
V80413 | iso-VQA-ACC | iso-VQA-ACC is a constitutive proteasome substrate. | |
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V80414 | iso-VQA-ACC TFA | iso-VQA-ACC (TFA) is a constitutive proteasome substrate |
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