Cell membrane blebbing, chromatin condensation, genomic DNA fragmentation, and the exposure of particular phagocytosis signaling molecules on the cell surface are just a few of the distinctive morphological and biochemical features of the cell death process known as apoptosis. Apoptosis-initiated cell death is distinct from necrosis-induced cell death. Apoptotic death, in contrast, is silent and orderly. Necrotic cells are typically recognized as a danger signal by the immune system, which causes inflammation.
There are two main methods for inducing apoptotic cell death: The intrinsic pathway, also known as the Bcl-2-regulated or mitochondrial pathway, is strictly regulated by the BCL-2 family of proteins and is activated by a variety of developmental cues or cytotoxic insults, such as viral infection, DNA damage, and growth-factor deprivation.The tumor necrosis factor (TNF) receptor family members, such as Fas or TNF receptor-1 (TNFR1), which contain an intracellular death domain and can recruit and activate caspase-8 through the adaptor protein Fas-associated death domain (FADD; also known as MORT1) at the cell surface, are what initiate the extrinsic or death-receptor pathway. Without the involvement of the BCL-2 family, this recruitment results in the subsequent activation of downstream (effector) caspases like caspase-3, -6, or -7.
Numerous human diseases, including cancer, viral infections, autoimmune diseases, neurodegenerative disorders, and AIDS (acquired immunodeficiency syndrome), may be influenced by changes in cell survival, according to studies. Some of these diseases may not progress naturally unless specific therapies that change the apoptotic threshold are used.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V34771 | Urolithin C (urolithin C) | 165393-06-6 | Urolithin C, a polyphenolic intestinal microbial metabolite of ellagic acid, is a glucose-dependent activator of insulin secretion. |
|
V35149 | UZH1 | 2925713-02-4 | UZH1 is the racemate of UZH1a and UZH1b. |
|
V35148 | UZH1a | 2813577-78-3 | UZH1a is a potent and specific METTL3 inhibitor (antagonist) with IC50 of 280 nM. |
|
V35146 | Vallesiachotamine | 5523-37-5 | Vallesiachotamine is a well-known monoterpene indole alkaloid with anti-tumor effects |
|
V52667 | Vandetanib-d4 (vandetanib d4) | 1215100-18-7 | Vandetanib-d4 is the deuterated form of Vandetanib. |
|
V56390 | Vandetanib-d6 (ZD6474-d6) | 1174683-49-8 | Vandetanib-d6 is the deuterated form of Vandetanib. |
|
V54818 | VDRagonist 1 | 2269494-43-9 | VDR agonist 1 (compound 28) is a nonsteroidal vitamin D receptor (VDR) agonist/activator with IC50 of 690 nM measured in MCF-7 cells. |
|
V35139 | VII-31 | 2305757-96-2 | VII-31 is an activator of the NEDDylation pathway and can inhibit tumors in vitro and in vivo. |
|
V56437 | Vildagliptin-d3 (LAF237-d3; NVP-LAF 237-d3) | 1217546-82-1 | Vildagliptin-d3 is the deuterated form of Vildagliptin. |
|
V56397 | Vincristine-d3 sulfate (Leurocristine-d3 (sulfate); NSC-67574-d3 (sulfate); 22-Oxovincaleukoblastine-d3 (sulfate)) | 1246817-10-6 | Vincristine-d3 (sulfate) is the deuterated form of Vincristine sulfate. |
|
V52538 | Vincristine-d3-ester sulfate (Leurocristine-d3-ester (sulfate); NSC-67574-d3-ester (sulfate); 22-Oxovincaleukoblastine-d3-ester (sulfate)) | 1217854-24-4 | Vincristine-d3-ester (sulfate) is the deuterated form of Vincristine sulfate. |
|
V35136 | Visilizumab (Anti-Human CD3E Recombinant Antibody; HuM291) | 219716-33-3 | Visilizumab (Anti-Human CD3E Recombinant Antibody) is a humanized low Fc receptor-binding anti-CD3 monoclonal IgG2 antibody. |
|
V35135 | Vitexilactone | 61263-49-8 | Vitexilactone is a diterpenoid extracted from the leaves of Vitex negundo L. |
|
V54942 | Vitexin B-1 | 357645-16-0 | Vitexin B-1 is a Bcl-2 inhibitor and Caspase agonist. |
|
V35134 | Volasertib trihydrochloride (Volasertib trihydrochloride; BI 6727 trihydrochloride) | 946161-17-7 | Volasertib (BI 6727) tri HCl is an orally bioactive, potent, ATP-competitive inhibitor of Polo-like kinase 1 (PLK1) with IC50 of 0.87 nM. |
|
V52666 | Vorinostat-d5 (SAHA-d5; Suberoylanilide hydroxamic acid-d5) | 1132749-48-4 | Vorinostat-d5 (SAHA-d5) is the deuterium labelled form of Vorinostat. |
|
V35131 | W146 TFA | 909725-62-8 | W146 TFA is a selective antagonist of sphingosine-1-phosphate receptor subtype 1 (S1PR1) with EC50 of 398 nM. |
|
V35130 | WBC100 (14-D-Valine-TPL) | 2095780-08-6 | WBC100 (14-D-Valine-TPL) is an effective, selective, orally bioactive c-Myc molecular glue degrader. |
|
V35121 | Wu-5 | 2630378-05-9 | Wu-5 is a USP10 inhibitor that can inhibit the FLT3 and AMPK pathways, induce FLT3-ITD degradation and cause apoptosis. |
|
V53359 | Xanthoangelol | 62949-76-2 | Xanthoangelol can be extracted from Angelica keiskei and can inhibit the inflammatory response caused by obesity. |
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