Cell membrane blebbing, chromatin condensation, genomic DNA fragmentation, and the exposure of particular phagocytosis signaling molecules on the cell surface are just a few of the distinctive morphological and biochemical features of the cell death process known as apoptosis. Apoptosis-initiated cell death is distinct from necrosis-induced cell death. Apoptotic death, in contrast, is silent and orderly. Necrotic cells are typically recognized as a danger signal by the immune system, which causes inflammation.
There are two main methods for inducing apoptotic cell death: The intrinsic pathway, also known as the Bcl-2-regulated or mitochondrial pathway, is strictly regulated by the BCL-2 family of proteins and is activated by a variety of developmental cues or cytotoxic insults, such as viral infection, DNA damage, and growth-factor deprivation.The tumor necrosis factor (TNF) receptor family members, such as Fas or TNF receptor-1 (TNFR1), which contain an intracellular death domain and can recruit and activate caspase-8 through the adaptor protein Fas-associated death domain (FADD; also known as MORT1) at the cell surface, are what initiate the extrinsic or death-receptor pathway. Without the involvement of the BCL-2 family, this recruitment results in the subsequent activation of downstream (effector) caspases like caspase-3, -6, or -7.
Numerous human diseases, including cancer, viral infections, autoimmune diseases, neurodegenerative disorders, and AIDS (acquired immunodeficiency syndrome), may be influenced by changes in cell survival, according to studies. Some of these diseases may not progress naturally unless specific therapies that change the apoptotic threshold are used.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V35168 | Trigothysoid N | 1501943-08-3 | Trigothysoid N is a daphne diterpene with anti-cancer activity. |
|
V54958 | Trijuganone C | 135247-94-8 | Trijuganone C, a naturally occurring compound found in Salvia miltiorrhiza, inhibits cancer cell proliferation/growth by inducing mitochondrial dysfunction and caspase activation-mediated apoptosis. |
|
V54822 | Tripeptide-32 | 1185583-20-3 | Tripeptide-32 is a biologically active peptide with anti-aging activities that has been reported as an ingredient of cosmetics. |
|
V54901 | TRK-IN-23 | 2924344-29-4 | TRK-IN-23 (compound 24b) is a potent orally bioactive TRK inhibitor (antagonist) with IC50s of 0.5 nM, 9 nM, 14 nM, 4.4 nM and 4.8 nM for TRKA, TRKC, TRKAG595R, TRKAF589L and TRKAG667C, respectively. |
|
V54981 | TS-IN-2 | 2945983-00-4 | TS-IN-2 (compound 17) is a thymidylate synthase (TS) inhibitor (antagonist) with IC50 of 0.81 μM. |
|
V34708 | Tubulin inhibitor 11 | 2366260-33-3 | Tubulin inhibitor 11 is a potent orally bioactive tubulin inhibitor. |
|
V34707 | Tubulin inhibitor 30 | 2873383-67-4 | Tubulin inhibitor 30 (Compound 15) is a tubulin/microtubule inhibitor (antagonist) with IC50 of 0.52 μM. |
|
V34706 | Tubulin inhibitor 32 | 2923531-39-7 | Tubulin inhibitor 32 is a potent, orally bioactive microtubule (tubulin) inhibitor. |
|
V34705 | Tubulin inhibitor 33 | 2944462-67-1 | Tubulin inhibitor 33 is a tubulin polymerization inhibitor that can suppress tubulin polymerization in a dose-dependent manner with IC50 of 9.05 μM. |
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V54845 | Tubulin inhibitor 35 | 2247047-77-2 | Tubulin inhibitor 35 (compound 6b) is a dual (bifunctional) inhibitor of topoisomerase I (IC50=~50 μM) and tubulin polymerization (IC50=5.69 μM). |
|
V34709 | Tubulin polymerization-IN-41 | 2804026-81-9 | Tubulin polymerization-IN-41 is a potent inhibitor of tubulin polymerization with IC50 of 2.61 μM. |
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V35165 | Tubulin/MMP-IN-2 | 2734877-51-9 | Tubulin/MMP-IN-2 is a dual (bifunctional) inhibitor of tubulin and matrix metalloproteinases. |
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V30181 | Tubuloside B | 112516-04-8 | Tubuloside B is a naturally occurring compound extracted from the stems of Cistanche salsa that can inhibit TNFα-induced apoptosis. |
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V55021 | Tulisokibart (PRA023; PRA-023) | 2648504-55-4 | Tulisokibart (PRA023) is a humanized mouse IgG1-κ antibody targeting TNFSF15/TL1A. |
|
V4013 | Tumor targeted pro-apoptotic peptide | 1926163-30-5 | Tumor targeted pro-apoptotic peptide (CNGRC-GG-D(KLAKLAK)2) is an anti-tumor peptide. |
|
V53462 | Tylvalosin (Acetylisovaleryltylosin) | 63409-12-1 | Tylvalosin (Acetylisovaleryltylo?sin) is a broad-spectrum macrolide antibiotic with antimicrobial activity. |
|
V34700 | Ulinastatin (Uristatin; Uristatin) | 80449-31-6 | Ulinastatin (Uristatin) is a trypsin and serine protease inhibitor. |
|
V52579 | Umbelliferone-d5 (7-Hydroxycoumarin-d5; Hydrangin-d5; NSC 19790-d5) | 1215373-23-1 | Umbelliferone-d5 is the deuterated form of Umbelliferone. |
|
V55018 | Undecane | 1120-21-4 | Undecane has anti-allergic and anti-inflammatory activity against sensitized rat basophilic leukemia (RBL-2H3) mast cells and HaCaT keratinocytes. |
|
V56442 | Undecane-d24 | 164858-54-2 | Undecane-d24 is the deuterium labelled form of Undecane. |
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