RNA synthesis, which is also called DNA transcription, is a highly selective process.Beyond RNA synthesis, RNA polymerase II transcription plays a more active role in the maturation, monitoring, and export of mRNA to the cytoplasm.
In order to fully repair the DNA after a single-strand break, DNA ligase constructs the final phosphodiester bond using the complementary strand of the double helix as a template.Substrates with RNA strands or mismatched base pairs near the ends of the nicked DNA are discriminated against by DNA ligases. Bleomycin (BLM) is a S-independent radiomimetic agent that damages DNA by creating free radicals that attack the C-4′ position in the deoxyribose backbone. This causes the ribose ring to open and strand breaks to occur.
M-MuLV Reverse Transcriptase (RNase H) and random hexamer primers are used to create first strand cDNA. The next step involves the use of DNA Polymerase I and RNase H to create second strand cDNA. Exonuclease/polymerase activity transforms the remaining overhangs into blunt ends. DNA fragments' 3′ ends are adenylated before being ligated with a NEBNext Adaptor with a hairpin loop structure to get the samples ready for hybridization. The two pathways that BET bromodomain inhibition most commonly affects are cell cycle and DNA replication. The translation of mRNA into proteins is inhibited by cycloheximide.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V35184 | Tofersen (BIIB067; ISIS-SOD1Rx) | 2088232-70-4 | Tofersen (BIIB067; Qalsody) is an antisense oligonucleotide that facilitates the degradation of superoxide dismutase 1 (SOD1) mRNA in an RNase H-dependent manner, thereby lowering the synthesis of SOD1 protein. Tofersen is employed in research pertaining to amyotrophic lateral sclerosis (ALS). |
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V1441 | Triapine (PAN-811; 3-AP) | 143621-35-6 | Triapine (formerly NSC-663249; AIDS-179996; AP; OCX191; PAN-811; OCX-191; 3AP; NSC663249; PAN811; 3-AP; PAN 811)is a so-called ribonucleotide reductase inhibitor being investigated for cancer treatment. |
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V1461 | Trifluridine (trifluorothymidine) | 70-00-8 | Trifluridine (alsoknown astrifluorothymidine; FTD; NSC-529182;NSC-75520;NSC529182; NSC75520; Viroptic), an inhibitor of the thymidylate synthase and DNA synthesis, is an approved anti-herpesvirus antiviral agent/medications used mainly for treating infections in the eye. |
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V55134 | Trimidox (VF-233) | 95933-74-7 | Trimidox (VF-233) is an antileukemic ribonucleotide reductase inhibitor. |
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V35045 | UCK2 Inhibitor-3 | 2376687-49-7 | UCK2 Inhibitor-3 is a non-competitive inhibitor of uridine cytidine kinase 2 (UCK2) with an IC50 value of 16.6 μM. |
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V76387 | UNC9512 | UNC9512 is a potent methyl-lysine reader p53-binding protein 1 (53BP1) antagonist. | |
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V81675 | Uracil-m7GpppAmpG ammonium | Uracil-m7GpppAmpG ammonium is a cap analog that may be utilized in mRNA synthesis. | |
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V1474 | Uridine (NSC 20256) | 58-96-8 | Uridine (formerly NSC 20256; NSC-20256; NSC20256)is a glycosylated pyrimidine-analog containing uracil attached to a ribose ring, specifically, a ribofuranose, via a β-N1-glycosidic bond. |
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V1460 | Vidarabine (Ara-A) | 5536-17-4 | Vidarabine(Ara-A; Adenine Arabinoside; 9-β-D-Arabinofuranosyladenine; Arabinofuranosyladenine) is an approved antiviral drug that interfers with the synthesis of viral DNA, and is mainly used to treat HSV and VZV: herpes simplex and varicella zoster viruses. |
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V55127 | Votoplam | 2407849-89-0 | Votoplam is a gene splicing modulator used to inhibit Huntington's disease. |
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V50998 | WAY-326359 | 870757-46-3 | WAY-326359 is a novel and selective APE1 inhibitor. |
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V35129 | Werner syndrome RecQ helicase-IN-1 | 2869954-34-5 | Werner syndrome RecQ helicase-IN-1 (example 42) is a novel DNA helicase (WRN) inhibitor for Werner syndrome RecQ that has potential applications in cancer research. |
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V35128 | Werner syndrome RecQ helicase-IN-2 | 2869954-51-6 | Werner syndrome RecQ helicase-IN-2 (example 57) is a novel DNA helicase (WRN) inhibitor for Werner syndrome RecQ intended for use in cancer research. |
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V35127 | Werner syndrome RecQ helicase-IN-3 | 2869954-98-1 | Werner syndrome RecQ helicase-IN-3 is a potent orally active Werner syndrome RecQ DNA helicase WRN inhibitor with an IC50 value of 0.06 μM. |
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V35126 | Werner syndrome RecQ helicase-IN-4 | 2869954-53-8 | Werner syndrome RecQ helicase-IN-4 is a selective Werner syndrome RecQ DNA helicase WRN inhibitor with an IC50 value of 0.06 μM. |
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V55124 | WRN inhibitor 1 | 2923008-44-8 | WRN inhibitor 1 (example 7) is an ATP-dependent helicase WRN inhibitor that inhibits the activity of the WRN helicase domain and is beneficial in treating Werner syndrome. |
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V55135 | WRN inhibitor 2 | 2923009-56-5 | WRN inhibitor 2 (example 118) is a WRN (Werner syndrome ATP-dependent helicase) inhibitor (antagonist) with pIC50 ≥ 7.0. |
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V29980 | Xanthopterin (hydrate) | 5979-01-1 | Xanthopterin hydrate is a pteridine-based compound and a main component foudn in the yellow granule in the Oriental hornet bear wings, produces a characteristic excitation/emission maximum at 386/456 nm. |
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V55160 | Xanthosine-5'-Triphosphate (5'-XTP) | 6253-56-1 | Xanthosine-5'-Triphosphate (5'-XTP) is a nucleotide generated by deamination of purine bases. |
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V1436 | YK-4-279 | 1037184-44-3 | YK-4-279 (YK-4279; YK4279;YK4-279; YK 4-279) is a potent inhibitor of EWS-FLI1 binding to RNA helicase A (RHA) with potential anticancer activity. |
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