RNA synthesis, which is also called DNA transcription, is a highly selective process.Beyond RNA synthesis, RNA polymerase II transcription plays a more active role in the maturation, monitoring, and export of mRNA to the cytoplasm.
In order to fully repair the DNA after a single-strand break, DNA ligase constructs the final phosphodiester bond using the complementary strand of the double helix as a template.Substrates with RNA strands or mismatched base pairs near the ends of the nicked DNA are discriminated against by DNA ligases. Bleomycin (BLM) is a S-independent radiomimetic agent that damages DNA by creating free radicals that attack the C-4′ position in the deoxyribose backbone. This causes the ribose ring to open and strand breaks to occur.
M-MuLV Reverse Transcriptase (RNase H) and random hexamer primers are used to create first strand cDNA. The next step involves the use of DNA Polymerase I and RNase H to create second strand cDNA. Exonuclease/polymerase activity transforms the remaining overhangs into blunt ends. DNA fragments' 3′ ends are adenylated before being ligated with a NEBNext Adaptor with a hairpin loop structure to get the samples ready for hybridization. The two pathways that BET bromodomain inhibition most commonly affects are cell cycle and DNA replication. The translation of mRNA into proteins is inhibited by cycloheximide.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V55198 | N4-Bz-5'-O-DMTr-3'-deoxy-3'-fluoro-beta-D-xylofuranosyl cytidine-2'-CED-phosphoramidite | 1555759-30-2 | N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-3'-deoxy-3'-fluoro-beta-D-xylofuranosyl cytidine-2'-CED-phosphoramidite is a phosphoramidite monomer, Can be used for solid-phase synthesis of oligonucleotides. |
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V55206 | N6-Benzoyl-2'-deoxy-5'-O-DMT-a-adenosine 3'-CE phosphoramidite | 152695-84-6 | N6-Benzoyl-2'-deoxy-5'-O-DMT-a-adenosine 3'-CE phosphoramidite is a phosphoramidite monomer that may be utilized in the preparation /synthesis of oligonucleotides. |
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V55118 | N7-Methyl-guanosine-5'-triphosphate-5'-adenosine (m7GpppA) | 62828-63-1 | N7-Methyl-guanosine-5'-triphosphate-5'-adenosine (m7GpppA) is a dinucleotide cap analog for in vitro RNA transcription. |
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V53208 | N7-Methyl-guanosine-5'-triphosphate-5'-adenosine diammonium (m7GpppA diammonium) | 75252-10-7 | N7-Methyl-guanosine-5'-triphosphate-5'-adenosine (m7GpppA) diammonium is a dinucleotide cap analog for in vitro RNA transcription. |
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V41133 | NCGC00029283 | 714240-31-0 | NCGC00029283 is a novel inhibitor of Werner syndrome helicase-nuclease (WRN) with IC50s of 2.3 μM, 12.5 μM, and 3.4 μM for WRN, BLM, and FANCJ helicases, respectively. |
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V1471 | Nedaplatin (NSC 375101D) | 95734-82-0 | Nedaplatin (formerly NSC-375101D; NSC 37510D;NSC-375101 D;NSC 375101-D; trade name Aqupla) is a cisplatin analog and DNA damaging agent approved as an anticancer medication. |
|
V1455 | Nelarabine (Arranon; 506U78) | 121032-29-9 | Nelarabine (formerly 506 U78; GW-506U78; NS-686673; 506U78; GW506U78; Atriance; Arranon; Nelzarabine) is a cytotoxic/chemotherapeutic medication approved for use in the treatment of hematological malignancies (T-cell acute lymphoblastic leukemia and T-cell lymphoblastic lymphoma). |
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V14759 | Neobavaisoflavone | 41060-15-5 | Neobavaisoflavone is a naturally occurring flavonoid isolated from the seeds of Psoralea corylifolia with anti-inflammatory, anti-cancer and anti-oxidation activities. |
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V5089 | Nimustine HCl (ACNU) | 55661-38-6 | Nimustine hydrochloride (also known as ACNU), an approved chemotherapeutic drug, is a potent DNA cross-linking and DNA alkylating agent for cancer treatment, it induces DNA replication blocking lesions and DNA double-strand breaks and inhibitsDNA synthesis, commonly used in chemotherapy for especially glioblastomas / malignant brain tumors. |
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V41105 | NITD-2 | 1197896-79-9 | NITD-2 is an inhibitor of the dengue virus (DENV) polymerase that prevents the DENV RdRp protein from causing RNA elongation. |
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V31979 | NKP-1339 (IT-139; KP-1339) | 197723-00-5 | NKP-1339(IT139; KP1339) is the first-in-class and potent ruthenium-based anticancer drug under clinical investigation for treating solid cancer with limited side effects. |
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V41094 | NSC 617145 | 203115-63-3 | NSC 617145 is a selective inhibitor of Werner syndrome helicase (WRN) helicase with an IC50 value of 230 nM. |
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V51607 | NSC-80467 | 101982-51-8 | NSC 80467 is a DNA damaging agent and selectively inhibits survivin. |
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V53143 | NSC639828 | 134742-26-0 | NSC639828 is a selective inhibitor of DNA polymerase α with an IC50 of 70 μM. NSC639828 exhibits strong antitumor properties. |
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V55131 | Nuclease S1 | 37288-25-8 | Nuclease S1 is an endonuclease that specifically breaks down RNA and single-stranded DNA (ssDNA). |
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V0057 | Oxaliplatin (Eloxatin; L-OHP; JM-83; RP-54780; SR-96669) | 61825-94-3 | Oxaliplatin (Eloxatin; L-OHP; JM83; RP54780; SR96669),an anticancer drug used for treating colorectal cancer,is an organoplatinum complex (1,2-diaminocyclohexane (DACH) and with an oxalate ligand), acnting by inhibiting DNA synthesis by forming DNA adducts in RT4, TCCSUP, A2780, HT-29, U-373MG, U-87MG, SK-MEL-2, and HT-144 cells. |
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V56311 | Oxolinic acid-d5 (oxolinic acid d5) | 1189890-98-9 | Oxolinic acid-d5 is the deuterated product of Oxolinic acid. |
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V0846 | Pemetrexed disodium | 150399-23-8 | Pemetrexed disodium (formerly HSDB-7316; LY-231514; Alimta), the disodium salt ofPemetrexed, is a marketed anticancer drug of the antifolate and antimetabolite class. |
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V2481 | pentixather | Desription: Pentixather, structurally similar to PentixaFor, is an iodinated form of PentixaFor which is a ligand/intermediate used for the preparation of gallium Ga 68-pentixafor. | |
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V19201 | PFM01 | 1558598-41-6 | PFM01 is a nuclease-specific MRE11 inhibitor. |
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