RNA synthesis, which is also called DNA transcription, is a highly selective process.Beyond RNA synthesis, RNA polymerase II transcription plays a more active role in the maturation, monitoring, and export of mRNA to the cytoplasm.
In order to fully repair the DNA after a single-strand break, DNA ligase constructs the final phosphodiester bond using the complementary strand of the double helix as a template.Substrates with RNA strands or mismatched base pairs near the ends of the nicked DNA are discriminated against by DNA ligases. Bleomycin (BLM) is a S-independent radiomimetic agent that damages DNA by creating free radicals that attack the C-4′ position in the deoxyribose backbone. This causes the ribose ring to open and strand breaks to occur.
M-MuLV Reverse Transcriptase (RNase H) and random hexamer primers are used to create first strand cDNA. The next step involves the use of DNA Polymerase I and RNase H to create second strand cDNA. Exonuclease/polymerase activity transforms the remaining overhangs into blunt ends. DNA fragments' 3′ ends are adenylated before being ligated with a NEBNext Adaptor with a hairpin loop structure to get the samples ready for hybridization. The two pathways that BET bromodomain inhibition most commonly affects are cell cycle and DNA replication. The translation of mRNA into proteins is inhibited by cycloheximide.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V81432 | SRE-II | SRE-II, an amide analogue, is an activatable photosensitizer with reduced fluorescence and photosensitizing capabilities for use in photodynamic cancer research. | |
|
V1856 | Streptozotocin (STZ) | 18883-66-4 | Streptozotocin (also known as NSC-85998, STZ, Streptozotocin; U 9889) is a glucosamine-nitrosourea derivative and a potent DNA-methylating agent with IC50s of 11.7, 904 and 1024 μg/mL in HL60, K562 and C1498 cells respectively. |
|
V35240 | Synucleozid hydrochloride (NSC 377363 hydrochloride) | 2741856-68-6 | Synucleozid (NSC 377363) is a novel inhibitor of SNCA mRNA encoding alpha-synuclein. |
|
V35272 | T-2513 | 288247-87-0 | T-2513 is a potent topoisomerase I inhibitor. |
|
V35271 | T-2513 hydrochloride | 187793-52-8 | T-2513 hydrochloride is a potent topoisomerase I inhibitor. |
|
V35232 | T2AA | 1380782-27-3 | T2AA is a monoubiquitinated proliferating cell nuclear antigen (PCNA) inhibitor that induces G1 cell cycle arrest, increases the formation of double-strand breaks (DSBs), and inhibits DNA repair. |
|
V81495 | T4 RNA ligase | T4 RNA ligase is an RNA ligase that catalyzes the ligation of single-stranded DNA molecules. | |
|
V81496 | T4 UvsX Recombinase | T4 UvsX Recombinase helps initiate DNA replication on double-stranded DNA templates by catalyzing the synapse between the template and a homologous DNA single strand that serves as a primer. | |
|
V55150 | T7 RNA polymerase | 9014-24-8 | T7 RNA polymerase is a polymerase that is produced by Escherichia coli and is derived from the T7 phage RNA polymerase gene. |
|
V55133 | Taq DNA polymerase | 2304873-37-6 | Taq DNA polymerase is a thermostable DNA polymerase that may be utilized in PCR. |
|
V13524 | TAS-102 (Trifluridine/Tipiracil HCl) | 733030-01-8 | TAS-102 (a mixture of Trifluridine and tipiracil hydrochloridein a 1:0.5 molar ratio) is a combination drug under investigation for treating metastatic colorectal cancer. |
|
V1479 | Tegafur (FT-207; NSC 148958) | 17902-23-7 | Tegafur (formerly known as Fluorafur, FT-207, NSC-148958; Uftoral; UFT), a component of tegafur-uracil, is a chemotherapeutic anticancer prodrug of 5-FU (5-Fluorouracil, an anticancer drug) that is commonly used in the treatment of various cancers. |
|
V56558 | Tempo-d18 | 205679-68-1 | Tempo-d18 is the deuterated version of Tempo. |
|
V55199 | Tetrapeptide | 31008-44-3 | Tetrapeptide is an analogue of α-MSH that induces melanin synthesis. |
|
V35205 | Thailanstatin C | 1426953-24-3 | Thailanstatin C is a pre-mRNA splicing inhibitor (IC50= 6.84 μM) and an anti-proliferation agent. |
|
V35203 | Thio-ITP (6-Thioinosine 5′-triphosphate; 6-Mercaptopurine-riboside-5'-triphosphate; 6-Thio-ITP) | 27652-34-2 | Thio-ITP (6-Thioinosine 5′-triphosphate) is a novel and potent inhibitor of RNA polymerase activity. |
|
V5134 | Thymidine (DThyd; NSC 21548) | 50-89-5 | Thymidine (also known as deoxythymidine; other names deoxyribosylthymine, thymine deoxyriboside) is a pyrimidine deoxynucleosideused as a cell synchronizing agent. |
|
V32209 | Tirandamycin A | 34429-70-4 | Tirandamycin A, an antibiotic, is a bacterial RNA polymerase inhibitor. |
|
V2905 | Tirapazamine | 27314-97-2 | Trapazamine (also known as TP, SR-4233; SR259075; Win59075; SR4233) is an experimental adjuvant drug and a DNA-damaging agent that has the potential for the treatment of cervical carcinoma, head and neck cancer. |
|
V35194 | TK216 | 1903783-48-1 | TK216 is an orally available inhibitor of E26 transcription factor (ETS). |
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
