RNA synthesis, which is also called DNA transcription, is a highly selective process.Beyond RNA synthesis, RNA polymerase II transcription plays a more active role in the maturation, monitoring, and export of mRNA to the cytoplasm.
In order to fully repair the DNA after a single-strand break, DNA ligase constructs the final phosphodiester bond using the complementary strand of the double helix as a template.Substrates with RNA strands or mismatched base pairs near the ends of the nicked DNA are discriminated against by DNA ligases. Bleomycin (BLM) is a S-independent radiomimetic agent that damages DNA by creating free radicals that attack the C-4′ position in the deoxyribose backbone. This causes the ribose ring to open and strand breaks to occur.
M-MuLV Reverse Transcriptase (RNase H) and random hexamer primers are used to create first strand cDNA. The next step involves the use of DNA Polymerase I and RNase H to create second strand cDNA. Exonuclease/polymerase activity transforms the remaining overhangs into blunt ends. DNA fragments' 3′ ends are adenylated before being ligated with a NEBNext Adaptor with a hairpin loop structure to get the samples ready for hybridization. The two pathways that BET bromodomain inhibition most commonly affects are cell cycle and DNA replication. The translation of mRNA into proteins is inhibited by cycloheximide.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V56159 | Ribonuclease H (RNase H) | 9050-76-4 | Ribonuclease H is an enzyme that degrades the RNA portion of DNA-RNA hybrids. |
|
V55111 | Ribonuclease T1 (Rnase T1) | 9026-12-4 | Ribonuclease T1 (RNase T1), commonly used in biochemical research. |
|
V1468 | Rifampin (Rifampicin) | 13292-46-1 | Rifampin (Rimactane; Arficin; Arzide; Rifampicin; Rifadin; Rimactane; Rimactan; Tubocin; Archidyn; Benemicin; Doloresum; Eremfat; Fenampicin; Sinerdol), an approved broad spectrum and semisynthetic antibiotic found in Streptomyces mediterranei, is mainly used to treat various bacterial infections such as TB-tuberculosis, leprosy,mycobacterium avium complex, and Legionnaires disease. |
|
V1469 | Rifaximin | 80621-81-4 | Rifaximin (BRN-3584528; L-105SV; Fatroximin; Normix; Rifacol; Rifaxidin; Rifaxin; Ritacol; Rifaximin; RCIFAX, Rifagut; Xifaxan; Zaxine) is an orally bioavailable and semi-synthetic RNA synthesis inhibitor used to treat travelers diarrhea caused by certain bacteria. |
|
V13787 | Rimantadine Hydrochloride | 1501-84-4 | Rimantadine HCl (Flumadine Hydrochloride) is a bioactive oral medication that inhibits the influenza virus and can be used to treat and prevent influenza A fever. |
|
V75896 | RNA polymerase II-IN-1 | 2891451-07-1 | RNA polymerase II-IN-1 (compound 19iv) is an amanitaxin that can inhibit RNA polymerase II (Pol II) with IC50 of 36.66 nM. |
|
V55157 | RNA splicing modulator 1 | 2726461-38-5 | RNA splicing modulator 1 (compound 233) is an RNA splicing modulator with AC50 value <100 nM. |
|
V55155 | RNA splicing modulator 2 | 2726461-41-0 | RNA splicing modulator 2 (compound 256) is an RNA splicing modulator. |
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V55115 | RNA splicing modulator 3 | 2726461-43-2 | RNA splicing modulator 3 (compound 236) is an RNA splicing modulator with AC50 value <100 nM. |
|
V81317 | RNase III | RNase III is a double-stranded RNA (dsRNA)-specific endonuclease produced by Escherichia coli expressing the RNase III gene. | |
|
V81318 | RNaseL-IN-1 | RNase L-IN-1 (compound 17a) is an inhibitor (blocker/antagonist) of RNase L or ribonuclease L. | |
|
V38155 | RP-6685 | 2832047-80-8 | RP-6685 is a novel, orally active inhibitor of DNA polymerase theta (Polθ) with an IC50 of 5.8 nM (PicoGreen assay). |
|
V55122 | rU Phosphoramidite (DMT-2'O-TBDMS-rU phosphoramidite) | 118362-03-1 | rU Phosphoramidite is a phosphoramidite monomer that may be utilized in the preparation /synthesis of oligonucleotides. |
|
V37900 | S-(N-PhenethylthiocarbaMoyl)-L-cysteine (PEITC-Cys) | 53330-02-2 | S-(N-PhenethylthiocarbaMoyl)-L-cysteine (PEITC-Cys)is an antileukemia agent that also has anticarcinogenic properties. |
|
V35273 | S-MGB-234 | 1970223-53-0 | S-MGB-234 is a minor groove adhesive for African animal trypanosomiasis (AAT). |
|
V1434 | SCR7 | 1533426-72-0 | SCR7 (SCR-7; SCR 7) is a potent and selective inhibitor of DNA Ligase IV with potential anticancer activity. |
|
V1477 | Sofosbuvir (PSI-7977; GS-7977) | 1190307-88-0 | Sofosbuvir (also known as PSI-7977, GS-7977; PSI7977; GS7977; Vosevi; Hepcinat; Hepcvir; Resof; Sovaldi and Virunon), ablockbuster anti-HCV drug, is an HCV NS5B polymerase inhibitor that has been approved for the treatment of chronic hepatitis C virus (HCV) infections. |
|
V15074 | Sorivudine | 77181-69-2 | Sorivudine (BV-araU; Bravavir; ARYS-01; SQ-32756; BVAU; JA-001; YN-72; DRU-0136) is a novel and potent DNA polymerase inhibitor with the potential to be used for the treatment of herpes zoster (shingles). |
|
V75892 | SP-471P | 2768011-36-3 | SP-471P is a potent Dengo virus (DENV) protease inhibitor (antagonist) with EC50s of 5.9 μM, 1.4 μM, 5.1 μM and 1.7 μM for DENV1, DENV2, DENV3 and DENV4 respectively, and CC50 is greater than 100 μM. |
|
V55192 | Spacer phosphoramidite C3 | 110894-23-0 | Spacer phosphoramidite C3 is a phosphoramidite monomer that may be utilized in the preparation /synthesis of oligonucleotides. |
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