RNA synthesis, which is also called DNA transcription, is a highly selective process.Beyond RNA synthesis, RNA polymerase II transcription plays a more active role in the maturation, monitoring, and export of mRNA to the cytoplasm.
In order to fully repair the DNA after a single-strand break, DNA ligase constructs the final phosphodiester bond using the complementary strand of the double helix as a template.Substrates with RNA strands or mismatched base pairs near the ends of the nicked DNA are discriminated against by DNA ligases. Bleomycin (BLM) is a S-independent radiomimetic agent that damages DNA by creating free radicals that attack the C-4′ position in the deoxyribose backbone. This causes the ribose ring to open and strand breaks to occur.
M-MuLV Reverse Transcriptase (RNase H) and random hexamer primers are used to create first strand cDNA. The next step involves the use of DNA Polymerase I and RNase H to create second strand cDNA. Exonuclease/polymerase activity transforms the remaining overhangs into blunt ends. DNA fragments' 3′ ends are adenylated before being ligated with a NEBNext Adaptor with a hairpin loop structure to get the samples ready for hybridization. The two pathways that BET bromodomain inhibition most commonly affects are cell cycle and DNA replication. The translation of mRNA into proteins is inhibited by cycloheximide.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V53143 | NSC639828 | 134742-26-0 | NSC639828 is a selective inhibitor of DNA polymerase α with an IC50 of 70 μM. NSC639828 exhibits strong antitumor properties. |
|
V85648 | NSC727447 | 40106-12-5 | |
|
V55131 | Nuclease S1 | 37288-25-8 | Nuclease S1 is an endonuclease that specifically breaks down RNA and single-stranded DNA (ssDNA). |
|
V0057 | Oxaliplatin (Eloxatin; L-OHP; JM-83; RP-54780; SR-96669) | 61825-94-3 | Oxaliplatin (Eloxatin; L-OHP; JM83; RP54780; SR96669),an anticancer drug used for treating colorectal cancer,is an organoplatinum complex (1,2-diaminocyclohexane (DACH) and with an oxalate ligand), acnting by inhibiting DNA synthesis by forming DNA adducts in RT4, TCCSUP, A2780, HT-29, U-373MG, U-87MG, SK-MEL-2, and HT-144 cells. |
|
V56311 | Oxolinic acid-d5 (oxolinic acid d5) | 1189890-98-9 | Oxolinic acid-d5 is the deuterated product of Oxolinic acid. |
|
V0846 | Pemetrexed disodium | 150399-23-8 | Pemetrexed disodium (formerly HSDB-7316; LY-231514; Alimta), the disodium salt ofPemetrexed, is a marketed anticancer drug of the antifolate and antimetabolite class. |
|
V2481 | pentixather | Desription: Pentixather, structurally similar to PentixaFor, is an iodinated form of PentixaFor which is a ligand/intermediate used for the preparation of gallium Ga 68-pentixafor. | |
|
V19201 | PFM01 | 1558598-41-6 | PFM01 is a nuclease-specific MRE11 inhibitor. |
|
V81142 | PINT-87aa | PINT-87aa is an 87-amino acid (AA) peptide encoded by the circular form of the long intergenic nonprotein-coding RNA p53-induced transcript (LINC-PINT). | |
|
V81143 | PINT-87aa TFA | PINT-87aa TFA is an 87-amino acid (AA) peptide encoded by the circular form of the long intergenic non-protein-coding RNA p53-induced transcript (LINC-PINT). | |
|
V22437 | Plitidepsin | 137219-37-5 | Plitidepsin (dehydrodemnin B; aplidine; Aplidin) is a naturally occurring cyclic depsipeptide extracted from the marine tunicate Aplidium albicans with a broad spectrum of anticancer activities. |
|
V75900 | Pol I-IN-1 | 2765318-69-0 | Pol I-IN-1 is a potent inhibitor of RNA polymerase I (Pol I) with IC50 of 0.21 µM for the large Pol I catalytic subunit RPA194. |
|
V53287 | POL1-IN-1 | 1822358-25-7 | POL1-IN-1 is a RNA polymerase 1 POL1 (also known as Pol I) inhibitor with an IC50 value of less than 0.5 uM. |
|
V55159 | Poly(A) polymerase | 9026-30-6 | Poly(A) polymerase catalyzes the addition of a polyadenosine tail, or ATP, to the 3' end of RNA in the form of AMP. |
|
V75901 | Polynucleotide kinase | 37211-65-7 | Polynucleotide Kinase is a DNA repair enzyme. |
|
V81203 | Procaine-d4 hydrochloride (procaine d4 hydrochloride) | Procaine-d4 ( HCl) is the deuterated form of Procaine HCl. | |
|
V1446 | Procarbazine HCl (NSC-77213) | 366-70-1 | Procarbazine HCl (formerly NSC77213; Ro4-6467;CB-400-497; PCB; PCZ; Matulane; Natulanar), the hydrochloride salt form of procarbazine, is ananticancer chemotherapeutic medication approved for the treatment of Hodgkins lymphoma and certain brain cancers. |
|
V55119 | Prunasin | 99-18-3 | Prunasin is an inhibitor (blocker/antagonist) of DNA Polymerase β. |
|
V1433 | Pyridostatin Trifluoroacetate (RR82) | 1472611-44-1 | Pyridostatin Trifluoroacetate(RR82; RR 82; RR-82; PDS; Pyridostatin TFA), the Trifluoroacetate(TFA) salt of Pyridostatin, is a G-quadruplexe stabilizer with potential antineoplastic activity. |
|
V80291 | qsl-304 | qsl-304 is a DNA gyrase B inhibitor. |
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