The enzyme cyclooxygenase (COX), also referred to as prostaglandin-endoperoxide synthase (PTGS), is in charge of producing the vital biological mediators known as prostanoids, such as prostaglandins, prostacyclin, and thromboxane. Pain and inflammation symptoms can be reduced by pharmacologically inhibiting COX. The general public has had access to cyclooxygenase activity-inhibiting medications for about 100 years, including aspirin. The two cyclooxygenase isoforms, COX-1 and COX-2, have been identified. The COX-1 enzyme is frequently produced constitutively (i.e., in the gastric mucosa), whereas the COX-2 enzyme is induced (i.e., at sites of inflammation). Aspirin and ibuprofen are examples of NSAIDs that work by inhibiting COX to produce their desired effects. The non-steroidal anti-inflammatory drugs (NSAIDs) are the primary COX inhibitors.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V38709 | Diclofenac potassium | 15307-81-0 | Diclofenac potassium (Voltarol; Voltaren), the potassium salt of diclofenac, is a nonsteroidal anti-inflammatory drug (NSAID) that is able to reduce inflammation and to be used as an analgesic reducing pain in certain conditions. |
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V79114 | Diclofenac-13C6 sodium heminonahydrate (Diclofenac sodium 13C6 (1/2 water)) | Diclofenac-13C6 (sodium heminonahydrate) is a 13C (carbon 13)-labeled Diclofenac (Sodium). | |
|
V4369 | DIFLUNISAL | 22494-42-4 | Diflunisal (also known as MK-647; trade name Dolobid) is a novel and potent salicylate derivative with nonsteroidal anti-inflammatory and uricosuric properties, it is used alone as an analgesic and in rheumatoid arthritis patients. |
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V10613 | Esflurbiprofen | 51543-39-6 | Esflurbiprofen (BTS-24332; TT 063; BTS24332;TT063; SFPP;BTS 24332; TT-063; Trade name: Loqoa), the S-enantiomrer or S-isomer of Flurbiprofen, is a potent cyclooxygenase (COX) inhibitor and anonsteroidal anti-inflammatory drugs (NSAIDs) with antipyretic and analgesic activity. |
|
V4024 | Firocoxib | 189954-96-9 | Firocoxib (formerly ML-1785713; ML1785713) is a novel, potent and selective cyclooxygenase (COX)-2 inhibitor (IC50 = 0.13 uM) with 58-fold sensitivity for COX2 over COX1. |
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V21050 | FK3311 | 116686-15-8 | FK3311 is a cyclooxygenase-2 (COX-2) inhibitor. |
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V1968 | Flufenamic acid (CI-440; CN-27554) | 530-78-9 | Flufenamic Acid (CI-440; CN-27554) is an anti-inflammatory agent of the NSAIDs (non-steroidal anti-inflammatory agent) class. |
|
V4881 | flurbiprofen | 5104-49-4 | Flurbiprofen, a phenylalkanoic acid derivative, belongs to the class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs) with antipyretic and analgesic activity. |
|
V8326 | FR-122047 HCl | 130717-51-0 | FR-122047 HCl (FR 122047; FR122047), the hydrochloride salt of FR-122047, is a novel, potent and selective cyclooxygenase-1 (COX-1) inhibitor with potential anticancer activities. |
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V17597 | Iguratimod | 123663-49-0 | Iguratimod (T614; T-614) is a 4H-1-benzopyran-basedantirheumatic agent acting as anovel and potentnhibitor of COX-2 (IC50 = 20 μM) with no effect on COX-1. |
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V30554 | Isoorientin | 4261-42-1 | Isoorientin is a potent COX-2 inhibitor (antagonist) with IC50 of 39 μM. |
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V21289 | Ketorolac tromethamine (RS37619 tromethamine) | 74103-07-4 | Ketorolac tromethamine(RS37619tromethamine), potent NSAID (non-steroidal anti-inflammatory drug), is a potent and non-selective COX inhibitor of COX-1 and COX-2 with IC50 of 1.23 μM and 3.50 μM, respectively. |
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V13275 | Macelignan | 107534-93-0 | Macelignan ((+)-Anwulignan; Anwuligan) is a bioactive lignan extracted from nutmeg. |
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V25071 | Mavacoxib (PHA-739521) | 170569-88-7 | Mavacoxib (PHA-739521),a long-acting non-steroidal anti-inflammatory drug (NSAID), is aselective, orally active and long-actingcyclooxygenase-2 (COX-2)inhibitor used to treat pain and inflammation associated with degenerative joint disease in dogs. |
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V5230 | Metyrosine (Metirosine) | 672-87-7 | Metirosine (α-Methyltyrosine, Metyrosine, AMPT) is an antihypertensive drug that acts by inhibiting the enzyme tyrosine hydroxylase and, therefore, catecholamine synthesis, which, as a consequence, depletes the levels of the catecholamines dopamine, adrenaline and noradrenaline in the body. |
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V2740 | Mofezolac | 78967-07-4 | Mofezolac (formerly known as N-22; trade name in Japan: Disopain) is a highly selective COX-1 (cyclooxygenase-1) inhibitor with COXs selectivity index>6000. |
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V10807 | Naproxen [(S)-Naproxen)] | 22204-53-1 | Naproxen (also known as (S)-Naproxen))is anon-steroidal anti-inflammatory drug (NSAID) which is a nonselective COX inhibitor for COX-1 and COX-2 with IC50 of 8.7 μM and 5.2 μM, respectively. |
|
V12164 | Nitroaspirin | 175033-36-0 | Nitroaspirin (NOASA;NCX4016; mNOASA) is a novel and potent nitric oxide (NO) donor with anticancer, antithrombotic and anti-platelet activities. |
|
V2703 | NS-398 | 123653-11-2 | NS-398 [also called NS 398,N-(2-cyclohexyloxy-4-nitrophenyl)methane sulfonamide]is a novel, highly potentandselective inhibitor of cyclooxygenase-2 (COX-2) that is used as a non-steroidal an-inflammatory agent with analgesic and antipyretic effects. |
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V76670 | Oxaprozin-d4 (Oxaprozin D4; Wy-21743-d4) | Oxaprozin-d4 is the deuterated form of Oxaprozin. |
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