The enzyme cyclooxygenase (COX), also referred to as prostaglandin-endoperoxide synthase (PTGS), is in charge of producing the vital biological mediators known as prostanoids, such as prostaglandins, prostacyclin, and thromboxane. Pain and inflammation symptoms can be reduced by pharmacologically inhibiting COX. The general public has had access to cyclooxygenase activity-inhibiting medications for about 100 years, including aspirin. The two cyclooxygenase isoforms, COX-1 and COX-2, have been identified. The COX-1 enzyme is frequently produced constitutively (i.e., in the gastric mucosa), whereas the COX-2 enzyme is induced (i.e., at sites of inflammation). Aspirin and ibuprofen are examples of NSAIDs that work by inhibiting COX to produce their desired effects. The non-steroidal anti-inflammatory drugs (NSAIDs) are the primary COX inhibitors.
Structure | Cat No. | Product Name | CAS No. | Product Description |
---|---|---|---|---|
V77404 | (+/-)-Catechin Gallate-13C3 (Catechin Gallate 13C3) | (+/-)-Catechin Gallate-13C3 is a 13C (carbon 13)-labeled (-)-Catechin gallate. | ||
V77593 | 2-O-Sinapoyl makisterone A | 2-O-Sinapoyl makisterone A (compound 2) is a sinapic acid-ecdysterone hybrid and is a selective inhibitor of COX-2. | ||
V33020 | Anemarsaponin B | 139051-27-7 | Anemarsaponin B is a naturally occuring steroidal saponin extracted from the rhizomes of A. | |
V78015 | Anti-inflammatory agent 52 | Anti-inflammatory agent 52 (compound 7j) is an orally bioavailable, potent and specific COX-2 inhibitor. | ||
V78016 | Anti-inflammatory agent 53 | Anti-inflammatory agent 53 (compound 7c) is an orally bioavailable, potent and specific COX-2 inhibitor. | ||
V2894 | ATB-346 | 1226895-20-0 | ATB-346, a structural analog of naproxen (one of the NSAIDs-Nonsteroidal anti-inflammatory drugs), is anti-inflammatory agent. | |
V31157 | Byakangelicol | 26091-79-2 | Byakangelicol, a leukotriol extracted from Angelica dahurica, inhibits interleukin-1β (IL-1β)-induced prostate cancer in A549 cells by inhibiting the expression and activity of cyclooxygenase-2 (COX-2). | |
V2102 | CAY10404 | 340267-36-9 | CAY10404 is novel, and highly selective inhibitor of COX-2 which has been reported to date, with a selectivity index (SI; SI = IC50COX-1/IC50COX-2) of >500,000. | |
V31341 | Chebulagic acid | 23094-71-5 | Chebulagic acid is a naturally occurring COX-LOX dual inhibitorisolated from the Terminalia chebula Retz. | |
V78861 | COX-1/2-IN-4 | COX-1/2-IN-4 is a COX inhibitor (antagonist) with IC50s of 0.239 μM and 0.191 μM for COX-1 enzyme and COX-2 enzyme, respectively. | ||
V79761 | COX-1/2-IN-5 | COX-1/2-IN-5 (compound 2a) is a dual (bifunctional) inhibitor of COX1/2 (IC50=2.650 μM, 0.958 μM) with anti-cancer activity. | ||
V80073 | COX-2-IN-31 | COX-2-IN-31 (compound 7b) is an orally bioactive COX/5-LOX dual (bifunctional) inhibitor (antagonist) with IC50 of 60 nM (COX-2) and 0.9 μM (5-LOX). | ||
V78864 | COX-2-IN-33 | COX-2-IN-33 (compound 5f) is a COX-2 inhibitor (IC50=45.5 nM) and a potential anti-inflammatory agent. | ||
V79472 | COX-2-IN-35 | COX-2-IN-35 (compound 7) is a selective COX-2 inhibitor (antagonist) with IC50 of 4.37 nM. | ||
V78603 | COX-2/15-LOX-IN-2 | COX-2/15-LOX-IN-2 is a potent dual COX-2 and 15-LOX inhibitor (antagonist) with IC50s of 0.065 μM and 1.86 μM, respectively. | ||
V78897 | COX-2/15-LOX-IN-3 | COX-2/15-LOX-IN-3 (compound 5k) is a dual (bifunctional) inhibitor of COX-2/15-LOX with IC50s of 0.075 μM and 1.97 μM respectively. | ||
V79276 | COX-2/15-LOX-IN-4 | COX-2/15-LOX-IN-4 (compound 5i) is a dual (bifunctional) inhibitor of COX-2/15-LOX with IC50s of 0.075 μM and 1.97 μM, respectively. | ||
V8259 | Deracoxib (SC 046; SC 46; SC 59046) | 169590-41-4 | Deracoxib (SC-046; SC-46; SC-59046) is a novel and potent NSAID and COX-2 inhibitor used to treat osteoarthritis. | |
V40446 | Desmethyl Celecoxib | 170569-87-6 | Desmethyl Celecoxib (PTPBS) is an demethylated metabolite of Celecoxib (SC58635; YM-177;SC-58635; YM 177; Celebrex; Xilebao) which is cyclooxygenase-2 (COX-2) inhibitor approved asananti-inflammatory agent of the NSAID class. | |
V19799 | Diclofenac | 15307-86-5 | Diclofenac (formerly GP-45840; Voltarol; Voltaren) is a potent nonsteroidal anti-inflammatory drug (NSAID), acting as a non-selective COX inhibitor with IC50 of 0.5 μg/ml and 0.5 μg/ml for COX-1 and -2 in intact cells, respectively, used to relieve pain and reduce swelling in flammation. |