Drug-Linker Conjugates for ADC

Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD
GPCR & G Protein

5-HT Receptor Adenosine Receptor Adenylate Cyclase Adrenergic Receptor Angiotensin Receptor APJ Bombesin Receptor Bradykinin Receptor cAMP Cannabinoid Receptor CaSR CCK receptor CCR CGRP Receptor CRFR CXCR Dopamine Receptor EBI2 Endothelin Receptor Formyl Peptide Receptor Free Fatty Acid Receptor G protein-coupled Bile Acid Receptor GCGR GHSR GLP Receptor Glucagon Receptor GnRH Receptor GPCR19 GPR GPR109A Guanylate Cyclase Hedgehog(Smoothened) ROCK Histamine Receptor ICMT Leukotriene Receptor LPA Receptor LPL Receptor LTR mAChR Melanocortin Receptor Melatonin Receptor mGluR Motilin Receptor MRGPR MT Receptor Neurokinin Receptor Neuropeptide Y Receptor Neurotensin Receptor NPY receptor Opioid Receptor OX Receptor Oxytocin Receptor P2Y Receptor PAFR PAR PKD PKG Prostaglandin Receptor Ras RGS Protein S1P Receptor SGLT Sigma Receptor Somatostatin Receptor TAAR TSH Receptor Urotensin Receptor Vasopressin Receptor

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Drug-Linker Conjugates for ADC

The components of drug-linker conjugates for antibody drug conjugates (ADCs) are a cytotoxic drug that is active and a suitable linker. These conjugates can be used to create ADCs, which are highly selective and cytotoxic agents that are targeted for cancer cells after being joined to a monoclonal antibody.

The drug units in drug-linker conjugates are tubulin inhibitors and DNA damaging agents that have antitumor activity (i.e., ADC cytotoxins or payloads). Auristatins and Maytansinoids are the most widely used tubulin inhibitors, while Duocarmycins, Pyrrolobenzodiazepines, Camptothecines, and Daunorubicins/Doxorubicines are the most frequently used DNA damaging agents in ADCs. Additionally, a variety of conventional cytotoxic agents can be used in ADCs.

Cleavable and noncleavable ADC linkers are the two categories into which the majority of those currently undergoing clinical evaluation fall. Noncleavable linkers necessitate proteolytic degradation of the antibody component of the ADC in order to release the cytotoxic molecule, whereas cleavable linkers depend on cellular processes to release the toxin.

Drug-Linker Conjugates for ADC related products

Cat No.	Product Name	CAS No.	Product Description
V54768	MC-DOXHZN ((E/Z)-Aldoxorubicin; Doxorubicin(6-maleimidocaproyl)hydrazone)	151038-96-9	MC-DOXHZN ((E/Z)-Aldoxorubicin) is the albumin-bound precursor of Doxorubicin, a DNA topoisomerase II inhibitor, and is acid-sensitive.
V54798	MC-EVCit-PAB-MMAE	2873452-49-2	MC-EVCit-PAB-MMAE (Linker-Payload 11) is an ADC .
V54799	MC-GGFG-(7ethanol-10NH2-11F-Camptothecin)	2873460-72-9	MC-GGFG-(7ethanol-10NH2-11F-Camptothecin) (compound 141) is a drug-linker conjugate for ADC, which is composed of 7ethanol-10NH2-11F-Camptothecin and protease cleavable MC-GGFG.
V54761	MC-GGFG-AM-(10Me-11F-Camptothecin)	2873460-70-7	MC-GGFG-AM-(10Me-11F-Camptothecin) is a Linker-Payload conjugate used in the synthesis/preparation of ZW251.
V54758	MC-Gly-Gly-Phe-Gly-(R)-Cyclopropane-Exatecan	2414254-51-4	MC-Gly-Gly-Phe-Gly-(R)-Cyclopropane-Exatecan is part of a drug-linker conjugate for ADC, containing Exatecan .
V54785	MC-Gly-Gly-Phe-Gly-(S)-Cyclopropane-Exatecan	2414254-52-5	MC-Gly-Gly-Phe-Gly-(R)-Cyclopropane-Exatecan is a part of the antibody conjugate active molecule (drug-linker conjugate for ADC)such as Exatecan .
V52928	MC-SN38	1473403-87-0	MC-SN38 is an active molecular conjugate consisting of the potent microtubule-destroying agent SN38 and a non-cleavable (non-degradable) MC linker.
V76781	Mc-Val-Cit-PAB-Gefitinib chloride		Mc-Val-Cit-PAB-Gefitinib chloride is an ADC drug-linker conjugate (drug-linker conjugates for ADC).
V51227	MC-Val-Cit-PAB-MMAF (Vc-MMAF)	863971-17-9	drug-linker conjugate
V54754	MC-VC-PAB-Cyclohexanediamine-Thailanstatin A	1609108-96-4	MC-VC-PAB-Cyclohexanediamine-Thailanstatin A is a splicing statin analog and a drug-linker conjugate constituting ADC, consisting of ADC cytotoxic Thailanstatin A and consisting of cleaved ADC linker (MC-vc-PAB).
V80722	MC-VC-PAB-MMAD		MC-VC-PAB-MMAD is part of an antibody-active molecule conjugate, which is connected by the microtubule inhibitor MMAD and the degradable ADC linker MC-VC-PAB.
V52449	Mc-VC-PAB-SN38	1801838-28-7	Mc-VC-PAB-SN38 is made up of cleavable ADC (Antibody-drug conjugate) linker (Mc-VC-PAB) and SN38, a DNA topoisomerase I inhibitor.
V54791	MC-VC-PAB-Tubulysin M	1639939-56-2	MC-vc-PAB-Tubulysin M is made up of a cleavable ADC (Antibody-drug conjugate) linker (MC-vc-PAB) and a cytotoxic molecule, the tubulin inhibitor Tubulysin M .
V54780	MC-VC-PABC-C6-alpha-Amanitin	2922514-69-8	MC-VC-PABC-C6-alpha-Amanitin is an antibody active molecular conjugate (ADC) consisting of the anti-cancer toxin alpha-Amanitin and the monoclonal antibody (mAb) MC-VC-PABC-C6.
V53075	MCC-DM1	1100692-14-5	MCC-DM1 is a bioactive molecule-linker conjugate used for ADC synthesis, like used for the synthesis of Anti-CD22-MCC-DM1.
V51087	Mipsagargin (G-202)	1245732-48-2	thapsigargin-based PDC targeting PSMA
V51232	Modified MMAF-C5-COOH	1404071-65-3	Modified MMAF-C5-COOH is a drug-linker conjugate for ADC.
V54789	mp-dLAE-PABC-MMAE	2625616-44-4	mp-dLAE-PABC-MMAE is part of the active molecule for antibody conjugation.
V54759	MP-PEG4-Val-Lys-Gly-7-MAD-MDCPT	2378428-19-2	MP-PEG4-Val-Lys-Gly-7-MAD-MDCPT, a camptothecin-linker compound, is part of the drug-linker conjugate for ADC.
V80833	Mp-polymer ester		Mp-polymer ester is a non-cleavable (non-degradable) ADC linker used to synthesize Antibody-drug conjugates (ADCs).