Drug-Linker Conjugates for ADC

Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD
GPCR & G Protein

5-HT Receptor Adenosine Receptor Adenylate Cyclase Adrenergic Receptor Angiotensin Receptor APJ Bombesin Receptor Bradykinin Receptor cAMP Cannabinoid Receptor CaSR CCK receptor CCR CGRP Receptor CRFR CXCR Dopamine Receptor EBI2 Endothelin Receptor Formyl Peptide Receptor Free Fatty Acid Receptor G protein-coupled Bile Acid Receptor GCGR GHSR GLP Receptor Glucagon Receptor GnRH Receptor GPCR19 GPR GPR109A Guanylate Cyclase Hedgehog(Smoothened) ROCK Histamine Receptor ICMT Leukotriene Receptor LPA Receptor LPL Receptor LTR mAChR Melanocortin Receptor Melatonin Receptor mGluR Motilin Receptor MRGPR MT Receptor Neurokinin Receptor Neuropeptide Y Receptor Neurotensin Receptor NPY receptor Opioid Receptor OX Receptor Oxytocin Receptor P2Y Receptor PAFR PAR PKD PKG Prostaglandin Receptor Ras RGS Protein S1P Receptor SGLT Sigma Receptor Somatostatin Receptor TAAR TSH Receptor Urotensin Receptor Vasopressin Receptor

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Drug-Linker Conjugates for ADC

The components of drug-linker conjugates for antibody drug conjugates (ADCs) are a cytotoxic drug that is active and a suitable linker. These conjugates can be used to create ADCs, which are highly selective and cytotoxic agents that are targeted for cancer cells after being joined to a monoclonal antibody.

The drug units in drug-linker conjugates are tubulin inhibitors and DNA damaging agents that have antitumor activity (i.e., ADC cytotoxins or payloads). Auristatins and Maytansinoids are the most widely used tubulin inhibitors, while Duocarmycins, Pyrrolobenzodiazepines, Camptothecines, and Daunorubicins/Doxorubicines are the most frequently used DNA damaging agents in ADCs. Additionally, a variety of conventional cytotoxic agents can be used in ADCs.

Cleavable and noncleavable ADC linkers are the two categories into which the majority of those currently undergoing clinical evaluation fall. Noncleavable linkers necessitate proteolytic degradation of the antibody component of the ADC in order to release the cytotoxic molecule, whereas cleavable linkers depend on cellular processes to release the toxin.

Drug-Linker Conjugates for ADC related products

Cat No.	Product Name	CAS No.	Product Description
V53302	Mal-PEG4-VA-PBD	1342820-68-1	Mal-PEG4-VA-PBD is an antibody-conjugated active molecule, which is composed of the anti-tumor antibiotic Pyrrolobenzodiazepine (PBD) and Mal-PEG4-VA.
V51214	Mal-PEG4-VC-PAB-DMEA-PNU-159682	2259318-52-8	drug-linker conjugate for ADC
V54767	Mal-PEG4-VC-PAB-DMEA-Seco-Duocarmycin SA	2259318-49-3	Mal-PEG4-VC-PAB-DMEA-Seco-Duocarmycin SA is an antibody-conjugated active molecule, which is composed of the anti-tumor antibiotic Duocarmycin SA and Mal-PEG4-VC-PAB-DMEA-Seco.
V53293	Mal-PEG8-amide-Val-Ala-(4-NH2)-Exatecan	2495742-34-0	Mal-PEG8-amide-Val-Ala-(4-NH2)-Exatecan is the conjugate used in the synthesis/preparation of ADC.
V53107	Mal-PEG8-Phe-Lys-PAB-Exatecan	2679821-44-2	Mal-PEG8-Phe-Lys-PAB-Exatecan (compound 15) is a part of the antibody conjugate active molecule ADC (drug-linker conjugate for ADC), consisting of a degradable linker Mal-PEG8-Phe-Lys-PAB and toxin consisting of the molecule Exatecan .
V76792	Mal-PEG8-Phe-Lys-PAB-Exatecan TFA		Mal-PEG8-Phe-Lys-PAB-Exatecan TFA is a bioactive molecule linker conjugate of antibody conjugated active molecule (ADC) (drug-linker conjugate for ADC), consisting of degradable linker Mal-PEG8-Phe- Lys-PAB is made up of the toxin molecule Exatecan.
V80671	Mal-PEG8-Val-Ala-PAB-SB-743921		Mal-PEG8-Val-Ala-PAB-SB-743921 (Compound D7) is an ADC drug-linker conjugate (Drug-Linker Conjugates for ADC).
V76790	Mal-PEG8-Val-Cit-PAB-MMAF		Mal-PEG8-Val-Cit-PAB-MMAF is part of the antibody-linker conjugate for ADC.
V51216	Mal-Phe-C4-VC-PAB-DMEA-PNU-159682	2259318-54-0	drug-linker conjugate for ADC
V54757	Mal-Phe-C4-VC-PAB-MMAE	2259318-51-7	Mal-Phe-C4-VC-PAB-MMAE is made from MMAE coupled to Mal-Phe-C4-VC-PAB linker.
V35250	Mal-VC-PAB-(N-Me-amide-C3)-ADU-S100 triethylamine	2249935-19-9	Mal-VC-PAB-(N-Me-amide-C3)-ADU-S100 triethylamine is an immunostimulatory antibody conjugate (ISAC) containing an anti-human epidermal growth factor receptor 2 (HER2) antibody, STING agonist agent (ADU-S100) and a linker.
V54775	Mal-VC-PAB-ABAEP-Azonafide	2259318-48-2	Mal-VC-PAB-ABAEP-Azonafide is part of an antibody-drug-conjugate/ADC with anti-cancer activity.
V53106	Mal-VC-PAB-DM1	1464051-44-2	Mal-VC-PAB-DM1 is a part of the antibody-drug-conjugates/ADCs, which is connected by the microtubule-destroying agent DM1 and the ADC linker Mal-VC-PAB.
V52442	Mal-VC-PAB-PNP-CDN-A	2640880-35-7	Mal-VC-PAB-PNP-CDN-A ADC molecule active molecule and linker conjugate.
V54795	MB-VC-MGBA	932744-62-2	MB-VC-MGBA is part of the active antibody coupling molecule, which is connected by the DNA alkylating agent MGBA and the ADC linker MB-VC.
V54779	MC-AAA-NHCH2OCH2COO-7-aminomethyl-10-methyl-11-fluoro camptothecin	2414594-29-7	MC-AAA-NHCH2OCH2COO-7-aminomethyl-10-methyl-11-fluoro camptothecin (compound 21a) is a camptothecin payload that can be combined with monoclonal antibodies (mAb) to synthesize camptothecin ADC molecules.
V53294	MC-betaglucuronide-MMAE-1	1703778-92-0	MC-betaglucuronide-MMAE-1 is part of an antibody-active molecule conjugate consisting of the tubulin polymerization inhibitor MMAE and the degradable ADC linker MC-betaglucuronide.
V54792	MC-betaglucuronide-MMAE-2	1703778-81-7	MC-betaglucuronide-MMAE-2 is part of an antibody-active molecule conjugate consisting of the tubulin polymerization inhibitor MMAE and the degradable ADC linker MC-betaglucuronide.
V53245	Mc-Dexamethasone	1618096-56-2	Mc-Dexamethasone is the active molecular linker conjugate of ADC.
V53147	MC-DM1	1375089-56-7	MC-DM1 is made up of linker MC and toxic molecule DM1, and may be utilized to prepare antibody-drug-conjugates/ADCss.