Drug-Linker Conjugates for ADC

Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD
GPCR & G Protein

5-HT Receptor Adenosine Receptor Adenylate Cyclase Adrenergic Receptor Angiotensin Receptor APJ Bombesin Receptor Bradykinin Receptor cAMP Cannabinoid Receptor CaSR CCK receptor CCR CGRP Receptor CRFR CXCR Dopamine Receptor EBI2 Endothelin Receptor Formyl Peptide Receptor Free Fatty Acid Receptor G protein-coupled Bile Acid Receptor GCGR GHSR GLP Receptor Glucagon Receptor GnRH Receptor GPCR19 GPR GPR109A Guanylate Cyclase Hedgehog(Smoothened) ROCK Histamine Receptor ICMT Leukotriene Receptor LPA Receptor LPL Receptor LTR mAChR Melanocortin Receptor Melatonin Receptor mGluR Motilin Receptor MRGPR MT Receptor Neurokinin Receptor Neuropeptide Y Receptor Neurotensin Receptor NPY receptor Opioid Receptor OX Receptor Oxytocin Receptor P2Y Receptor PAFR PAR PKD PKG Prostaglandin Receptor Ras RGS Protein S1P Receptor SGLT Sigma Receptor Somatostatin Receptor TAAR TSH Receptor Urotensin Receptor Vasopressin Receptor

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Drug-Linker Conjugates for ADC

The components of drug-linker conjugates for antibody drug conjugates (ADCs) are a cytotoxic drug that is active and a suitable linker. These conjugates can be used to create ADCs, which are highly selective and cytotoxic agents that are targeted for cancer cells after being joined to a monoclonal antibody.

The drug units in drug-linker conjugates are tubulin inhibitors and DNA damaging agents that have antitumor activity (i.e., ADC cytotoxins or payloads). Auristatins and Maytansinoids are the most widely used tubulin inhibitors, while Duocarmycins, Pyrrolobenzodiazepines, Camptothecines, and Daunorubicins/Doxorubicines are the most frequently used DNA damaging agents in ADCs. Additionally, a variety of conventional cytotoxic agents can be used in ADCs.

Cleavable and noncleavable ADC linkers are the two categories into which the majority of those currently undergoing clinical evaluation fall. Noncleavable linkers necessitate proteolytic degradation of the antibody component of the ADC in order to release the cytotoxic molecule, whereas cleavable linkers depend on cellular processes to release the toxin.

Drug-Linker Conjugates for ADC related products

Cat No.	Product Name	CAS No.	Product Description
V54796	Fmoc-VAP-MMAE	1912408-91-3	Fmoc-VAP-MMAE is an ADC drug-linker conjugate.
V85444	G3-VC-PAB-DMEA-Duocarmycin DM	2415664-00-3
V53016	GGFG-amide-glycol-amide-Exatecan	2866301-18-8	GGFG-amide-glycol-amide-Exatecan (Intermediate 2) is an Exatecan analogue that may be utilized in the preparation /synthesis of antibody drug conjugates (ADCs).
V53401	GGFG-Eribulin	2841688-66-0	GGFG-Eribulin (Compound GGFG) is an ADC-Drug-Linker Conjugates for ADC.
V79577	GGGDTDTC-Mc-vc-PAB-MMAE		GGGDTDTC-Mc-vc-PAB-MMAE is a drug-linker conjugate of ADC containing the tubulin inhibitor Monomethyl auristatin E (MMAE).
V53073	Glucocorticoid receptor agonist-1 Ala-Ala-Mal	2166376-51-6	Glucocorticoid receptor agonist-1 Ala-Ala-Mal (compound 88) is a glucocorticoid and a glucocorticoid receptor agonist.
V53117	Glucocorticoid receptor agonist-1 phosphate Ala-Ala-Br	2345733-40-4	Glucocorticoid receptor agonist-1 phosphate Ala-Ala-Br is a drug-linker conjugates for ADC and could be utilized as a reaction reagent for the synthesis of anti-CD40 antibody active molecular conjugates (ADCs).
V53387	Glucocorticoid receptor agonist-1 phosphate Ala-Ala-Mal	2345732-89-8	Glucocorticoid receptor agonist-1 phosphate Ala-Ala-Mal is a glucocorticoid receptor agonist.
V85885	Glucocorticoid receptor agonist-1 phosphate Gly-Glu-Mal	2345732-83-2
V54764	Glucocorticoid receptor agonist-2 Ala-Ala-Mal	2166376-64-1	Glucocorticoid receptor agonist-2 Ala-Ala-Mal (compound 79) may be utilized to prepare anti-inflammatory ADC molecules.
V85441	Glucocorticoid receptor agonist-3 Ala-Ala-Mal	3014393-35-9
V85760	Glucocorticoid receptor agonist-4 Ala-Ala-Mal	3014393-37-1
V54781	Gly-Mal-Gly-Gly-Phe-Gly-amide-methylcyclopropane-Exatecan	2766786-76-7	Gly-Mal-Gly-Gly-Phe-Gly-amide-methylcyclopropane-Exatecan can be used for the synthesis of ADC.
V52440	Gly3-VC-PAB-MMAE	2684216-48-4	Gly3-VC-PAB-MMAE is made up of cleavable ADC (Antibody-drug conjugate) linker (Gly3-VC-PAB) and MMAE, which is an effective microtubule (tubulin) inhibitor.
V54770	HS-(CH2)3CO-L-Ala-D-Ala-L-Ala-NH-CH2-S-(CH2)5-CO-DM	2243689-64-5	HS-(CH2)3CO-L-Ala-D-Ala-L-Ala-NH-CH2-S-(CH2)5-CO-DM is part of the antibody coupling active molecule (drug-linker conjugate for ADC).
V84234	IM-2	2813269-89-3
V76160	LP-6	1629736-79-3	LP-6 is an ADC drug-linker conjugates (Drug-Linker Conjugates for ADC) that can be used for the synthesis of ADC.
V76163	Lys-Nε-SPDB-DM4	1280215-91-9	Lys-Nε-SPDB-DM4 is a drug-linker conjugate, consisting of the potent tubulin inhibitor DM4 and the linker Lys-Nε-SPDB, used to prepare antibody active molecular conjugates (ADC).
V33339	Lys-SMCC-DM1 TFA	1281816-04-3	Lys-SMCC-DM1 is the active metabolite of T-DM1.
V81835	m-PEG-NHS ester (MW 1000) (mPEG-SC (MW 1000); mPEG-Succinimidyl ester (MW 1000))	92451-01-9	m-PEG-NHS ester (MW 1000) may be utilized to modify active molecules and improve their antigenicity and immunogenicity to help prepare injectable preparations.