Sodium channels are membrane proteins that function as ion channels and transport sodium ions (Na+) across the plasma membrane of cells. They are divided into two categories based on what opens the channel for these ions: voltage changes (for voltage-gated, voltage-sensitive, or voltage-dependent sodium channels, also known as VGSCs or Nav channels), or ligand bindings (for ligand-gated sodium channels). The rising phase of action potentials is caused by sodium channels in excitable cells like neurons, myocytes, and some varieties of glia. There are three different states of voltage-gated Na+ channels: deactivated (closed), activated (open), and inactivated (closed). Instead of a change in membrane potential, ligand-gated sodium channels are activated by the binding of a ligand.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
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V1662 | Vinpocetine (RGH-4405; AY-27,255) | 42971-09-5 | Vinpocetine (formerly RGH-4405; AY-27,255;AY27,255,RGH4405, TCV-3B, Cavinton, Intelectol; Ethyl apovincaminate) is a synthetic derivative of the vinca alkaloid vincamine which is a natural product extracted from either the seeds of Voacanga africana or the leaves of Vinca minor as well as the lesser periwinkle plant. |
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V73663 | XPC-6444 | 2230144-21-3 | XPC-6444 is a potent, isoform-selective, CNS-permeable (penetrable) inhibitor of NaV1.6 (IC50=41 nM for hNaV1.6). |
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V1645 | Zonisamide (AD 810; CI 912) | 68291-97-4 | Zonisamide (AD810; CI912;AD-810; CI-912),an antiepileptic drug, is a voltage-dependent sodium channel and T-type calcium channel blocker. |
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V71480 | Zonisamide-d4 (zonisamide d4) | 1020720-04-0 | Zonisamide-d4 is the deuterated form of Zonisamide. |
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V73700 | Zorevunersen (STK-001) | 2415330-04-8 | Zorevunersen (STK-001) is an antisense oligonucleotide that enhances the expression of sodium channel Nav1.1 protein by increasing SCN1A mRNA levels. |
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V73690 | Zorevunersen sodium (STK-001 sodium) | 2415330-05-9 | Zorevunersen sodium is an antisense oligonucleotide that enhances the expression of sodium channel Nav1.1 protein by increasing SCN1A mRNA levels. |
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V77493 | µ-Conotoxin BuIIIA | μ-Conotoxin BuIIIA (Mu-Conotoxin BuIIIA) is a voltage-gated sodium channel (VGSC) blocker. | |
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V73707 | µ-Conotoxin BuIIIB (Mu-Conotoxin BuIIIB) | 1400096-06-1 | μ-Conotoxin BuIIIB (Mu-Conotoxin BuIIIB) is a mammalian neuronal voltage-gated sodium channel (VGSC) blocker. |
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V73699 | µ-Conotoxin BuIIIC (Mu-Conotoxin BuIIIC) | 1400096-08-3 | μ-Conotoxin BuIIIC (Mu-Conotoxin BuIIIC) is a potent Nav1.4 inhibitor. |
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V73681 | µ-Conotoxin KIIIA | 884469-67-4 | μ-Conotoxin KIIIA is an analgesic μ-conotoxin extracted from Conus kinoshitai. |
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V73722 | µ-Conotoxin SIIIA | 877860-32-7 | μ-Conotoxin SIIIA is a tetrodotoxin (TTX)-resistant sodium channel blocker. |
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V77335 | µ-Conotoxin-CnIIIC acetate | µ-Conotoxin-CnIIIC acetate is a 22-amino acid (AA) conopeptide that is a potent antagonist of voltage-gated NaV1.4 sodium channels with IC50 of 1.3 nM at the neuromuscular junction. | |
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V73721 | β-Pompilidotoxin (β-PMTX) | 216064-36-7 | β-Pompilidotoxin (β-PMTX) is a wasp venom that slows sodium channel inactivation and increases steady-state sodium current in cells. |
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V81814 | β-Pompilidotoxin TFA (β-PMTX TFA) | β-Pompilidotoxin TFA (β-PMTX TFA) is a wasp venom that slows sodium channel inactivation and increases steady-state sodium current in cells. | |
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V81819 | δ-Buthitoxin-Hj1a | δ-Buthitoxin-Hj1a is a scorpion venom peptide and a potent NaV1.1 agonist/activator with EC50 of 17 nM. | |
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V81820 | δ-Buthitoxin-Hj2a | δ-Buthitoxin-Hj2a is a scorpion venom peptide and a potent NaV1.1 agonist/activator with EC50 of 32 nM. | |
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V81821 | δ-Theraphotoxin-Hm1a toxin | δ-Theraphotoxin-Hm1a toxin is a selective Nav1.1 activator. | |
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V81822 | δ-Theraphotoxin-Hm1b | δ-Theraphotoxin-Hm1b is a 42-amino acid (AA) peptide extracted from the venom of the Togolese starburst tarantula (Heteroscodra maculata). | |
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V73703 | μ-Conotoxin PIIIA | 184840-20-8 | μ-Conotoxin PIIIA is a sodium channel (NaV 1.4) blocker. |
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V73705 | μ-Conotoxin Sx IIIA | 1400096-00-5 | μ-Conotoxin Sx IIIA is a biologically active peptide. |
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