Sodium channels are membrane proteins that function as ion channels and transport sodium ions (Na+) across the plasma membrane of cells. They are divided into two categories based on what opens the channel for these ions: voltage changes (for voltage-gated, voltage-sensitive, or voltage-dependent sodium channels, also known as VGSCs or Nav channels), or ligand bindings (for ligand-gated sodium channels). The rising phase of action potentials is caused by sodium channels in excitable cells like neurons, myocytes, and some varieties of glia. There are three different states of voltage-gated Na+ channels: deactivated (closed), activated (open), and inactivated (closed). Instead of a change in membrane potential, ligand-gated sodium channels are activated by the binding of a ligand.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V81824 | μ-Conotoxin SxIIIC | μ-Conotoxin SxIIIC is an irreversible NaV channel inhibitor obtained from Conus striolatus. | |
|
V81825 | μ-TRTX-Hd1a | μ-TRTX-Hd1a is a spider venom and a selective NaV 1.7 inhibitor. | |
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V81826 | π-TRTX-Hm3a | π-TRTX-Hm3a is a 37-amino acid (AA) peptide extracted from the venom of the Togolese starburst tarantula (Heteroscodra maculata). | |
|
V73689 | ω-Conotoxin CVIB | 325164-09-8 | ω-Conotoxin CVIB is a non-selective N-type and P/Q-type voltage-gated calcium channel (VGCC) antagonist. |
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