Sodium channels are membrane proteins that function as ion channels and transport sodium ions (Na+) across the plasma membrane of cells. They are divided into two categories based on what opens the channel for these ions: voltage changes (for voltage-gated, voltage-sensitive, or voltage-dependent sodium channels, also known as VGSCs or Nav channels), or ligand bindings (for ligand-gated sodium channels). The rising phase of action potentials is caused by sodium channels in excitable cells like neurons, myocytes, and some varieties of glia. There are three different states of voltage-gated Na+ channels: deactivated (closed), activated (open), and inactivated (closed). Instead of a change in membrane potential, ligand-gated sodium channels are activated by the binding of a ligand.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V1666 | Procaine HCl (Novocaine) | 51-05-8 | Procaine HCl(also known as Novocaine; Gerovital H3; Aminocaine), the HCl salt of Procaine, is alocal anesthetic that acts as an inhibitor of sodium channel, NMDA receptor and nAChR with IC50 of 60 μM, 0.296 mM and 45.5 μM. |
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V1664 | Propafenone HCl (SA-79) | 34183-22-7 | Propafenone HCl(formerly SA-79; SA79;Rytmonorm; Pronon; Arythmol; Baxarytmon; Cuxafenon; Fenoprain),the hydrochloride salt ofPropafenone, is an approved class 1C anti-arrhythmic drug. |
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V73695 | Propafenone-(phenyl-dd5) (hydrochloride) | 93909-48-9 | Propafenone-(phenyl-dd5) ( HCl) is the deuterated form of Propafenone HCl. |
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V73686 | Propafenone-d5 Ethyl hydrochloride (propafenone d5 hydrochloride (Ethyl)) | 1398066-02-8 | Propafenone-d5 Ethyl ( HCl) is the deuterium labelled form of Propafenone HCl. |
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V73728 | Propafenone-d5 hydrochloride (propafenone d5 hydrochloride) | 1346605-05-7 | Propafenone-d5 ( HCl) is the deuterated form of Propafenone HCl. |
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V1653 | Proparacaine HCl | 5875-06-9 | Proparacaine HCl (Proxymetacaine; Proxymetacaine),the hydrochloride salt of proparacaine, is a voltage-gated sodium channels antagonist approved as anophthalmic solution fortopical anesthetic use in ophthalmic practice. |
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V76588 | ProTx II TFA | ProTx II TFA is a selective blocker of Nav1.7 sodium channel with IC50 of 0.3 nM. | |
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V81241 | ProTx-III (μ-TRTX-Tp1a) | ProTx-III is a selective inhibitor of the voltage-gated sodium channel Nav1.7 with IC50 of 2.1 nM. | |
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V73711 | ProTxII | 484598-36-9 | ProTx II is a selective blocker of Nav1.7 sodium channel with IC50 of 0.3 nM. |
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V81251 | Pterinotoxin-1 | Pterinotoxin-1 is a bioactive peptide toxin that can inhibit sodium channels. | |
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V81252 | Pterinotoxin-2 | Pterinotoxin-2 is a bioactive peptide toxin that can inhibit sodium channels. | |
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V73676 | QX-222 chloride | 5369-00-6 | QX-222 chloride is a trimethyl analog of Lignocaine and a potent Na+ channel blocker. |
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V13541 | QX-314 Br | 24003-58-5 | QX-314 Br is a novel intracellular blocker of NaVchannels1-4and a membrane impermeable quaternary analogue of lidocaine, a blocker of voltage-activated Na+ channels. |
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V3620 | Raxatrigine | 934240-30-9 | Raxatrigine (also known as GSK1014802 and CNV-1014802) is a novel, potent small molecule state-dependent sodium channel blocker, the Nav1.7 sodium channel inhibitor. |
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V7461 | Raxatrigine HCl (GSK1014802, CNV1014802) | 934240-31-0 | Raxatrigine (also known as GSK-1014802 and CNV-1014802) is a novel, potent small molecule state-dependent sodium channel blocker, the Nav1.7 sodium channel inhibitor. |
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V73674 | Relutrigine (PRAX-562) | 2392951-29-8 | Relutrigine (PRAX-562) is an orally bioactive, persistent sodium channel inhibitor. |
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V11111 | Ropivacaine HCl hydrate | 132112-35-7 | Ropivacaine HCl hydrate is a novel and potent sodium channelblockerused as ananaesthetic agent, blocking neuropathic pain. |
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V1643 | Rufinamide (CGP 33101; RUF 331) | 106308-44-5 | Rufinamide (also known as CGP-33101; E-2080; RUF-331; BANZEL; Inovelon)is a voltage-gated sodium channel blocker approved as an antiepilepic agent for seizure treatment. |
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V3654 | RY785 | 1393748-80-5 | RY785 is a potent and specific voltage-gated potassium (KV2) channel inhibitor (antagonist) with IC50 of 0.05 μM for KV2.2. |
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V81377 | Scorpion toxin Tf2 | Scorpion toxin Tf2 is a β-scorpion toxin first discovered in the venom of the Brazilian scorpion Tityus fasciolatus. |
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