RNA synthesis, which is also called DNA transcription, is a highly selective process.Beyond RNA synthesis, RNA polymerase II transcription plays a more active role in the maturation, monitoring, and export of mRNA to the cytoplasm.
In order to fully repair the DNA after a single-strand break, DNA ligase constructs the final phosphodiester bond using the complementary strand of the double helix as a template.Substrates with RNA strands or mismatched base pairs near the ends of the nicked DNA are discriminated against by DNA ligases. Bleomycin (BLM) is a S-independent radiomimetic agent that damages DNA by creating free radicals that attack the C-4′ position in the deoxyribose backbone. This causes the ribose ring to open and strand breaks to occur.
M-MuLV Reverse Transcriptase (RNase H) and random hexamer primers are used to create first strand cDNA. The next step involves the use of DNA Polymerase I and RNase H to create second strand cDNA. Exonuclease/polymerase activity transforms the remaining overhangs into blunt ends. DNA fragments' 3′ ends are adenylated before being ligated with a NEBNext Adaptor with a hairpin loop structure to get the samples ready for hybridization. The two pathways that BET bromodomain inhibition most commonly affects are cell cycle and DNA replication. The translation of mRNA into proteins is inhibited by cycloheximide.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V52218 | Crisnatol (BWA770U) | 96389-68-3 | Crisnatol (BWA770U) is a DNA intercalator based on arylmethylaminopropanediol and an oral active anticancer agent. |
|
V1440 | CRT0044876 | 6960-45-8 | CRT0044876 (CRT-0044876;NSC 69877, 7-NO2-ICA; NSC-69877;CRT 0044876;NSC69877), an indole analog, is a potent and selective APE1 inhibitor with potential antitumor activity. |
|
V83610 | CTPS1-IN-1 | 2341943-12-0 | |
|
V83392 | CTPS1-IN-2 | 2377000-84-3 | |
|
V1463 | CX-5461 | 1138549-36-6 | CX-5461 (CX 5461; CX5461) is a novel, selective andorally bioavailable inhibitor of rRNA synthesis and rDNA transcription inhibitor with potential antitumor activity. |
|
V4349 | CX-5461 dihydrochloride | CX-5461 dihydrochloride is a novel, potent, selective andorally bioavailable inhibitor of rRNA synthesis, it selectively inhibits Pol I-driven transcription of rRNA with IC50 of 142 nM in HCT-116, A375, and MIA PaCa-2 cells, has no effect on Pol II, and possesses 250- to 300-fold selectivity for inhibition of rRNA transcription versus DNA replication and protein translation. | |
|
V78930 | Cy5-dATP | Cy5-dATP is Cy5 labeled dATP. | |
|
V1443 | Cyclocytidine HCl (Ancitabine) | 10212-25-6 | Cyclocytidine (formerly NSC-145668;Cyclo-C; NSC145668; Ancitabine) is a pyrimidine nucleoside-basedprodrug of cytarabine that has to be activated through hydrolysis to cytarabine under in vivo conditions. |
|
V3042 | Cycloheximide | 66-81-9 | Cycloheximide, produced by S. griseus, is a glutarimide antibiotic and an inhibitor of protein synthesis in eukaryotes (but not prokaryotes) with IC50 of 5- |
|
V55139 | Cylindrospermopsin | 143545-90-8 | Cylindrospermopsin is a cyanotoxin produced by a variety of freshwater cyanobacteria. |
|
V1459 | Cytarabine | 147-94-4 | Cytarabine (formerly Ara-C; MK-8242; SCH-900242; SCH900242;MK8242; AC-1075; CHX 3311; Arabitin; Aracytidine),a pyrimidine nucleoside analog approved for cancer treatment, is an antimetabolite anticancer drug used mainly for treating leukemia. |
|
V19037 | Cytarabine hydrochloride (MK-8242) | 69-74-9 | Cytarabine hydrochloride (MK-8242; SCH-900242; AC-1075; CHX-3311; Arabitin), thehydrochloride salt of cytarabine, is a pyrimidine nucleoside analog and antimetabolic anticancer agentwith a modified sugar moiety. |
|
V55143 | Cytarabine triphosphate (Ara-CTP) | 13191-15-6 | Cytarabine triphosphate (Ara-CTP), an active metabolite of Cytarabine, is an inhibitor of DNA synthesis that is competitive. |
|
V86148 | Cytarabine triphosphate trisodium (Ara-CTP trisodium) | 1179343-17-9 | |
|
V53214 | Cytidine 5'-diphosphate trisodium salt (CDP) | 34393-59-4 | Cytidine 5'-diphosphate trisodium salt (CDP) is produced by the transfer of a phosphate group from ATP to cytidine monophosphate (CMP) catalyzed by uridine monophosphate kinase (UMPK). |
|
V40642 | D-I03 | 688342-78-1 | D-I03 (DI03) is a novel and potent RAD52 inhibitor (Kd= 25.8 µM) with anticancer activity. |
|
V55126 | D-Xylofuranose, 1,2,3,5-tetraacetate | 42927-46-8 | D-Xylofuranose, 1,2,3,5-tetraacetate is a raw material used in the preparation /synthesis of nucleotides. |
|
V1458 | Dacarbazine (DTIC) | 4342-03-4 | Dacarbazine (formerly also known as DTIC, DTIC-Dome; WR-139007; Asercit; Dacatic; Deticene) is an antitumor chemotherapeutic drug approved by FDA in the 1970s for the treatment of various cancers, including advanced melanoma (major use), Hodgkin lymphoma, sarcoma, and islet cell carcinoma of the pancreas. |
|
V5111 | Dactinomycin (Actinomycin IV; Actinomycin D) | 50-76-0 | Dactinomycin (Actinomycin IV; Actinomycin D), a compound of the actinomycine class, is a polypeptide antibiotic isolated from soil bacteria of the genus Streptomyces. |
|
V75894 | DAM-IN-1 | 935279-95-1 | DMA-IN-1 is a DNA adenine methyltransferase (DAM) inhibitor, IC50= 48 μM. |
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