|
V3608
|
Echinocandin B |
54651-05-7 |
Echinocandin B is a novel and potent cyclic hexapeptide echinocandin antibioticoriginallyisolated from Aspergillus nidulans var. |
|
V3855
|
Ehp-inhibitor |
861249-77-6 |
Ehp inhibitor is a novel and potent inhibitor of EHP. |
|
V3611
|
Enantiomer of Sofosbuvir |
|
Enantiomer of Sofosbuvir is the isomer/enantiomer of Sofosbuvir(also known as PSI-7977, GS-7977; tradenames Sovaldi and Virunon) is a HCV NS5B polymerase inhibitor that is used for the treatment of chronic hepatitis C virus (HCV) infection. |
|
V3618
|
Epelsiban |
872599-83-2 |
Epelsiban (also known asGSK557296; GSK-557296) is a novel, potent, selective and orally bioavailableoxytocin receptorantagonist, with apKiof 9.9 for human oxytocin receptor. |
|
V3638
|
Epetraborole R-Mandelate |
1234563-15-5 |
Epetraborole R-Mandelate (also known as GSK2251052 and AN3365) is a novel, potent and selective leucyl-tRNA synthetase (LeuRS) inhibitor, which inhibits protein synthesis by binding to the terminal adenosine ribose (A76) of leucyl-tRNA synthetase. |
|
V2104
|
Flavoxate sulfate |
15301-69-6 |
Flavoxate sulfate (Rec-7-0040; DW61) is a potent anticholinergic (AChR) agent that binds and inhibits muscarinic receptors, thereby suppressing the micturition reflex and increases urinary bladder capacity by modifying the micturition center in the brain stem. |
|
V3587
|
Foretinib-Based PROTAC 7 |
2230821-68-6 |
Foretinib-Based PROTAC 7 is a novel, potent and selective VHL-recruiting PROTAC that induces the degradation of c-Met in a dose- and time-dependent fashion in MDA-MB-231 cells. |
|
V3897
|
Fosnetupitant |
1703748-89-3 |
Fosnetupitant (07PNET; 07-PNET; Fosnetupitant chloride; Akynzeo), the prodrug of netupitant,is a novel and potentantagonist of neurokinin receptor usedin combination with palonosetron to prevent nausea and vomiting caused by chemotherapy. |
|
V3507
|
Fosravuconazole |
351227-64-0 |
Fosravuconazole (formerly known as E-1224, BEF-1224, and BMS-379224) is an azole-based antifungal agent that can be potentially used for the treatment of fungal infections. |
|
V2128
|
GNE-0723 |
1883518-31-7 |
GNE 0723 is a novel, potent, brain permeable positive allosteric modulator (PAM) and GluN2A subunit-selective ofNMDAR, with anEC50of 21 nM for GluN2A, 7.4 and 6.2 μM for GluN2C and GluN2D, respectively. |
|
V2125
|
GNE-207 |
2158266-58-9 |
GNE-207 is a novel, potent, selective and orally bioavailable inhibitor of the bromodomain ofCBP. |
|
V2131
|
GNE-371 |
1926986-36-8 |
GNE-371 is a novel, potent and selective chemical probe for the second bromodomains of human transcription-initiation-factorTFIIDsubunit 1 and transcription-initiation-factorTFIIDsubunit 1-like with anIC50of 10 nM for TAF1(2). |
|
V2126
|
GNE-493 |
1033735-94-2 |
GNE-493 is a novel, potent, selective, and orally bioavailable dualpan-PI3-kinase/mTORinhibitor withIC50s of 3.4 nM, 12 nM, 16 nM, 16 nM and 32 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ and mTOR. |
|
V2130
|
GNE-5729 |
2026635-66-3 |
GNE 5729 is a novel, potent, brain permeable positive allosteric modulator (PAM) and GluN2A subunit-selective ofNMDAR with anEC50of 37 nM for GluN2A, 4.7 and 9.5 μM for GluN2C and GluN2D, respectively. |
|
V2123
|
GNE-6468 |
1677668-27-7 |
GNE-6468 is a novel, potent and selectiveRORγ (RORc)agonists with anEC50value of 13 nM in HEK-293 cells. |
|
V2133
|
GNE684 |
|
GNE684 is a novel and potent inhibitor ofreceptor interacting protein 1 (RIP1), it inhibits human RIP1 potently over than mouse and rat withIC50s of 21 nM, 189 nM and 691 nM, respectively. |
|
V2122
|
GNF179 |
1261114-01-5 |
GNF179, an optimized 8,8-dimethylimidazolopiperazine analog,is a novel, potent and orally bioavailable antiparasitic agent that exhibited the potency(4.8 nM against the multidrug resistant strain W2) in vitro metabolic stability and in vivo oral bioavailability. |
|
V3539
|
GSK-269984A |
892664-04-9 |
GSK-269984A is a novel and potentProstaglandin E2 Receptor 1 (EP1)antagonist with apIC50of 7.9. |
|
V2062
|
GSK1379725A |
1802251-00-8 |
GSK1379725A (AU1) is the first small molecule selective for BPTF over Brd4, as an inhibitor ofBrd4and a selective BPTF ligand with Kdof 2.8 μM. |
|
V3592
|
GSK2973980A |
1414797-35-5 |
GSK2973980A is a novel, potent and selective inhibitor ofAcyl-CoA:diacylglycerol acyltransferase 1 (DGAT1)with anIC50of 3 nM. |