The p38 MAPK family consists of highly conserved proline-directed serine-threonine protein kinases that are activated in response to a number many growth factors, cytokines, and chemotactic substances, such as vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), PDGF, TNF, interleukins, lipopolysaccharide (LPS) and formyl-methionyl-leucyl-phenylalanine (fMLP).It is well known that p38 plays a role in cell differentiation, cardiomyocyte hypertrophy, apoptosis, and inflammation.
The four proteins that make up the p38 MAPK family are p38 (encoded by the gene Mapk14), p38 (Mapk11), p38 (Mapk12), and p38 (Mapk13). Their coding genes appear to be differentially expressed and have a distinct tissue distribution, with Mapk14 being the most highly expressed. MKK6, MKK3, and MKK4 are three MAP2Ks that p38 MAPKs are a substrate for. Depending on the stimulus and the cell type, each of these MAP2Ks plays a different role in the activation of p38 MAPKs. ASK1, DLK1, TAK1, TAO1, TAO2, TPL2, MLK3, MEKK3, MEKK4, and ZAK1 are the MAP3Ks that activate p38 MAPKs.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V74105 | Darizmetinib | 2369583-33-3 | Darizmetinib is an inhibitor (blocker/antagonist) of mitogen-activated protein kinase kinase (MAP2K). |
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V69833 | DCZ19931 | 2789629-84-9 | DCZ19931 is a potent multi-targeted kinase inhibitor. |
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V74111 | Dehydromiltirone (1,2-Didehydromiltirone) | 116064-77-8 | Dehydromiltirone (1,2-Didehydromiltirone) is a diterpene quinone with anti-inflammatory activities. |
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V74115 | Deoxysappanone B (3-Deoxysappanone B) | 113122-54-6 | Deoxysappanone B (3-Deoxysappanone B) is an isoflavone compound extracted from Caesalpinia sappan L (Lignum Sappan). |
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V3748 | Dilmapimod (SB-681323) | 444606-18-2 | Dilmapimod (SB-681323; GW-681323) is a novel p38 MAPK (mitogen-activated protein kinase) inhibitor that has the potential to treat inflammatory diseases such as COPD (chronic obstructive pulmonary disease) and RA (Rheumatoid Arthritis). |
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V51072 | DL-Syringaresinol | 1177-14-6 | inhibitor of MAPK/AP-1 signaling |
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V74122 | EGF-R (661-681) T669 Peptide | 137348-21-1 | EGF-R (661-681) T669 Peptide is a MAPK substrate and may be utilized to measure MAPK catalytic activity. |
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V51549 | Emodic acid (NSC-624610) | 478-45-5 | natural anthraquinone; NF-κB inhibitor |
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V74128 | Emprumapimod (PF-07265803) | 765914-60-1 | Emprumapimod (PF-07265803) is an orally bioactive, selective p38α MAPK inhibitor that directly inhibits LPS-induced IL-6 production in RPMI-8226 cells (IC50=100 pM). |
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V77040 | Emprumapimod hydrochloride (PF-07265803 hydrochloride) | Emprumapimod (PF-07265803) HCl is an orally bioactive and selective p38α MAPK inhibitor. | |
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V1977 | Esculin | 531-75-9 | Esculin is a naturally occuring coumarin glucoside that is isolated from the horse chestnut (Aesculus hippocastanum), California Buckeye (Aesculus californica), Prickly Box (Bursaria spinosa) and in daphnin (the dark green resin of Daphne mezereum). |
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V74108 | Esculin sesquihydrate (esculin sesquihydrate) | 66778-17-4 | Esculin sesquihydrate is a fluorescent coumarin glucoside, the active ingredient in ash bark. |
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V67591 | EW-7195 | 1352609-28-9 | EW-7195 is a potent and specific ALK5 (TGFβR1) inhibitor (antagonist) with IC50 of 4.83 nM. |
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V74119 | Ganoderterpene A | 2682180-85-2 | Ganoderterpene A alleviates LPS-induced inflammation and apoptosis by inhibiting MAPK and TLR-4/NF-κB pathways in BV-2 cells. |
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V73182 | Iroxanadine sulfate ((-)-BRX 005 sulfate; (-)-BRX 235 sulfate) | 276690-61-0 | Iroxanadine ((-)-BRX 005) sulfate is a potent activator of p38 kinase and an enhancer of stress-responsive heat shock protein (Hsp) expression. |
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V74129 | JNJ-49095397 (RV568) | 1220626-82-3 | JNJ-49095397 (RV568) is an inhaled narrow-spectrum kinase inhibitor (NSKI) that can inhibit the α and γ isoforms of p38 MAPK. |
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V0485 | Losmapimod (GW0856553X; SB0856553) | 585543-15-3 | Losmapimod (formerly known as GSK-AHAB; GSK AHAB; GW856553,SB856553 or GW-856553X) is a novel, selective, potent, and orally bioavailable inhibitor of p38 MAPK (p38 mitogen-activated protein kinases) with potentialantidepressant, anti-hypertensive and anti-inflammatory activity. |
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V74114 | Macranthoin G (Methyl 3,5-dicaffeoyl quinic acid) | 159934-13-1 | Macranthoin G is an inhibitor (blocker/antagonist) of p38 MAPK. |
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V74104 | MBP MAPK Substrate | 138028-00-9 | MBP MAPK Substrate can be used as an exogenous substrate for MAPK. |
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V9029 | Metformin | 657-24-9 | Metformin (La-6023; SMP-862; ADX-155; EFB-0027; EX404; La6023; SMP862; Fortamet) is an approved hypoglycemic drug for the treatment of type 2 diabetes (non-insulin-dependent diabetes mellitus). |
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