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Phosphatase

Phosphatase

Phosphatases are enzymes that strip a protein of its phosphate group. PTPs (protein tyrosine phosphatases) are a large family of cytoplasmic and transmembrane enzymes. PTPs are crucial in maintaining the integrity of cell-cell and cell-matrix contacts as well as controlling the proliferative activity of cells. PTP1B, a non-receptor PTP, is frequently found in the endoplasmic reticulum and in vesicles that are close to the plasma membrane.PTP1B has been a popular therapeutic target for the management of type 2 diabetes mellitus and obesity due to its important role as a negative regulator of leptin receptor pathways. Animal cell cytoplasm contains four major serine/threonine-specific protein phosphatase catalytic subunits. While PP2C seems to be different from the other two, PP1, PP2A, and PP2B, all three of these enzymes are members of the same gene family. A diverse group of enzymes known as alkaline phosphatases is found in abundance in mammalian cells. Following the general equation, acid phosphatase enzymes catalyze the hydrolysis of phosphate monoesters.

Phosphatase related products

Structure Cat No. Product Name CAS No. Product Description
V73301 D-3 1967815-98-0 D-3 is a phosphorylated peptide and an efficient, simple and specific IPSC elimination agent.
V73303 DA 3003-2 (NSC663285) 383907-47-9 DA 3003-2 is a potent and specific Cdc25 inhibitor.
V71456 Deoxyneocryptotanshinone 27468-20-8 Deoxyneocryptotanshinone is a natural tanshinone and a high-affinity BACE1 (Beta-secretase) inhibitor (antagonist) with IC50 of 11.53 μM.
V77068 DPM-1001 trihydrochloride DPM-1001 tri HCl is a potent, specific, orally bioactive, and noncompetitive protein tyrosine phosphatase (PTP1B) inhibitor (antagonist) with IC50 of 100 nM.
V73293 EGF Receptor Substrate 2 (Phospho-Tyr5) 149261-42-7 EGF Receptor Substrate 2 (Phospho-Tyr5) acetate, a biologically active peptide, is a tyrosine phosphate substrate.
V73298 Endothall (Endothal; Endothal) 145-73-3 Endothall (Endothal) is a protein phosphatase 2A (PP2A) inhibitor (antagonist) with IC50s of 90 nM and 5 µM for PP2A and PP1, respectively.
V70203 Eudebeiolide B (Plebeiolide D) 1934299-51-0 Eudebeiolide B is a compound that can be extracted from lychee grass.
V73355 Eurestobart 2682847-53-4 Eurestobart is a humanized IgG1κ antibody targeting ENTPDase.
V20890 F1063-0967 613225-56-2 F1063-0967 is a dual-specificity phosphatase 26 (DUSP26) inhibitor (antagonist) with IC50 of 11.62 μM.
V73285 GNF362 1003019-41-7 GNF362 is a selective and orally bioavailable inhibitor of inositol trisphosphate 3' kinase B (Itpkb) with IC50 of 9 nM.
V69758 GS-493 1710337-31-7 GS-493 is a selective inhibitor of tyrosine phosphatase SHP2 (PTPN11) with IC50 of 71 nM and is 29-fold and 45-fold more active against SHP2 than SHP1 and PTP1B.
V3535 GSK 2830371 1404456-53-6 GSK-2830371 (GSK2830371) is a first-in-class, potent, orally bioactive and highly selective allosteric inhibitor of Wip1 (wild-type p53-induced phosphatas) phosphatase with potential anticancer activity.
V79812 h-NTPDase-IN-1 h-NTPDase-IN-1 (Compound 3i) is an h-NTPDase inhibitor (IC50 for h-NTPDase1 and h-NTPDase3 are 2.88 μM and 0.72 μM, respectively).
V73348 h-NTPDase-IN-2 2939933-03-4 h-NTPDase-IN-2 (compound 3l) is a pan-inhibitor of NTPDase with IC50s of 0.35 μM (h-NTPDase1), 4.81 μM (h-NTPDase2), 37.73 μM (h-NTPDase3), 10.32 μM (h- NTPDase8).
V73327 h-NTPDase-IN-3 2939933-10-3 h-NTPDase-IN-3 (compound 4d) is a pan-inhibitor of NTPDase, with IC50s of 34.13 μM (h-NTPDase1), 0.33 μM (h-NTPDase2), 23.21 μM (h-NTPDase3), and 2.48 μM (h- NTPDase8).
V73344 h-NTPDase-IN-4 2939933-09-0 h-NTPDase-IN-4 (compound 4c) is a pan-inhibitor of NTPDase with IC50s of 3.58 μM (h-NTPDase1), 10.21 μM (h-NTPDase2), 0.13 μM (h-NTPDase3), 13.57 μM (h- NTPDase8).
V73336 h-NTPDase-IN-5 2939932-93-9 h-NTPDase-IN-5 (compound 3b) is a pan-inhibitor of NTPDase, with IC50s of 1.10 μM (h-NTPDase1), 44.73 μM (h-NTPDase2), 26.14 μM (h-NTPDase3), and 0.32 μM (h- NTPDase8).
V51567 HKB-99 2414908-90-8 HKB99 is an allosteric dye formed by phosphoglycerate mutase 1 (PGAM1).
V69747 IACS-15414 2411321-29-2 IACS-15414 is an orally bioactive SHP2 inhibitor (antagonist) with IC50 of 122 nM.
V22435 Idoxuridine 54-42-2 Idoxuridine (IdUrd; 5-Iodo-2′-deoxyuridine; 5-IUdR) is a potent anti-herpesvirus antiviral and anticancer drug.
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