The positive-strand RNA virus known as hepatitis C virus (HCV) belongs to the family Flaviviridae's genus Hepacivirus. At least six genotypes (gt) of HCV exist, and the polymerase's error-prone nature results in more than 50 subtypes. The host and viral proteases break down the long open reading frame, which encodes the HCV polyprotein, into seven nonstructural (NS) proteins (p7, NS2, NS3, NS4A, NS4B, NS5A, and NS5B) and three structural proteins (the capsid protein core and envelope glycoproteins E1 and E2). While NS3 to NS5B are involved in a membrane-associated RNA replicase complex (RC), NS2 and p7 are required for virus assembly but not RNA replication.NS4A acts as a cofactor for the NS3 serine protease, NS5B is the RNA-dependent RNA polymerase, and NS5A is thought to play important roles in numerous stages of the HCV life cycle. The NS3 protein is made up of a serine protease and an RNA helicase/nucleoside triphosphatase (NTPase).After being administered to HCV-infected cells, NS5A inhibitors quickly reduce the virus' ability to infect cells.
By preventing Kv2.1 function and preventing apoptosis, the HCV protein NS5A prevents the loss of intracellular potassium that would otherwise occur in hepatocytes.
Alpha interferon, Telaprevir, the NS5A inhibitor BMS-790052, and PSI-7977, as well as the combination of lucidone and alpha interferon, all work synergistically to inhibit HCV RNA replication.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V52003 | HCV Peptide (35-44) | 160214-01-7 | HCV (hepatitis C virus) Peptide (35-44) is the HCV (hepatitis C virus) core protein located at positions 35 to 44 and is an HLA-A2 restricted CTL epitope. |
|
V54222 | HCV-1 e2 Protein (484-499) | 161012-10-8 | HCV (hepatitis C virus)-1 e2 protein (484-499) is a bioactive peptide consisting of 16 amino acid (AA)s. |
|
V54218 | HCV-1 e2 Protein (554-569) | 290362-31-1 | HCV (hepatitis C virus)-1 e2 Protein (554-569) is one of the major antigenic regions of the HCV (hepatitis C virus) envelope 2 (e2) protein. |
|
V79717 | HCV-1 e2 Protein (554-569) (TFA) | HCV (hepatitis C virus)-1 e2 Protein (554-569) TFA is one of the major antigenic regions of the HCV (hepatitis C virus) envelope 2 (e2) protein. | |
|
V52923 | HCV-IN-31 | 1998705-62-6 | HCV (hepatitis C virus)-IN-31 (compound 4) is an inhibitor (blocker/antagonist) of HCV (hepatitis C virus), and its EC50/EC95 value of inhibiting HCV (hepatitis C virus) replicon is 15.7 μM. |
|
V54223 | HCV-IN-43 | 1850311-28-2 | HCV (hepatitis C virus)-IN-43 (compound 2) is an HCV (hepatitis C virus) NS5B protein inhibitor that can effectively inhibit the replication of HCV (hepatitis C virus). |
|
V54229 | HCV-IN-44 | 1850311-55-5 | HCV (hepatitis C virus)-IN-44 (compound 28) is an HCV (hepatitis C virus) NS5B protein inhibitor that can effectively inhibit the replication of HCV (hepatitis C virus). |
|
V54237 | HCVP-IN-1 | 877225-09-7 | HCV (hepatitis C virus)P-IN-1 (compound 1) is an inhibitor (blocker/antagonist) of hepatitis C virus polymerase (HCV (hepatitis C virus)P). |
|
V54236 | Hepatitis C Virus S5A/5B | 191529-67-6 | Hepatitis C Virus S5A/5B is a synthetic peptide substrate. |
|
V54217 | Hepatitis Virus C NS3 Protease Inhibitor 2 | 208939-95-1 | Hepatitis Virus C NS3 Protease Inhibitor 2 is a product-based peptide inhibitor of hepatitis C virus protease (HCV (hepatitis C virus) NS3 protease) with a Ki of 41 nM. |
|
V22524 | Inarigivir soproxil (SB9200) | 942123-43-5 | Inarigivir soproxil, formerly known as SB 9200, is a potent antiviral agent. |
|
V54232 | ISIS 14803 | 223603-41-6 | ISIS 14803 is an antisense thiooligonucleotide that binds to the translation initiation region of HCV (hepatitis C virus) RNA at the internal ribosome entry site (IRES) and inhibits protein expression. |
|
|
V80399 | ISIS 14803 sodium | ISIS 14803 sodium is an antisense thio-oligonucleotide that binds to the translation initiation region of HCV (hepatitis C virus) RNA at the internal ribosome entry site (IRES) and inhibits protein expression. | |
|
V54239 | Isoeuphorbetin (Isoeuphorbetin; Isoeuphorbetin) | 50886-61-8 | Isoeuphorbetin, a dimeric coumarin extracted from Viola philippica, is a potent HCV (hepatitis C virus) protease inhibitor (antagonist) with IC50 of 3.63 µg/mL. |
|
V53035 | ITMN 4077 | 790305-05-4 | ITMN 4077 is a macrocyclic inhibitor that can suppress HCV (hepatitis C virus) NS3 protease activity (EC50= 2131 nM). |
|
V3509 | Ledipasvir acetone | 1441674-54-9 | Ledipasvir acetone (previously known as GS5885; GS-5885 acetone;Harvoni) is an HCV NS5A polymerase inhibitor with anti-HCV activity. |
|
V3508 | Ledipasvir D-tartrate | 1502654-87-6 | Ledipasvir D-tartrate (also known as GS5885 D-tartrate), the D-tartrate salt of Ledipasvir, is an HCV NS5A polymerase inhibitor that has been approved for use in combination with sofosbuvir (trade name Harvoni) for the treatment of hepatitis C virus infection. |
|
V25297 | Merimepodib | 198821-22-6 | Merimepodib, formerly known as VX-497, is orally bioavailable IMPDH inhibitor, which inhibits the proliferation of primary human, mouse, rat, and dog lymphocytes at concentrations of approximately 100 nM. |
|
|
V24503 | OX02983 | 1000120-98-8 | Mipomersen (ISIS 301012 free base) is an antisense oligonucleotide inhibitor of apolipoprotein B (apoB). |
|
V41193 | Miravirsen (SPC-3649) | 1072874-90-8 | Miravirsen (SPC-3649) is a potent inhibitor of miR-122 and inhibits the biogenesis of miR-122. |
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
