The central nervous system contains a family of enzymes known as cholinesterase (ChE), which catalyzes the hydrolysis of the neurotransmitter acetylcholine into choline and acetic acid. This reaction is required for cholinergic neurons to return to their resting state after activation. It is one of many crucial enzymes required for the healthy operation of human nervous systems.
There are two: butyrylcholinesterase (BChE, acylcholine acylhydrolase), also referred to as nonspecific cholinesterase or pseudocholinesterase, and acetylcholinesterase (AChE, acetylcholine hydrolase). While BChE is made in the liver and is mainly found in plasma, AChE is mainly found in the blood on the membranes of red blood cells, at neuromuscular junctions, and in neural synapses. The relative substrate preferences of the two types of cholinesterase are different: AChE hydrolyzes acetylcholine more quickly while BChE hydrolyzes butyrylcholine more quickly.
Structure | Cat No. | Product Name | CAS No. | Product Description |
---|---|---|---|---|
V70437 | Bis(7)-tacrine dihydrochloride | 224445-12-9 | Bis(7)-tacrine di-HCl is a dimeric acetylcholinesterase (AChE) inhibitor found in tacrine. | |
V78055 | Bis-(-)-8-demethylmaritidine | Bis-(-)-8-demethylmaritidine is a naturally occurring alkaloid and a potent acetylcholinesterase (AChE) inhibitor. | ||
V71707 | Broussonin A | 73731-87-0 | Broussonin A is a potent BChE inhibitor (antagonist) with IC50 of 4.16 µM. | |
V78865 | BuChE-IN-7 | BuChE-IN-7 is a selective inhibitor of hBuChe and eqBuChE with IC50 of 40 nM and 80 nM respectively. | ||
V78573 | BuChE-IN-8 | BuChE-IN-8 (compound 19c) is a butyrylcholinesterase (BuChE) inhibitor (antagonist) with IC50 of 559 nM. | ||
V78510 | BuChE-IN-9 | BuChE-IN-9 (compound 22a) is a potent horse serum-derived BuChE (eqBuChE) inhibitor (antagonist) with IC50 of 173 nM. | ||
V71655 | Chikusetsusaponin Ib | 59252-87-8 | Chikusetsusaponin Ib has anti-Alzheimer's disease (AD) activity and is a potent AChE inhibitor. | |
V71653 | Chlorpyrifos-d10 | 285138-81-0 | Chlorpyrifos-d10 is the deuterated form of Chlorpyrifos. | |
V71622 | Chlorpyrifos-oxon | 5598-15-2 | Chlorpyrifos-oxo, an bioactive metabolite of Chlorpyrifos, is a potent phosphorylating agent that effectively inhibits AChE. | |
V71632 | Chlorpyrifos-oxon-d10 | 1794779-85-3 | Chlorpyrifos-oxon-d10 is the deuterated form of Chlorpyrifos-oxon. | |
V77148 | Choline Chloride-13C3 (Choline Chloride 13C3) | Choline Chloride-13C3 is a 13C (carbon 13)-labeled choline (chloride). | ||
V71616 | Choline-d4 chloride (choline d4 chloride (chloride)) | 285979-70-6 | Choline-d4 (chloride) is the deuterated form of Choline chloride. | |
V71617 | Choline-d9 chloride (choline d9 chloride (chloride)) | 61037-86-3 | Choline-d9 (chloride) is the deuterated form of choline chloride. | |
V17505 | Corynoline | 18797-79-0 | Corynoline is a reversible and noncompetitive inhibitor of acetylcholinesterase (AChE) with IC50 of 30.6 μM. | |
V71680 | Cyanidin-3-O-galactoside chloride (cyanidin galactoside; Ideain chloride) | 27661-36-5 | Cyanidin-3-O-galactoside chloride (Ideain chloride) is one of the components found in hawthorn peel (EPHF), with a content of 179.4 mg/g. | |
V71633 | Cyclopenin ((±)-Isocyclopenine) | 19553-26-5 | Cyclopenin ((±)-Isocyclopenine) is a racemic form. | |
V71660 | Dehydrodicentrine | 19843-03-9 | Dehydrodicentrine is an aporphine alkaloid extracted from the roots of S. epigaea and has an inhibitory effect on acetylcholinesterase (AChE) with IC50 of 2.98 μM. | |
V71640 | Dehydrodiscretamine chloride | 78134-82-4 | Dehydrodiscretamine chloride is a dual (bifunctional) inhibitor of AChE and BChE with IC50 of 17.8 and 118.8 μM respectively. | |
V71638 | Dehydrogeizerin | 16850-91-2 | Dehydrogeizerin is an inhibitor (blocker/antagonist) of acetylcholinesterase with IC50 of 9.7 μM. | |
V29399 | Dehydronuciferine | 7630-74-2 | Dehydronuciferine, extracted from the leaves of Nelumbo nucifera Gaertn, is an acetylcholinesterase (AChE) inhibitor (antagonist) with IC50 of 25 μg/mL. |