As the primary component of the amyloid plaques seen in the brains of Alzheimer patients, amyloid- (A) refers to peptides of 36–43 amino acids that are crucially involved in Alzheimer's disease. The amyloid precursor protein (APP), which is cut by specific enzymes to produce A, produces the peptides. Amyloid molecules can group together to create a variety of flexible, soluble oligomers.A amyloid-peptide buildup results from excessive A production or malfunctioning clearance mechanisms. Amyloid- forms diffuse and neuritic plaques in the parenchyma and blood vessels by self-aggregating into oligomers of various sizes. Strong synaptotoxins, proteasome inhibition, mitochondrial inhibition, alteration of intracellular Ca2+ levels, and induction of inflammatory processes are all characteristics of amyloid-oligomers and plaques. Neuronal dysfunction is also thought to be influenced by the loss of A's typical physiological functions.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V18783 | CRANAD-2 | 1193447-34-5 | CRANAD-2 is adifluoroboron-based curcumin acting as anear-infrared (NIR) Aβ plaque-specific fluorescent probe for in vivo detection of amyloid-beta deposits. |
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V87774 | Cy5-β-Amyloid (42-1), human | Cy5-β-Amyloid (42-1), human is β-Amyloid (42-1, human) peptide labeled with Cy5 fluorescence (λex= 633 nm, λem= 670 nm). | |
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V71377 | D-KLVFFA | 342877-55-8 | D-KLVFFA is an inhibitor (blocker/antagonist) of Amyloid-β assembly with IC50 of 2.6 μM. |
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V80071 | DDC 2′,3′-O-disulfate | DDC 2′,3′-O-disulfate (compound 4) prevents fibrillation and oligomerization of Aβ42. | |
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V71362 | Direct Red 80 (Sirius Red; Sirius Red) | 2610-10-8 | Direct Red 80 (Sirius Red) is a polyazo dye primarily used in staining methods for collagen and amyloid. |
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V101326 | DN5355 | 937012-09-4 | DN5355 is a bifunctional small molecule compound targeting amyloid β protein (Aβ) and hyperphosphorylated tau protein. It can inhibit the aggregation of Aβ and tau proteins and dissociate the formed Aβ and tau protein fibers. It can be used in the study of Alzheimer's disease. |
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V11347 | Emrusolmin (Anle138b) | 882697-00-9 | Anle138b is a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease. |
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V1315 | EUK 134 | 81065-76-1 | EUK 134 (EUK-134; EUK134), a synthetic and cell permeable superoxide dismutase (SOD)/catalase mimetic, is a novel antioxidant compound that exhibits potent antioxidant activities. |
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V79435 | FITC-β-Ala-β-Amyloid (25-35) | FITC-β-Ala-β-Amyloid (25-35) is a fluorescent product labeled by FITC and may be utilized in the research of AD/Alzheimer's disease. | |
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V79436 | FITC-β-Amyloid (25-35) | FITC-β-Amyloid (25-35) is FITC labeled β-Amyloid (25-35). | |
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V71357 | Fmoc-Ala-Glu-Asn-Lys-NH2 | 220701-06-4 | Fmoc-Ala-Glu-Asn-Lys-NH2 is a selective asparagine endopeptidase AEP inhibitory peptide that can inhibit the cleavage of amyloid precursor protein APP. |
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V2810 | FPS-ZM1 | 945714-67-0 | FPS-ZM1 is a potent and high-affinityRAGEspecific blocker with Kivalue of 25 nM. |
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V71440 | Glp-amyloid-β (3-40) peptide (human) (AβpE3-40) | 161818-04-8 | Glp-Amyloid-β (3-40) Peptide (human) (AβpE3-40) is a small amount of pyroglutamic acid-modified Aβ extracted from 24-month-old amyloid precursor protein transgenic mice. |
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V79396 | Glutaminyl Cyclase Inhibitor 5 | 3033553-63-5 | Glutaminyl Cyclase Inhibitor 5 (Compound 71) is a potent and specific inhibitor of human glutaminyl cyclase (hQC) with IC50 of 3.2 nM. |
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V87776 | Glutaminyl Cyclase Inhibitor 6 | Glutaminyl Cyclase Inhibitor 6 (compound BI-43) is a secretory glutaminyl cyclase (sQC) and golgi-resident glutaminyl cyclase (gQC) inhibitor with IC50 values of 0.012 and 0.040 µM, respectively. | |
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V104260 | Glutaminyl cyclases-IN-2 | ||
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V79691 | hAChE-IN-3 | 2983723-56-2 | hAChE-IN-3 (compounds 5c) is a potent and BBB (blood-brain barrier) permeable (penetrable) inhibitor of AChE, BuChE, MAO-B-IN-1 and BACE-1 with IC50s of 0.44, 0.08, 5.15 and 1, respectively. |
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V79693 | hAChE-IN-5 | hAChE-IN-5 (compound 49) is a potent inhibitor of hAChE and hBuChE with IC50s of 0.17 μM and 0.17 μM, respectively. | |
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V79406 | hAChE/hBACE-1-IN-2 | hAChE/hBACE-1-IN-2 is a potent, orally bioactive, BBB (blood-brain barrier) permeable (penetrable) triple inhibitor of hAChE/hBChE/hBACE-1 with IC50s of 0.113 μM, 1.48 μM and 0.38 μM respectively. | |
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V71389 | Heishuixiecaoline A | 1469493-85-3 | Heishuixiecaoline A is a sesquiterpenoid. |
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