The G protein-coupled receptor superfamily includes several subtypes of neuropeptide Y receptors. The terms Y1, Y2, Y4, Y5, and Y6 refer to the five cloned NPY receptor subtypes in mammals. Vasoconstriction and feeding are two physiological responses that are mediated by neuropeptide Y receptors.
Humans express the Y1, Y2, Y4, and Y5 subtypes. They are primarily found in tissues like the cardiovascular system and the central and peripheral nervous systems. The neurotransmitter Neuropeptide Y, as well as the hormones peptide YY (PYY) and pancreatic polypeptide (PP), are their physiological ligands.
Important biological and pathophysiological processes like blood pressure, neuroendocrine secretions, seizures, neuronal excitability, and neuroplasticity are regulated by neuropeptide Y and its receptors.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V76708 | Neuropeptide Y (human) (TFA) | Neuropeptide Y (human) TFA is associated with Alzheimer's disease (AD) and protects mouse cortical neurons against amyloid toxicity. | |
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V70828 | Neuropeptide Y Y1 receptor antagonist 1 | 2773476-40-5 | Neuropeptide Y Y1 receptor antagonist 1 (compound 39), a fluorescent probe, is an antagonist of neuropeptide Y Y1 receptor (Y1R) with a Ki of 0.19 nM. |
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V70830 | Neuropeptide Y5 receptor ligand-1 | 322723-35-3 | Neuropeptide Y5 receptor ligand-1 (compound 54) is a carbazole analogue and a potent neuropeptide Y5 (NPY-5) receptor blocker (antagonist). |
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V4393 | NTNCB hydrochloride | 191931-56-3 | NTNCB (Compound 11) HCl is a potent and specific neuropeptide Y5 (NPY Y5) receptor blocker (antagonist) with Ki of 8 nM for human Y5. |
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V70834 | Pancreatic polypeptide | 59763-91-6 | Pancreatic polypeptide is a polypeptide secreted by PP cells in the pancreatic endocrine system. |
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V70829 | Peptide YY (PYY) (3-36), Human | 123583-37-9 | Peptide YY (PYY) (3-36), Human is an endogenous appetite suppressant peptide. |
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V76640 | Peptide YY (PYY) (3-36), porcine TFA | Peptide YY (PYY) (3-36), porcine TFA is a gastrointestinal hormone peptide that works as a Y2 receptor agonist and can reduce appetite. | |
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V76559 | RF9 hydrochloride | RF9 HCl is a potent and specific neuropeptide FF receptor antagonist (inhibitor) with Kis of 58 and 7 nM for hNPFF1R and hNPFF2R respectively. | |
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V70821 | RFRP-1(human) | 311309-25-8 | RFRP-1(human) is a homolog of gonadotropin-inhibiting hormone (GnIH). |
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V81291 | RFRP-1(human) TFA | RFRP-1(human) TFA is a potent endogenous NPFF receptor agonist (EC50s are 0.0011 and 29 nM for NPFF2 and NPFF1, respectively). | |
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V81292 | RFRP-3(human) TFA (Neuropeptide VF(124-131)(human) TFA) | RFRP-3 (Neuropeptide VF(124-131)) (human) TFA, a human GnIH peptide homolog, is a potent inhibitor of gonadotropin secretion and Ca2+ mobilization. | |
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V40180 | SHA 68 | 847553-89-3 | SHA 68 (SHA-68, SHA68)is a novel, highly potent and selective non-peptide neuropeptide S receptor (NPSR) antagonist with IC50s of 22.0 and 23.8 nM for NPSR Asn107 and NPSR Ile107, respectively. |
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V70820 | Spexin (Neuropeptide Q) | 1370290-58-6 | Spexin is a conserved peptide with roles as a neurotransmitter/neuromodulator and an endocrine factor. |
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V81425 | Spexin TFA (Neuropeptide Q TFA) | Spexin TFA is a potent galanin receptor 2/3 (GAL2/GAL3) agonist (EC50s are 45.7 and 112.2 nM, respectively). | |
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V70836 | Y1R probe-1 | 2773476-41-6 | Y1R probe-1 (Compound 39) is a high-affinity fluorescent probe for the neuropeptide Y Y1 receptor. |
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