The class of proteins known as Sirtuin (Sir2 proteins) includes enzymes with deacylase, deacetylase, desuccinylase, demalonylase, demyristoylase, and depalmitoylase activity. Sirtuins control crucial biological processes in eukaryotes, archaea, and bacteria. Sirtuins have been linked to a variety of cellular functions, including energy efficiency and alertness under low-calorie conditions as well as aging, transcription, apoptosis, inflammation, and stress resistance. Circadian clocks and mitochondrial biogenesis can both be regulated by sirtuins.
Structure | Cat No. | Product Name | CAS No. | Product Description |
---|---|---|---|---|
V2900 | Thiomyristoyl | 1429749-41-6 | Thiomyristoyl, a thiomyristoyl lysine compound, is a novel, potent and specific SIRT2 inhibitor with IC50 of 28 nM. | |
V75476 | WAY-354574 | 851873-40-0 | WAY-354574 is a bioactive molecule targeting deacetylase (Sirtuin) and may be utilized in study/research of Huntington's disease (HD). | |
V75477 | YK-3-237 | 1215281-19-8 | YK-3-237 is a SIRT1 activator targeting mutant p53. | |
V55735 | Z26395438 | 2803-63-6 | Z26395438 (compound 1) is an inhibitor (blocker/antagonist) of Sirtuin-1 with IC50 of 1.6 μM. |