Microtubules are a component of the cytoskeleton, found throughout the cytoplasm.These highly dynamic tubular tubulin polymers have an average length of 25 m and a maximum growth length of 50 micrometers. A microtubule has an inner diameter of 12 nm and an outer diameter of about 24 nm. Alpha and beta tubulin combine to form a dimer, which is then polymerized to form microtubules, which are found in eukaryotic cells. One of many members of a small family of globular proteins is tubulin.The alpha-, beta-, gamma-, delta-, and epsilon-tubulins are among the five distinct families that make up the tubulin superfamily, and a sixth family is only found in kinetoplastid protozoa. The proteins that make up microtubules, -tubulin and -tubulin, are the most prevalent members of the tubulin family. Microtubules play a crucial role in many cellular processes. They assist in keeping the cell's structure intact.
Structure | Cat No. | Product Name | CAS No. | Product Description |
---|---|---|---|---|
V22543 | Indibulin | 204205-90-3 | Indibulin is a synthetic small molecule with antimitotic and potential antineoplastic activities. | |
V3514 | Ixabepilone | 219989-84-1 | Ixabepilone (formerly known as azaepothilone B and BMS-247550; Trade name: Ixempra)is a potent and orally bioavailable microtubule-stabilizing agent for the treatment of cancer. | |
V79177 | KGP591 | KGP591 is a tubulin polymerization inhibitor (IC50 0.57µM). | ||
V53033 | KIF18A-IN-1 | 2600559-12-2 | KIF18A-IN-1 is an inhibitor (blocker/antagonist) of the mitotic kinesin KIF18A and has anti-tumor activity. | |
V51902 | KIF18A-IN-6 | 2914879-10-8 | KIF18A-IN-6 (Compound 134) is an orally bioactive KIF18A inhibitor that can suppress KIF18A microtubule-dependent ATPase activity with IC50 of 0.016 μM. | |
V51901 | KIF18A-IN-7 | 2914878-00-3 | KIF18A-IN-7 (Compound 22) is an orally bioactive KIF18A inhibitor that can suppress KIF18A microtubule-dependent ATPase activity with IC50 of 9.4 nM. | |
V24428 | LP-261 | 915412-67-8 | LP-261 is a novel and potent mitotic/tubulin inhibitor with potential anticaner activities. | |
V51814 | MAP4343 | 511-26-2 | MAP4343 is the 3-methyl ether analogue of Pregnenolone. | |
V25075 | Maytansine | 35846-53-8 | Maytansine (maitansine; NSC153858) is a cytotoxic antitubulin agent and an ansamycin antibiotic originally isolated from the Ethiopian shrub Maytenus serrata. | |
V6371 | Maytansinol | 57103-68-1 | Maytansinol (formerly also known as NSC-239386; Ansamitocin P-0), is a potent and natural microtubule depolymerizing agent or antimitotic agent with anticancer activity. | |
V4654 | Mc-MMAE | 863971-24-8 | Mc-MMAE is a novel protective group for MMAE [(maleimidocaproyl)-conjugated monomethyl auristatin E], which is a highly potent mitotic/tubulininhibitor, and is a toxin payload/warhead in antibody drug conjugate (ADC). | |
V75824 | Microtubule destabilizing agent-1 | 2850370-28-2 | Microtubule destabilizing agent-1 (Compound 12b) is a hydroxamic acid-based microtubule destabilizing agent (MDA). | |
V77772 | Microtubule stabilizing agent-1 | Microtubule stabilizing agent-1 (compound 3l) is a paclitaxel analogue that can effectively promote tubulin polymerization. | ||
V5178 | MMAD | 203849-91-6 | MMAD (also known as Monomethyl auristatin D), anauristatin analog, is a novel and highly potent tubulin inhibitor/antimitotic agent that is often used as a warhead or a toxin payload in antibody drug conjugates (ADCs). | |
V76759 | MMAD-d8 (Demethyldolastatin 10-d8; Monomethylauristatin D-d8; Monomethyl Dolastatin 10-d8) | MMAD-d8D is the deuterated form of MMAD. | ||
V19682 | MMAF (Monomethyl auristatin F) | 745017-94-1 | Monomethyl auristatin F (also known as MMAF) is a highly potent tubulin/antimitotic inhibitor and an antineoplastic agent used as a warhead in ADCs (antibody-drug conjugates) such as vorsetuzumab mafodotin and SGN-CD19A. | |
V32943 | MMAF Hydrochloride | 1415246-68-2 | Monomethyl auristatin F (MMAF) HCl is a highly potent tubulin inhibitor and an antineoplastic agent used as a warhead in ADCs (antibody-drug conjugates) such as vorsetuzumab mafodotin and SGN-CD19A. | |
V32229 | MMAF sodium | 1799706-65-2 | Monomethyl auristatin F (MMAF) sodium is a highly potent tubulin inhibitor and an antineoplastic agent used as a warhead in ADCs (antibody-drug conjugates) such as vorsetuzumab mafodotin and SGN-CD19A. | |
V80793 | MMAF-d8 (Monomethylauristatin F D8) | D8-MMAF HCl is the deuterated form of MMAF HCl. | ||
V76758 | MMAF-d8 hydrochloride | MMAF-d8 (HCl)e is the deuterium labelled form of MMAF HCl. |