Aurora Kinase

Aurora Kinase

The Aurora kinases comprise a family of evolutionary conserved serine/threonine kinases (Aurora-A, Aurora-B, and Aurora-C).Aurora kinases regulate a variety of cell cycle-related processes and are necessary for the assembly and operation of the bipolar spindle during the mitotic and meiotic phases.

While Aurora-A, Aurora-B, and Aurora-C have very similar subcellular localizations and functions during mitosis, they also share a highly conserved kinase domain. While Aurora-B and Aurora-C are necessary for condensation, attachment to kinetochores, and alignment of chromosomes during (pro-)metaphase and cytokinesis, Aurora-A primarily regulates centrosome maturation and bipolar spindle assembly. All Aurora kinase members play oncogenic roles related to their mitotic activity and support the survival and growth of cancer cells in human tumors. Researchers studying cancer have become interested in inhibitors that target Aurora kinases.

Aurora Kinase related products

Structure Cat No. Product Name CAS No. Product Description
V73175 YM-08 812647-88-4 YM-08 (Compounds 7a) is an inhibitor (blocker/antagonist) of SIRT2 that can penetrate the BBB (blood-brain barrier), with IC50 of 19.9 μM.
Contact Us Back to top