Insulin receptor (IR), a phylogenetically ancient tyrosine kinase receptor, is a large cell surface glycoprotein that concentrates insulin at the site of action and also initiates responses to insulin.A disulfide-linked oligomer of two alpha and two beta subunits makes up the receptor. The two insulin receptor isoforms, IR-A and IR-B, are present and expressed in various organs and tissues in varying amounts. The binding affinities of the two IR isoforms for insulin and the insulin-like growth factor (IGF)-2 and proinsulin, which are bound by IR-A but not IR-B, are comparable.
Controlling glucose homeostasis, regulating lipid, protein, and carbohydrate metabolism, and modifying levels of brain neurotransmitters are all important functions of the insulin receptor. Diabetes, cancer, and Alzheimer's disease are just a few of the illnesses that have been linked to insulin receptor dysfunction.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V69513 | Insulin degludec | 844439-96-9 | Insulin degludec is an ultra-long-acting form of insulin used to study the hyperglycemia caused by type 1 and type 2 diabetes. |
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V69524 | Insulin efsitora alfa (LY-3209590) | 2131038-11-2 | Insulin efsitora alfa (LY-3209590) is a selective agonist of the insulin receptor (IR). |
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V69517 | Insulin glulisine (HMR 1964) | 207748-29-6 | Insulin glulisine (HMR 1964) is a rapid-acting insulin analogue that mimics the pharmacokinetic and pharmacodynamic characteristics of human physiological insulin. |
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V51123 | Insulin icodec | 1188379-43-2 | insulin analog |
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V69528 | Insulin peglispro (BIL) | 1200440-65-8 | Insulin peglispro (BIL) is a basal insulin with a flat, prolonged activity profile. |
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V12306 | Lespenefril (Kaempferitrin) | 482-38-2 | Lespenefril is a novel and potent agent of antioxidant, antimicrobial and anti-inflammatory. |
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V69516 | MID-1 | 312608-54-1 | MID-1 is an inhibitor (blocker/antagonist) of MG53-IRS-1 (Mitsugumin 53-insulin receptor substrate 1) interaction. |
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V1940 | MSDC-0160 (Mitoglitazone; CAY-10415) | 146062-49-9 | Mitoglitazone (MSDC-0160; CAY10415), a thiazolidinedione analog,is the prototypical mTOT(mitochondrial target of thiazolidinediones)-modulating insulin sensitizer being investigated to treat diabetes and Alzheimers disease. |
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V81000 | OI338 | OI338 is an oral, long-acting insulin analog. | |
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V32306 | Rhoifolin | 17306-46-6 | Rhoifolin is a flavonoid glycoside that can be extracted from wild lacquer. |
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V69521 | S961 | 1083433-49-1 | S961 is a high-affinity insulin receptor (IR) antagonist (inhibitor) with IC50s of 0.048, 0.027 and 630 for HIR-A, HIR-B and human insulin-like growth factor I receptor (HIGF-IR) respectively. |
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V76543 | S961 acetate | S961 acetate is a high-affinity insulin receptor (IR) antagonist (inhibitor) with IC50s of 0.048, 0.027 and 0.027 for HIR-A, HIR-B and human insulin-like growth factor I receptor (HIGF-IR) respectively. | |
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V76542 | S961 TFA | S961 TFA is a high-affinity insulin receptor (IR) antagonist (inhibitor) with IC50s of 0.048, 0.027 and 0.027 for HIR-A, HIR-B and human insulin-like growth factor I receptor (HIGF-IR) respectively. | |
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V69515 | Valanafusp alfa (AGT-181; HIRMAb-IDUA) | 1815583-32-4 | Valanafusp alfa (AGT-181) is a brain-penetrating recombinant fusion protein of a chimeric monoclonal antibody (mAb) against human insulin receptor (HIR) and human sulfosidase (IDUA). |
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