Estrogen receptors are a group of proteins found inside cells.They are receptors that the estrogen (17-estradiol) hormone activates. There are two classes of estrogen receptors: GPER (GPR30), a member of the rhodopsin-like family of G protein-coupled receptors, and ER, a member of the nuclear hormone family of intracellular receptors. The interactions between coactivators and corepressors, and consequently, the agonist or antagonist effect of the ligand, are heavily influenced by the ER's helix 12 domain.Different ligands may have different affinities for the estrogen receptor's alpha and beta isoforms. Estradiol binds to both receptors equally well, however raloxifene, estrone, and genistein bind preferentially to the alpha receptor. In addition to being necessary for sexual maturation and reproductive function, estrogen and its receptors also affect other tissues, like bone. In pathological conditions like osteoporosis, endometrial cancer, and breast cancer, estrogen receptors play a role. Numerous transcript variations are produced by alternative promoter use and alternative splicing, however it is unknown how many of these variants are full-length.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V67676 | Diethylstilbestrol-d8 (Stilbestrol-d8) | 91318-10-4 | Diethylstilbestrol-d8 is the deuterium labelled form of Diethylstilbestrol. |
|
V20253 | Droloxifene (3-Hydroxytamoxifen) | 82413-20-5 | Droloxifene (3-Hydroxytamoxifen) is a tamoxifen analogue and orally bioactive SERM (selective estrogen receptor modulator) that acts as an ER agonist in bone and as an ER antagonist in breast tissue. |
|
V67724 | DS20362725 | 2735803-20-8 | DS20362725 is an estrogen-related receptor alpha (ERRα) agonist. |
|
V67723 | DS45500853 | 2735803-28-6 | DS45500853 is an estrogen-related receptor alpha (ERRα) agonist. |
|
V2996 | DY131 | 95167-41-2 | DY131 (also known as GSK-9089) is a novel selective agonist at estrogen-related receptors ERRβ and ERRγ with minimal activity at ERRα, ERα and ERβ at concentrations up to 30 μM. |
|
V4061 | E3 ligase Ligand 5 | 1264754-13-3 | E3 ligase Ligand 5 is an E3 ligase Ligand that can be used in the synthesis of PROTACs (proteolysis targeting chimeras) to engage an E3 ubiquitin ligase. |
|
V67660 | Elacestrant (S enantiomer) (RAD1901 S enantiomer) | 2309762-29-4 | Elacestrant S enantiomer (RAD1901 S enantiomer) is the less active enantiomer of Elacestrant. |
|
V67663 | Elacestrant S enantiomer dihydrochloride (RAD1901 S enantiomer dihydrochloride) | 2309762-30-7 | Elacestrant S enantiomer di-HCl (RAD1901 S enantiomer di-HCl) is the less active enantiomer of Elacestrant. |
|
V19199 | Enclomiphene citrate | 7599-79-3 | Enclomiphene citrate, formerly known as ICI-46476, RMI-16289 and trans-Clomiphene, is an orally bioavailable non-steroidal estrogen receptor antagonist in development for secondary hypogonadism in overweight men wishing to restore normal testicular function. |
|
V33910 | Endoxifen | 110025-28-0 | Endoxifen, an active metabolite of Tamoxifen, is a potent and selective estrogen receptor antagonist and has been found to be effective in patients that have failed previous hormonal therapies. |
|
V20552 | Endoxifen E-isomer HCl | 1197194-61-8 | Endoxifen E-isomer HCl (E-Endoxifen HCl) is the E-isomer of Endoxifen and is the main impurity in the raw material of Endoxifen Z-isomer. |
|
V5719 | Endoxifen Z-isomer | 112093-28-4 | Endoxifen Z-isomer is an active metabolite of Tamoxifen metabolite responsible for eliciting the anti-estrogenic effects of this drug in breast cancer cells expressing estrogen receptor-alpha (ERα). |
|
V30482 | Equilin (7-Dehydroestrone) | 474-86-2 | Equilin (7-Dehydroestrone) is an important member of a large family of estrogenic substances that is chemically related to estradiol. |
|
V67703 | Equilin-d4 (7-Dehydroestrone-d4) | 285979-79-5 | Equilin-d4 is the deuterium labelled form of Equilin. |
|
V28146 | Equol (racemic) | 94105-90-5 | Equol (racemic), the racemic mixture of equol,is a drug is potentially for the treatment of acute thyroid disease and inhibits proliferation of human gastric carcinoma cells. |
|
V67678 | ER degrader 4 | 2913192-39-7 | ER degrader 4 is a selective and orally bioactive estrogen receptor degrader. |
|
V67679 | ER degrader 5 | 2913192-47-7 | ER degrader 5 is a potent estrogen receptor (ER) degrader. |
|
V67712 | ER degrader 6 | 2922929-62-0 | ER degrader 6 (compound 35s) is a potent estrogen receptor (ER) alpha degrader. |
|
V67721 | ERRα antagonist-1 | 1072145-33-5 | ERRα antagonist-1 (Compound A) is a selective, high-affinity estrogen-related receptor α (ERRα) antagonist. |
|
V67719 | ERRγ inverse agonist 1 | 2316832-86-5 | ERRγ Inverse Agonist 1 (Compound 12) is a specific, orally bioactive estrogen-related receptor gamma (ERRγ) inverse agonist/activator with IC50 of 40 nM. |
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