Mitochondria use multiple carbon fuels to produce ATP and metabolites, including pyruvate, which is generated from glycolysis; amino acids such as glutamine; and fatty acids. The reducing equivalents NADH and FADH2, which transfer their electrons to the electron transport chain, are produced by these carbon fuels by feeding into the TCA cycle in the mitochondrial matrix. Complex organelles called mitochondria are crucial for many aspects of cellular function, including metabolism, immune control, and cell death.Calcium buffering, lipid flux, and intracellular signaling are just a few of the many cellular processes and molecular interactions that mitochondria actively participate in. It is becoming more widely acknowledged that mitochondrial dysfunction is a defining feature of many diseases, including cancer, cardiovascular, and neurodegenerative conditions. Mitochondrial metabolism influences processes like the epithelial-to-mesenchymal transition, which is a key factor in the progression of tumors. The epigenetic landscape is altered by mitochondrial metabolism and the oncometabolites that result to change the aggressiveness characteristics of cancer cells. Regarding the survival of tumors in response to treatment, changes in mitochondrial metabolism are important.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V73216 | SCAL-266 | 2798953-78-1 | SCAL-266 is a potent mitochondrial complex I (CI) inhibitor (antagonist) with IC50 of 0.83 μM. |
|
V73211 | Senecionine acetate (O-Acetylsenecionine) | 126642-77-1 | Senecionine acetate (O-Acetylsenecionine) is a pyrrolidine core alkaloid. |
|
V73202 | SH-BC-893 | 1841409-92-4 | SH-BC-893 is an antitumor sphingolipid analog with oral activity. |
|
V73201 | T0467 | 859518-94-8 | T0467 activates mitochondrial parkin translocation in a PINK1-dependent manner. |
|
V5050 | Vatiquinone (EPI743) | 1213269-98-7 | Vatiquinone (formerly also known as EPI-743) is anovel, potent and orally bioavailable cellular oxidative stress protectant and a para-benzoquinone analog being developed for treating inherited mitochondrial diseases. |
|
V79937 | ZK53 | ZK53 is a selective activator of mitochondrial caseinolytic protease P (HsClpP) (EC50 for HsClpP hydrolysis of α-casein: 1.37 μM). |
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