1. Home
  2. Products
  3. Signaling Pathways
  4. Apoptosis
  5. Apoptosis

Apoptosis

Apoptosis

Cell membrane blebbing, chromatin condensation, genomic DNA fragmentation, and the exposure of particular phagocytosis signaling molecules on the cell surface are just a few of the distinctive morphological and biochemical features of the cell death process known as apoptosis. Apoptosis-initiated cell death is distinct from necrosis-induced cell death. Apoptotic death, in contrast, is silent and orderly. Necrotic cells are typically recognized as a danger signal by the immune system, which causes inflammation.

There are two main methods for inducing apoptotic cell death: The intrinsic pathway, also known as the Bcl-2-regulated or mitochondrial pathway, is strictly regulated by the BCL-2 family of proteins and is activated by a variety of developmental cues or cytotoxic insults, such as viral infection, DNA damage, and growth-factor deprivation.The tumor necrosis factor (TNF) receptor family members, such as Fas or TNF receptor-1 (TNFR1), which contain an intracellular death domain and can recruit and activate caspase-8 through the adaptor protein Fas-associated death domain (FADD; also known as MORT1) at the cell surface, are what initiate the extrinsic or death-receptor pathway. Without the involvement of the BCL-2 family, this recruitment results in the subsequent activation of downstream (effector) caspases like caspase-3, -6, or -7.

Numerous human diseases, including cancer, viral infections, autoimmune diseases, neurodegenerative disorders, and AIDS (acquired immunodeficiency syndrome), may be influenced by changes in cell survival, according to studies. Some of these diseases may not progress naturally unless specific therapies that change the apoptotic threshold are used.

Apoptosis related products

Structure Cat No. Product Name CAS No. Product Description
V34832 Anti-inflammatory agent 35 2293951-00-3 Anti-inflammatory agent 35 (compound 5a27) is an orally bioavailable curcumin analog with anti-inflammatory activity.
V34831 Anti-inflammatory agent 41 2896204-90-1 Anti-inflammatory agent 41 (13a) significantly inhibited lipopolysaccharide (LPS)-induced expression of pro-inflammatory cytokines IL-6 and TNF-α in J774A.
V78935 Anti-inflammatory agent 45 Anti-inflammatory agent 45 (compound 2v) is an anticancer agent with direct inhibitory effects on the growth of different blood cancers such as leukemia, lymphoma and myeloma cell lines.
V35026 Anti-inflammatory agent 47 2925288-12-4 Flo8 is a potent anti-inflammatory and antioxidant compound.
V55012 Anti-inflammatory agent 54 2924156-46-5 Anti-inflammatory agent 54 (compound 9c) is an analogue of Coixol and exhibits anti-inflammatory effect.
V55013 Anti-inflammatory agent 55 2924156-51-2 Anti-inflammatory agent 55 (compound 9j) is an analogue of Coixol and exhibits anti-inflammatory effect.
V52410 anti-TNBC agent-1 2289585-58-4 anti-TNBC agent-1 is a potent anti-triple-negative breast cancer (TNBC) agent.
V56387 anti-TNBC agent-2 2422001-22-5 anti-TNBC agent-2 (3j) is a purine analogue against triple-negative breast cancer (TNBC).
V35002 anti-TNBC agent-3 2422001-25-8 anti-TNBC agent-3 (compound 3g) is an apoptosis inducer with anti-cancer cell proliferation/growth activity.
V34835 Antibiotic DC 81 (DC 81) 81307-24-6 Antibiotic DC 81 (DC 81) is an antitumor antibiotic produced by Streptomyces species and is a pyrrole[2,1-c][1,4]benzodiazepine (PBD).
V34997 Anticancer agent 102 2914922-86-2 anti-cancer compound 102 is an analogue of tetracaine.
V77924 Anticancer agent 104 anti-cancer compound 104 has anti-cancer effect and causes apoptosis in cancer/tumor cells.
V35001 Anticancer agent 105 2450987-57-0 Anticancer agent 105 is a thienopyrimidine scaffold-based compound with good safety and anticancer properties.
V78810 Anticancer agent 106 Anticancer agent 106 (compound 10ic) is an anticancer agent that causes apoptosis in B16-F10 melanoma cells.
V35000 Anticancer agent 110 887349-03-3 Anticancer agent 110 is an anticancer agent with in vitro anti-cancer activity as well as excellent antileukemic potency.
V34999 Anticancer agent 118 864443-43-6 Anticancer agent 118 is an N-acylated ciprofloxacin analogue with antibacterial and anticancer activities.
V54851 Anticancer agent 119 2928614-16-6 Anticancer agent 119 (compound 15) is an N-acylated ciprofloxacin analogue that has certain anti-bacterial effect and can induce the production of ROS to induce apoptosis of cancer cells.
V53845 Anticancer agent 120 2928614-22-4 Anticancer agent 120 (compound 21) is an N-acylated ciprofloxacin analogue that has certain anti-bacterial effect and can induce the production of ROS to induce apoptosis of cancer cells.
V54971 Anticancer agent 128 2941243-62-3 Anticancer agent 128 (compound 1) is an IAP inhibitor that covalently targets the BIR3 domain of XIAP, cIAP1, and cIAP2.
V77982 Anticancer agent 130 anti-cancer compound 130 (compound 8d) is an anti-cancer compound that can significantly cause apoptosis in A549 cells.
Contact Us
Tel: 1-708-310-1919 Fax: 1-708-557-7486 Email: sales@invivochem.com Frequently Asked Questions
Subscribe to our E-newsletter
Name
E-mail

Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved

Contact Us Back to top
Home Classify Cart Member