Cell membrane blebbing, chromatin condensation, genomic DNA fragmentation, and the exposure of particular phagocytosis signaling molecules on the cell surface are just a few of the distinctive morphological and biochemical features of the cell death process known as apoptosis. Apoptosis-initiated cell death is distinct from necrosis-induced cell death. Apoptotic death, in contrast, is silent and orderly. Necrotic cells are typically recognized as a danger signal by the immune system, which causes inflammation.
There are two main methods for inducing apoptotic cell death: The intrinsic pathway, also known as the Bcl-2-regulated or mitochondrial pathway, is strictly regulated by the BCL-2 family of proteins and is activated by a variety of developmental cues or cytotoxic insults, such as viral infection, DNA damage, and growth-factor deprivation.The tumor necrosis factor (TNF) receptor family members, such as Fas or TNF receptor-1 (TNFR1), which contain an intracellular death domain and can recruit and activate caspase-8 through the adaptor protein Fas-associated death domain (FADD; also known as MORT1) at the cell surface, are what initiate the extrinsic or death-receptor pathway. Without the involvement of the BCL-2 family, this recruitment results in the subsequent activation of downstream (effector) caspases like caspase-3, -6, or -7.
Numerous human diseases, including cancer, viral infections, autoimmune diseases, neurodegenerative disorders, and AIDS (acquired immunodeficiency syndrome), may be influenced by changes in cell survival, according to studies. Some of these diseases may not progress naturally unless specific therapies that change the apoptotic threshold are used.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V53406 | AKT-IN-3 | 2374740-21-1 | AKT-IN-3 (compound E22) is a potent, oral, low-hERG-blocking Akt inhibitor (antagonist) with IC50s of 1.4 nM, 1.2 nM, and 1.7 nM for Akt1, Akt2, and Akt3, respectively. |
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V52433 | AlbA-DCA | 2413716-79-5 | AlbA-DCA is a conjugate formed by linking Albiziabioside A (AlbA) to the dichloroacetic acid (DCA) subunit. |
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V52432 | Albanol B | 87084-99-9 | Albanol B is an arylbenzofuran analogue extracted from mulberries. |
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V52429 | Alisertib sodium (MLN 8237 sodium) | 1028486-06-7 | Aliertib (MLN 8237) sodium is an orally bioactive and selective Aurora A kinase inhibitor (IC50=1.2 nM). |
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V52428 | Alisol F 24-acetate | 443683-76-9 | Alisol F 24-acetate is a triterpene compound extracted from the rhizome of Alisma orientalis. |
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V54834 | ALK/EGFR-IN-1 | 2730430-08-5 | ALK/EGFR-IN-1 (Compound 8l) is an ALK/EGFR dual (bifunctional) inhibitor that blocks the phosphorylation of EGFR and ALK. |
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V55022 | Aloeresin G | 287486-23-1 | Aloeresin G is a chromone glycoside that can be extracted from Aloe. |
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V56450 | Alogliptin-d3 (SYR-322-d3 (free base)) | 1133421-35-8 | Alogliptin-d3 is the deuterium labelled form of Alogliptin. |
|
V52615 | Amantadine-d15 (1-Adamantanamine-d15; 1-Aminoadamantane-d15) | 33830-10-3 | Amantadine-d15 is the deuterated form of Amantadine. |
|
V52614 | Amantadine-d6 (1-Adamantanamine-d6; 1-Aminoadamantane-d6) | 1219805-53-4 | Amantadine-d6 is the deuterated form of Amantadine. |
|
V52555 | Amiloride-15N3 hydrochloride (MK-870-15N3 hydrochloride) | 1216796-18-7 | Amiloride-15N3 ( HCl) is the deuterated form of Amiloride HCl. |
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V77934 | Amoxetamide A | Amoxetamide A is an anoikis inducer and displays anoikis-inducing activity on human colorectal cancer HT-29 cells. | |
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V77265 | AMXT-1501 tetrahydrochloride | AMXT-1501 tetra HCl is an orally bioactive polyamine transport inhibitor. | |
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V35054 | Amyloid 17-42 (Aβ(17-42)) | 155178-13-5 | Amyloid 17-42 (Aβ(17-42)) is the major component of precerebellar amyloid in diffuse plaques in AD/Alzheimer's disease and Down syndrome, consisting of the alpha and gamma amyloid precursor protein (APP). |
|
V30297 | Angelicin (Isopsoralen) | 523-50-2 | Angelicin is a naturally occurring tricyclic aromatic hydrocarbon compound that is structurally related to psoralen and has anti-cancer, anti~inflammatory, anti-viral and other activities. |
|
V34683 | Angiotensin II human acetate (Angiotensin II acetate; Ang II acetate; DRVYIHPF acetate) | 68521-88-0 | Angiotensin II human (Angiotensin II) acetate is a vasoconstrictor and the major biologically active peptide of the renin/angiotensin system. |
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V34766 | Angiotensin II human TFA (Angiotensin II TFA; Ang II TFA; DRVYIHPF TFA) | 2761969-44-0 | Angiotensin II human (Angiotensin II) TFA is a vasoconstrictor and the major biologically active peptide of the renin/angiotensin system. |
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V54825 | Angophorol | 133442-54-3 | Angophorol is a flavonoid compound. |
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V56462 | Antcin A | 163597-24-8 | Antcin A is an NLRP3 inhibitor that can suppress the assembly and activation of the NLRP3 inflammasome. |
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V52413 | Anti-CSCs agent-1 | 2251753-58-7 | Anti-CSCs agent-1 is an effective anti-CSCs agent. |
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