Synuclein is a protein that is found in abundance in neurons and is particularly enriched in presynaptic nerve terminals. Synaptic vesicle trafficking and ensuing neurotransmitter release are controlled by -synuclein. -synuclein has been linked to Parkinson's disease (PD) and other neurodegenerative diseases through genetic and neuropathology research. Multiple neurodegenerative diseases known as synucleinopathies are characterized by the accumulation of misfolded oligomers and larger aggregates of -synuclein, but the mechanisms by which -synuclein acts in neurodegeneration are unknown.
Structure | Cat No. | Product Name | CAS No. | Product Description |
---|---|---|---|---|
V70177 | α-Synuclein (71-82) (human) | 332867-16-0 | α-Synuclein (71-82) (human) is the 71-82 fragment of α-Synuclein. | |
V70178 | α-Synuclein 4554W | 2243207-00-1 | α-Synuclein 4554W is an α-Synuclein (aSyn) aggregation inhibitor (antagonist) with associated toxicity. | |
V70185 | α-Synuclein inhibitor 8 | 2883627-64-1 | α-Synuclein inhibitor 8 is a potent α-Synuclein inhibitor (antagonist) with IC50 of 2.5 µM. | |
V70182 | α-Synuclein inhibitor 9 | 1510825-03-2 | α-Synuclein inhibitor 9 (Compound 20C) is an α-Synuclein inhibitor. |