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Beta Amyloid

Beta Amyloid

As the primary component of the amyloid plaques seen in the brains of Alzheimer patients, amyloid- (A) refers to peptides of 36–43 amino acids that are crucially involved in Alzheimer's disease. The amyloid precursor protein (APP), which is cut by specific enzymes to produce A, produces the peptides. Amyloid molecules can group together to create a variety of flexible, soluble oligomers.A amyloid-peptide buildup results from excessive A production or malfunctioning clearance mechanisms. Amyloid- forms diffuse and neuritic plaques in the parenchyma and blood vessels by self-aggregating into oligomers of various sizes. Strong synaptotoxins, proteasome inhibition, mitochondrial inhibition, alteration of intracellular Ca2+ levels, and induction of inflammatory processes are all characteristics of amyloid-oligomers and plaques. Neuronal dysfunction is also thought to be influenced by the loss of A's typical physiological functions.

Beta Amyloid related products

Structure Cat No. Product Name CAS No. Product Description
β-Amyloid (40-1) V71422 β-Amyloid (40-1) 144409-99-4 β-Amyloid (40-1) is a biologically active peptide.
β-Amyloid peptide(16-20) (KLVFF) V71364 β-Amyloid peptide(16-20) (KLVFF) 153247-40-6 β-Amyloid peptide(16-20) is an amino acid (AA) sequence (KLVFF) of Amyloid-β (Abeta).
β-Amyloid-15N (1-40) (TFA) (Amyloid Beta-Peptide-15N (1-40) (human) TFA; Amyloid β-Peptide-15N (1-40) (human) TFA) V81810 β-Amyloid-15N (1-40) (TFA) (Amyloid Beta-Peptide-15N (1-40) (human) TFA; Amyloid β-Peptide-15N (1-40) (human) TFA) β-Amyloid-15N (1-40) (TFA) is 15N (Nitrogen 15)-labelled β-Amyloid (1-40) (TFA).
β-Amyloid-15N (1-42), human TFA (Amyloid β-peptide-15N (1-42) (human) TFA) V81811 β-Amyloid-15N (1-42), human TFA (Amyloid β-peptide-15N (1-42) (human) TFA) β-Amyloid-15N (1-42), human (TFA) is 15N (Nitrogen 15)-labelled β-Amyloid (1-42) (TFA).
β-Sheet Breaker Peptide iAβ5 ([Pro18, Asp21] β-Amyloid (17-21)) V71366 β-Sheet Breaker Peptide iAβ5 ([Pro18, Asp21] β-Amyloid (17-21)) 182912-74-9 Beta-Sheet Breaker Peptide iAβ5 is a potent brain amyloid-beta (Abeta) degrader.
γ-Secretase modulator 13 V71407 γ-Secretase modulator 13 1353570-40-7 γ-Secretase modulator 13 (compound 4) is a γ-secretase modulator (GSMs) that can inhibit the production of aggregated amyloid β peptide Aβ42 with IC50 of 163 nM, may be utilized in AD/Alzheimer's disease study.
京尼平甙 V21547 Geniposide 24512-63-8 Geniposide is an iridoid glycoside found in gardenia flowers; possesses diverse biological effects like antidiabetic, antioxidant, antiproliferation, and neuro-protective (neuro-protection) activities.
它波宁 V9037 Tabersonine 4429-63-4 Tabersonine is a naturally occuring terpene indole alkaloid extracted from the medicinal plant Catharanthus roseus and also in the genus Voacanga.
甘草查耳酮B V24107 Licochalcone B 58749-23-8 Licochalcone B,a naturally occuring chalcone compound isolated from the root ofGlycyrrhiza inflate, is an inhibitor of phosphorylation of NF-kappaB p65 in LPS signaling pathway.
甲磺酸去铁胺 V15809 Deferoxamine mesylate 138-14-7 Deferoxamine is an novel iron chelator that is able to bind to free iron in a stable complex, it is also a bacterial siderophore produced by the Actinobacteria Streptomyces pilosus.
羟丙基环胡精 V33327 (2-Hydroxypropyl)-β-cyclodextrin 128446-35-5 2-Hydroxypropyl)-β-cyclodextrin is a cyclodextrin oligosaccharide that has beenwidely used drug delivery vehicle to improve the aqueous solubility,stability and bioavailability of chemical compounds.
苏木精 V2021 Hematoxylin (Haematoxylin) 517-28-2 Hematoxylin (also known as Hydroxybrazilin; Natural Black 1) is a natural compound that forms strongly colored complexes with certain metal ions, notably Fe(III) and Al(III) salts and a kind of stain in histology.
补骨脂二氢黄酮甲醚 V4468 Bavachinin (BVC; 7-O-Methylbavachin; Bavachinin A) 19879-30-2 Bavachinin(BVC; 7-O-Methylbavachin; Bavachinin A) is a naturally occuring compound isolated from the fruit of the traditional Chinese herb Fructus Psoraleae (FP).
赫斯特荧光染料 34580 V31301 Hoechst 34580 (HOE 34580) 23555-00-2 Hoechst 34580 is a marking dye from the Hoechst range.
阿齐瑞格 V2883 Azeliragon (TTP488; PF-04494700) 603148-36-3 Azeliragon (also known as TTP488 and PF-04494700) is a potent and orally bioavailable RAGE (Receptor for Advanced Glycation End products) inhibitor that has the potential for the treatment ofmild-to-moderate Alzheimers disease and cerebral amyloid angiopathy.
马来酸盐艾多奈匹 V20400 Edonerpic maleate 519187-97-4 Edonerpic, formerly known as T-817, is a neuroprotectant.
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