Opioid ligands are a class of G protein-coupled receptors known as opioid receptors. Dynorphins, enkephalins, endorphins, endomorphins, and nociceptin are examples of endogenous opioids. There are many opioid receptors in the brain, as well as in the spinal cord and digestive system. The body has molecules or sites called opioid receptors that are triggered by opioid substances. Opioid receptors prevent impulses from traveling along excitatory pathways in the human body.The serotonin, catecholamine, and substance P pathways are some of these pathways, and they are all thought to play a role in pain perception and feelings of wellbeing. Mu, delta, and kappa receptors are additional subclassifications of opioid receptors. While each class has its own unique way of acting, they all have some fundamental things in common. The potassium pump mechanism, which is present on the plasma membrane of most cells, powers them all.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V69971 | Naltrexone-d4 (naltrexone D4) | 2070009-29-7 | Naltrexone-d4 is the deuterium labelled form of Naltrexone. |
|
V78367 | NAQ | NAQ is a potent and specific partial agonist of the mu-opioid receptor with a Ki of 0.55 nM. | |
|
V1274 | Nitrendipine (BAY-E-5009) | 39562-70-4 | Nitrendipine (BAY-E5009; BAY E-5009; Bayotensin; Bayotensin, Baypress, Nidrel, Deiten) is a potent dihydropyridine (DHP) calcium channel blocker (CCB) with antihypertensive effects. |
|
V76693 | Nociceptin (1-13), amide TFA | Nociceptin (1-13), amide TFA is a potent opioid receptor ORL1 (OP4) receptor agonist/activator with pEC50 of 7.9 for mouse vas deferens and a Ki of 0.75 nM for rat forebrain membrane binding. | |
|
V69968 | Nociceptin(1-7) | 178249-42-8 | Nociceptin(1-7) is the N-terminal bioactive fragment of Nociceptin. |
|
V80961 | Nociceptin(1-7) TFA | Nociceptin(1-7) is the N-terminal bioactive fragment of Nociceptin. | |
|
V69956 | Nocistatin | 207392-60-7 | Nocistatin is a neuropeptide and endogenous ligand for orphan opioid receptors. |
|
V86057 | NOP agonist-1 | 2099681-43-1 | |
|
V84962 | NOP agonist-2 | 2099680-36-9 | |
|
V69929 | O-Desmethyl Tramadol-d6 | 873928-73-5 | O-Desmethyl Tramadol-d6 is the deuterated form of O-Desmethyl Tramadol. |
|
V69959 | Orphanin FQ(1-11) | 178249-41-7 | Orphanin FQ(1-11), an orphan protein FQ or nociceptin (OFQ/N) fragment, is a potent NOP (ORL-1; OP4) receptor agonist/activator with a Ki of 55 nM. |
|
V81014 | Orphanin FQ(1-11) TFA | Orphanin FQ(1-11) TFA, an orphan protein FQ or nociceptin (OFQ/N) fragment, is a potent NOP receptor (ORL-1; OP4) agonist/activator with a Ki of 55 nM. | |
|
V69974 | Picraline | 2671-32-1 | Picraline is a naturally occurring alkaloid that targets opioid receptors. |
|
V83654 | PIPE-3297 | ||
|
V81164 | PL-017 TFA | PL-017 TFA is a specific μ opioid receptor agonist/activator with IC50 of 5.5 nM for 125I-FK 33,824 binding to the μ site. | |
|
V29494 | Porcine dynorphin A(1-13) | 72957-38-1 | Porcine dynorphin A (1-13) is a potent endogenous κ opioid receptor agonist (activator) that relieves pain at physiological concentrations. |
|
V8817 | PZM21 | 1997387-43-5 | PZM21 is a novel, potent and selective Gi activator with exceptional selectivity for μ opioid receptor (μOR) and minimal β-arrestin-2 recruitment with an EC50 of 1.8 nM. |
|
V1278 | Racecadotril (acetorphan) | 81110-73-8 | Racecadotril (also called acetorphan) is a potent and peripherally acting enkephalinase inhibitor used as an antidiarrheal medication. |
|
V69920 | Riminkefon | 2168572-99-2 | Riminkefon is a kappa opioid receptor agonist (activator). |
|
V76529 | SB-612111 hydrochloride | SB-612111 HCl is a new and highly effective opioid receptor orphan receptor (ORL-1) antagonist (inhibitor) with high affinity for hORL-1 (Ki=0.33 nM). |
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