A PROTAC (Proteolysis Targeting Chimeric Molecule) is a protein degrader comprised of a ligand for E3 ligase (E3 ligase binder), a linker and a ligand for target protein (target binder).The transfer of ubiquitin and degradation of the targeted protein will occur as a result of the connection between an E3 ligase and a target protein brought on by a PROTAC.
E3 ligases determine the specificity of the proteins by catalyzing the transfer of ubiquitin to the desired proteins. Cells have hundreds of E3 ligases, but only a small number of them have been successfully exploited in PROTACs, including VHL (the tumor suppressor protein for von Hippel-Lindau disease), CRBN (Cereblon), MDM2 (the mouse double minute 2 homologue), and IAP (inhibitor of apoptosis).
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V82572 | MS-PEG1-THP | 1309248-13-2 | MS-PEG1-THP is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders. |
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V82584 | MS-PEG3-dodecyl | 2148295-99-0 | MS-PEG3-dodecyl is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. |
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V82533 | MS-PEG4-THP | 145927-73-7 | MS-PEG4-THP is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. |
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V80904 | N-Boc-SBP-0636457-OH | N-Boc-SBP-0636457-OH is a ligand for E3 ubiquitin ligase and is used for recruitment of IAP E3 ligase to degrade Bcl-xL. | |
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V75863 | NV03 | 2448341-58-8 | NV03 is a potent and specific antagonist of the interaction between UHRF1 and H3K9me3 with a Kd of 2.4 μM. |
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V51743 | OICR-8268 | OICR-8268 is a reversible DCAF1 ligand that binds to the DCAF1 WDR domain with Kd of 38 nM. | |
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V76613 | Pomalidomide-5-C11-NH2 hydrochloride | Pomalidomide-5-C11-NH2 HCl is a Pomalidomide-based E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit cereblon proteins. | |
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V76612 | Pomalidomide-5-C12-NH2 hydrochloride | Pomalidomide-5-C12-NH2 HCl is a Pomalidomide-based E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit cereblon proteins. | |
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V78713 | Pomalidomide-5-C13-NH2 hydrochloride | Pomalidomide-5-C13-NH2 HCl is a Pomalidomide-based E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit cereblon proteins. | |
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V78537 | Pomalidomide-5-C14-NH2 hydrochloride | Pomalidomide-5-C14-NH2 HCl is a Pomalidomide-based E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit cereblon proteins. | |
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V80120 | Pomalidomide-5-C3-NH2 hydrochloride | Pomalidomide-5-C3-NH2 HCl is a Pomalidomide-based E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit cereblon proteins. | |
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V81170 | Pomalidomide-5-C4-NH2 hydrochloride | Pomalidomide-5-C4-NH2 HCl is a Pomalidomide-based E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit cereblon proteins. | |
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V80004 | Pomalidomide-5-C6-NH2 hydrochloride | Pomalidomide-5-C6-NH2 HCl is a Pomalidomide-based E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit cereblon proteins. | |
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V79810 | Pomalidomide-5-C7-NH2 hydrochloride | Pomalidomide-5-C7-NH2 HCl is a Pomalidomide-based E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit cereblon proteins. | |
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V82580 | Pomalidomide-amino-PEG4-NH2 hydrochloride | 2331259-45-9 | Pomalidomide-amino-PEG4-NH2 HCl is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate, containing Pomalidomide-based cereblon ligand and 1 linker, which may be utilized to prepare PROTAC molecules. |
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V82547 | Pomalidomide-C11-NH2 | 2648285-39-4 | Pomalidomide-C11-NH2 is a Pomalidomide-based E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit cereblon proteins. |
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V82595 | Pomalidomide-C5-Dovitinib | 2732969-67-2 | Pomalidomide-C5-Dovitinib (compound 2) is a PROTAC containing Pomalidomide, Dovitinib linked to CRBN. |
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V81172 | Pomalidomide-PEG7-NH2 hydrochloride | Pomalidomide-PEG7-NH2 HCl is a Pomalidomide-based E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit cereblon proteins. | |
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V82523 | Propargyl-PEG5-PFP ester | 2148295-92-3 | Propargyl-PEG5-PFP ester is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules. |
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V82557 | PROTAC BRD9 Degrader-2 | 2633631-78-2 | PROTAC BRD9 Degrader-2 is a BRD9 bifunctional degrader for cancer research. |
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