Ligands for E3 Ligase

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Ligands for E3 Ligase

A PROTAC (Proteolysis Targeting Chimeric Molecule) is a protein degrader comprised of a ligand for E3 ligase (E3 ligase binder), a linker and a ligand for target protein (target binder).The transfer of ubiquitin and degradation of the targeted protein will occur as a result of the connection between an E3 ligase and a target protein brought on by a PROTAC.

E3 ligases determine the specificity of the proteins by catalyzing the transfer of ubiquitin to the desired proteins. Cells have hundreds of E3 ligases, but only a small number of them have been successfully exploited in PROTACs, including VHL (the tumor suppressor protein for von Hippel-Lindau disease), CRBN (Cereblon), MDM2 (the mouse double minute 2 homologue), and IAP (inhibitor of apoptosis).

Ligands for E3 Ligase related products

Cat No.	Product Name	CAS No.	Product Description
V82575	PROTAC BRD9 Degrader-3	2633632-05-8	PROTAC BRD9 Degrader-3 is a BRD9 bifunctional degrader for cancer research.
V82554	PROTAC CDK9 degrader-4	2411021-01-5	PROTAC CDK9 degrader-4 is a highly efficient, transcriptionally targeted CDK9 degrader.
V82528	PROTAC IRAK4 ligand-3	2434848-46-9	PROTAC IRAK4 ligand-3 is the ligand of PROTAC IRAK4 degrader-7 .
V82579	PROTAC TTK degrader-2	2953426-48-5	PROTAC TTK degrader-2 is a potent TTK (threonine tyrosine kinase) PROTAC degrader with DC50s of 3.1 and 12.4 nM in COLO-205 and HCT-116 cells, respectively.
V82568	S-acetyl-PEG4-amine	1404111-71-2	S-acetyl-PEG4-amine is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82562	SCO-PEG4-COOH	2141976-27-2	SCO-PEG4-COOH is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG category.
V82577	SCO-PEG8-COOH	2143968-79-8	SCO-PEG8-COOH is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG category.
V82582	t-Butyl acetate-PEG3-CH2COOH	1442466-57-0	t-Butyl acetate-PEG3-CH2COOH is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82551	Thalidomide-4-NH-PEG1-COOH TFA	2140807-20-9	Thalidomide-4-NH-PEG1-COOH TFA is a conjugate of E3 ligase ligand and linker consisting of Thalidomide and NH-PEG3-NH-Boc.
V82574	Thalidomide-4-NH-PEG1-NH2 TFA	2490499-21-1	Thalidomide-4-NH-PEG1-NH2 TFA is an E3 ligase (e.g. CRBN) ligand-linker conjugate consisting of Thalidomide nd NH-PEG3-NH-Boc.
V82576	Thalidomide-4-NH-PEG2-COO(t-Bu)	2140807-16-3	Thalidomide-4-NH-PEG2-COO(t-Bu) is a t-Bu modified Thalidomide, which could be utilized as Cereblon ligand to recruit CRBN protein.
V76438	Thalidomide-4-O-C10-NH2 hydrochloride		Thalidomide-4-O-C10-NH2 HCl is a Thalidomide-based cereblon (E3 ligase) ligand that recruits CRBN protein.
V76437	Thalidomide-4-O-C11-NH2 hydrochloride		Thalidomide-4-O-C11-NH2 HCl is a Thalidomide-based cereblon (E3 ligase) ligand that recruits CRBN protein.
V76436	Thalidomide-4-O-C12-NH2 hydrochloride		Thalidomide-4-O-C12-NH2 HCl is a Thalidomide-based cereblon (E3 ligase) ligand that recruits CRBN protein.
V81567	Thalidomide-4-O-C13-NH2 hydrochloride		Thalidomide-4-O-C13-NH2 HCl is a Thalidomide-based cereblon (E3 ligase) ligand that recruits CRBN protein.
V76435	Thalidomide-4-O-C14-NH2 hydrochloride		Thalidomide-4-O-C14-NH2 HCl is a Thalidomide-based cereblon (E3 ligase) ligand that recruits CRBN protein.
V76434	Thalidomide-4-O-C7-NH2 hydrochloride		Thalidomide-4-O-C7-NH2 HCl is a Thalidomide-based cereblon (E3 ligase) ligand that recruits CRBN proteins.
V81568	Thalidomide-4-O-C9-NH2 hydrochloride		Thalidomide-4-O-C9-NH2 HCl is a Thalidomide-based cereblon (E3 ligase) ligand that recruits CRBN protein.
V82549	Thalidomide-5-methyl	40313-92-6	Thalidomide-5-methyl is a Thalidomide-based CRBN ligand used for CRBN protein recruitment.
V82522	Thalidomide-5-NH-CH2-COO(t-Bu)	2412056-28-9	Thalidomide-5-NH-CH2-COO(t-Bu) is a t-Bu modified Thalidomide , which could be utilized as Cereblon ligand to recruit CRBN protein.