Molecular Glues

A component of molecular glues is a protein degradation agent based on the ubiquitin-proteasome pathway. Small molecule substances known as "molecular glues" have the ability to stimulate or maintain protein binding. Molecular glue can cause another protein to undergo ubiquitin modification and destruction through the proteasome pathway, which is analogous to PROTAC, if one of the proteins is an ubiquitin ligase. However, in a later classification, these compounds are categorized as functional molecules that act as E3 ligase ligands. Thalidomide, lenalidomide, and pomalidomide, as well as the later-reported CC-90009 and CC-92480, are examples of older medications that fall into this group.

Molecular Glues related products

Structure Cat No. Product Name CAS No. Product Description
V82621 2-(2,6-Dioxopiperidin-3-yl)phthalimidine-C5-Br 2411022-24-5
V1858 Cyclosporin A (Cyclosporine A) 59865-13-3 Cyclosporin A (Cyclosporine A; CsA)is anaturally occuring cyclic polypeptide immunosuppressive agent and a calcineurin inhibitor, which binds to the cyclophilin and then inhibits calcineurin with IC50 of 7 nM in a cell-free assay.
V3568 E7820 289483-69-8 E7820 (E-7820) is a novel and potent angiogenesis inhibitor and α2 integrin inhibitor with anticancer activity.
V82620 endo-BCN-PEG2-NH2 1263166-93-3
V74602 LSN3160440 2765539-59-9
V82622 Methyl-PEG4-acyl chloride 62124-69-0
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