Molecular Glues

A component of molecular glues is a protein degradation agent based on the ubiquitin-proteasome pathway. Small molecule substances known as "molecular glues" have the ability to stimulate or maintain protein binding. Molecular glue can cause another protein to undergo ubiquitin modification and destruction through the proteasome pathway, which is analogous to PROTAC, if one of the proteins is an ubiquitin ligase. However, in a later classification, these compounds are categorized as functional molecules that act as E3 ligase ligands. Thalidomide, lenalidomide, and pomalidomide, as well as the later-reported CC-90009 and CC-92480, are examples of older medications that fall into this group.

Molecular Glues related products

Cat No.	Product Name	CAS No.	Product Description
V104597	(S)-ACE-OH		(S)-ACE-OH is a molecular glue with anticancer activity.
V122267	(S,S)-PLX-4545	2892065-49-3	(S,S)-PLX-4545 is an orally effective cereblon-based molecular gel degrader that degrades IKZF2 (zinc finger transcription factor Helios).
V82621	2-(2,6-Dioxopiperidin-3-yl)phthalimidine-C5-Br	2411022-24-5	2-(2,6-Dioxopiperidin-3-yl)phthalimidine-C5-Br is a ligand (for E3 ligase)-linker conjugate used in the preparation /synthesis of PROTAC.
V128049	ABS-752	2761170-84-5	ABS-752 is a potent and orally effective GSPT1 and NEK7 molecular adhesive degrader.
V128051	ABT-002	2438239-83-7	ABT-002 is a molecular gel degrader that targets GSPT1 and NEK7.
V85957	Acetyl-cyclosporin A aldehyde	121584-52-9
V115270	BCL6-IN-10	2230406-52-5	BCL6-IN-10 (compound 6) is a selective, partially degradable molecular glue inhibitor that targets the BTB domain of BCL6, with an IC50 value of 4 nM.
V130412	BMS-986449		BMS-986449 is a highly effective and orally administered CELMoD molecular gel, and also an IKZF2/IKZF4 degrader.
V130415	BMS-986482	3062993-48-7	BMS-986482 is a CELMoD-type CRBN-mediated selective IKZF1-4 molecular gel degrader.
V130621	BRD4 degrader-7		BRD4 degrader-7 is a CTLH-dependent BRD4 degrader and c-Glue with a DC50 value of 489 nM.
V131158	CB039	3056259-55-0	CB039 is a selective molecular gel degrader that targets RBM39 (RNA-binding protein 39).
V131193	CC-647	1061605-35-3	CC-647 is a molecular gel regulator that targets Cereblon (CRBN) E3 ubiquitin ligase.
V87964	CDO1 degrader-1		CDO1 degrader-1 (compound 8) is a molecular glue degrader targeting cysteine dioxygenase (CDO1).
V105164	ChREBPα/14-3-3 regulator-1		ChREBPα/14-3-3 modulator-1 (Compound 43) is a selective molecular glue that stabilizes the interaction between carbohydrate response element binding protein (ChREBP) and 14-3-3 proteins with an EC50 of 3.8 μM.
V117231	CoREST/LSD1 degrader-1		CoREST/LSD1 degrader-1 (compound 4) is a molecular gel degrader that targets the KBTBD4 E3 ubiquitin ligase.
V105151	CQ627		CQ627 is a molecular glue that targets RIOK2 for degradation.
V132452	CRBN ligand-893		CRBN ligand-893 is a CRBN ligand with a Kd value of 0.2 μM.
V133038	Cyclosporin A-d12		Cyclosporin A-d12 is a deuterium-labeled cyclosporin A.
V118408	DD-04-038		DD-04-038 is a molecular adhesive degrader.
V133618	dGEM3		dGEM3 is a molecular glue degrader that targets GEMIN3 (a member of the motor neuron survival complex).